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- W2921088863 abstract "Abstract There have been significant advances in the treatment of human immunodeficiency virus-1 (HIV-1)–infected patients with hematologic malignancies due to combination antiretroviral therapy (cART), which allows treatment of immunosuppressed individuals with aggressive chemoimmunotherapy. High-dose therapy followed by autologous hematopoietic stem cell transplantation has been a standard of care for HIV-negative patients with relapsed lymphoma. Similarly, patients with leukemia are offered allogeneic stem cell transplant in an attempt to cure the disease. In the recent years, stem cell transplant has been offered to patients with HIV-1 infection in an attempt to improve their survival. Challenges in controlling HIV infection during chemotherapy-induced immunosuppression exist, and special considerations in the management of cART during induction or consolidation chemotherapy must be taken into account. Another aspect of stem cell transplantation is the use of gene therapy to confer resistance of the host stem cells to the virus. In this chapter we will review the background of HIV lymphoma, application and feasibility of stem cell transplantation, concomitant use of cART during stem cell transplant, and current advances in gene therapy for the treatment of HIV-1 infection." @default.
- W2921088863 created "2019-03-22" @default.
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- W2921088863 date "2019-01-01" @default.
- W2921088863 modified "2023-09-28" @default.
- W2921088863 title "Hematopoietic Stem Cell Transplantation for Hematologic Malignancies in HIV-Positive Patients" @default.
- W2921088863 doi "https://doi.org/10.1016/b978-0-323-56802-9.00026-2" @default.
- W2921088863 hasPublicationYear "2019" @default.
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