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- W2921041421 abstract "Critical illnesses are characterized by increased systemic cortisol availability, which is a vital part of the stress response. Relative adrenal failure (later termed critical-illness-related corticosteroid insufficiency (CIRCI)) is a condition in which the systemic availability of cortisol is assumed to be insufficiently high to face the stress of the illness and is most typically thought to occur in the acute phase of septic shock. Researchers suggested that CIRCI could be diagnosed by a suppressed incremental cortisol response to an injection of adrenocorticotropic hormone, irrespective of the baseline plasma cortisol. This concept triggered several randomized clinical trials on the impact of large stress doses of hydrocortisone to treat CIRCI, which gave conflicting results. Recent novel insights into the response of the hypothalamic-pituitary-adrenal axis to acute and prolonged critical illnesses challenge the concept of CIRCI, as currently defined, as well as the current practice guidelines for diagnosis and treatment. In this Review, these novel insights are integrated within a novel conceptual framework that can be used to re-appreciate adrenocortical function and dysfunction in the context of critical illness. This framework opens new avenues for further research and for preventive and/or therapeutic innovations." @default.
- W2921041421 created "2019-03-22" @default.
- W2921041421 creator A5010926445 @default.
- W2921041421 creator A5035530316 @default.
- W2921041421 creator A5042145557 @default.
- W2921041421 creator A5047905695 @default.
- W2921041421 date "2019-03-08" @default.
- W2921041421 modified "2023-09-29" @default.
- W2921041421 title "Adrenal function and dysfunction in critically ill patients" @default.
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