FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2921099347> ?p ?o ?g. }

• W2921099347 endingPage "e6553" @default.
• W2921099347 startingPage "e6553" @default.
• W2921099347 abstract "Background Previous studies reported the effect of enrofloxacin (Enro) and marbofloxacin (Mar) on cell death and alteration of the key genes involved in catabolic and anabolic processes and demonstrated the beneficial effects of hyaluronan (HA) combined with fluoroquinolones (FQs) on primary canine chondrocytes. This study further determines the effects of these treatments on canine cartilage explants in both normal and interleukin-1 beta (IL-1β)-stimulated conditions. Methods We examined sulfate glycosaminoglycan (s-GAG) release, uronic acid (UA) content, and safranin-O staining, as well as the expression patterns of inflammatory, extracellular matrix (ECM) component and enzymes. Results Enro treatment alone effectively stimulated proteoglycan anabolism by increasing UA content and glycosaminoglycans (GAGs) in normal and pre-IL-1β-stimulated explant, whereas Mar showed opposite results. The combination of HA and FQs increased s-GAG release and UA content in normal explants in addition to effective down-regulated expression of MMP3 . HA reduced the adverse effects of Mar by enhancing UA and GAG contents in both normal and pre-IL-1β-explants. Moreover, HA effectively induced HAS1 and ACAN up-regulation and reduced MMP9, TNF, PTGS2, and NFKB1 expression for a long term. Discussion Our results suggest the direct effects of Enro and Mar may selectively stimulate the conditioned explants to express MMP-codinggenes and promote gene expression involved in matrix production, pro-inflammatory cytokines, and cell degradation in different directions. HA successfully reduced the adverse effects of FQs by enhancing s-GAG and UA contents and down-regulated expression of MMPs." @default.
• W2921099347 created "2019-03-22" @default.
• W2921099347 creator A5009455195 @default.
• W2921099347 creator A5015945178 @default.
• W2921099347 creator A5021829119 @default.
• W2921099347 creator A5021952768 @default.
• W2921099347 date "2019-03-12" @default.
• W2921099347 modified "2023-09-25" @default.
• W2921099347 title "Determination of two fluoroquinolones and their combinations with hyaluronan effect in <i>in vitro</i> canine cartilage explants" @default.
• W2921099347 cites W136078608 @default.
• W2921099347 cites W1516095885 @default.
• W2921099347 cites W1533808086 @default.
• W2921099347 cites W1537174520 @default.
• W2921099347 cites W1568065429 @default.
• W2921099347 cites W1574296436 @default.
• W2921099347 cites W1840668136 @default.
• W2921099347 cites W1971496705 @default.
• W2921099347 cites W1981590270 @default.
• W2921099347 cites W1982607879 @default.
• W2921099347 cites W1986391515 @default.
• W2921099347 cites W1990635210 @default.
• W2921099347 cites W1993019119 @default.
• W2921099347 cites W1999500173 @default.
• W2921099347 cites W2004109444 @default.
• W2921099347 cites W2018943622 @default.
• W2921099347 cites W2019038382 @default.
• W2921099347 cites W2020377794 @default.
• W2921099347 cites W2022184505 @default.
• W2921099347 cites W2027251634 @default.
• W2921099347 cites W2030201897 @default.
• W2921099347 cites W2030940469 @default.
• W2921099347 cites W2037523641 @default.
• W2921099347 cites W2051728492 @default.
• W2921099347 cites W2064512855 @default.
• W2921099347 cites W2069164521 @default.
• W2921099347 cites W2070600380 @default.
• W2921099347 cites W2076936529 @default.
• W2921099347 cites W2077398406 @default.
• W2921099347 cites W2082954333 @default.
• W2921099347 cites W2099650842 @default.
• W2921099347 cites W2100664422 @default.
• W2921099347 cites W2107277218 @default.
• W2921099347 cites W2108227076 @default.
• W2921099347 cites W2110162975 @default.
• W2921099347 cites W2111687996 @default.
• W2921099347 cites W2112712660 @default.
• W2921099347 cites W2116134385 @default.
• W2921099347 cites W2116632754 @default.
• W2921099347 cites W2119567467 @default.
• W2921099347 cites W2120221257 @default.
• W2921099347 cites W2125194413 @default.
• W2921099347 cites W2143844610 @default.
• W2921099347 cites W2157637582 @default.
• W2921099347 cites W2165749967 @default.
• W2921099347 cites W2171324043 @default.
• W2921099347 cites W2187240861 @default.
• W2921099347 cites W2188931165 @default.
• W2921099347 cites W2192080449 @default.
• W2921099347 cites W2269139557 @default.
• W2921099347 cites W2270484891 @default.
• W2921099347 cites W2295515457 @default.
• W2921099347 cites W2419576956 @default.
• W2921099347 cites W2495582442 @default.
• W2921099347 cites W2593051571 @default.
• W2921099347 cites W2611234847 @default.
• W2921099347 cites W87783353 @default.
• W2921099347 cites W99462009 @default.
• W2921099347 doi "https://doi.org/10.7717/peerj.6553" @default.
• W2921099347 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6419719" @default.
• W2921099347 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30881764" @default.
• W2921099347 hasPublicationYear "2019" @default.
• W2921099347 type Work @default.
• W2921099347 sameAs 2921099347 @default.
• W2921099347 citedByCount "3" @default.
• W2921099347 countsByYear W29210993472022 @default.
• W2921099347 countsByYear W29210993472023 @default.
• W2921099347 crossrefType "journal-article" @default.
• W2921099347 hasAuthorship W2921099347A5009455195 @default.
• W2921099347 hasAuthorship W2921099347A5015945178 @default.
• W2921099347 hasAuthorship W2921099347A5021829119 @default.
• W2921099347 hasAuthorship W2921099347A5021952768 @default.
• W2921099347 hasBestOaLocation W29210993471 @default.
• W2921099347 hasConcept C1008401 @default.
• W2921099347 hasConcept C104317684 @default.
• W2921099347 hasConcept C105702510 @default.
• W2921099347 hasConcept C109523444 @default.
• W2921099347 hasConcept C127561419 @default.
• W2921099347 hasConcept C142724271 @default.
• W2921099347 hasConcept C150194340 @default.
• W2921099347 hasConcept C153074725 @default.
• W2921099347 hasConcept C153911025 @default.
• W2921099347 hasConcept C157890192 @default.
• W2921099347 hasConcept C185592680 @default.
• W2921099347 hasConcept C189165786 @default.
• W2921099347 hasConcept C197534660 @default.
• W2921099347 hasConcept C202751555 @default.
• W2921099347 hasConcept C204787440 @default.
• W2921099347 hasConcept C2776164576 @default.

• next