FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2921111094> ?p ?o ?g. }

• W2921111094 endingPage "S1302" @default.
• W2921111094 startingPage "S1301" @default.
• W2921111094 abstract "Minocycline is an oral broad-spectrum tetracycline antibiotic that is used to treat moderate to severe acne vulgaris as well as certain sexually transmitted infections. Minocycline-induced autoimmune hepatitis can be differentiated from “classic” autoimmune hepatitis by the patient's swift recovery after discontinuing the offending drug and no relapse of the condition upon discontinuation of treatment with corticosteroids. A 31-year-old Chinese woman, with past medical history of acne vulgaris, presented to the Emergency Department with nausea, vomiting, and abdominal pain for the last 3-4 days. She had experienced three episodes of non-bloody, non-bilious vomiting. She described a persistent dull aching pain in the right upper quadrant of the abdomen that had been increasing in intensity, particularly over the last two days. She denied any recent change in her diet. She reported that no one in her household had experienced similar symptoms. She denied any additional recent symptoms. Upon medication reconciliation, it was discovered that the patient had been taking minocycline, on her own and not under medical supervision, for the past three months. Initial laboratory testing was remarkable for significantly elevated transaminase levels with aspartate aminotransferase (AST) of 718 U/L (10-35 U/L) and alanine aminotransferase (ALT) of 1138 U/L (10-55 U/L). An autoimmune workup revealed an elevated antinuclear antibody (ANA) titer (1:160) (<1:40), positive anti-smooth muscle antibodies (ASMA), and the finding of hypergammaglobulinemia (3.2 g/dL) (0.7-1.6 g/dL) with elevated levels of serum immunoglobulin G (IgG) (3176 mg/dL) (700-1600 mg/dL). The bilirubin levels decreased steadily from Day 1 of the hospital admission, but the transaminase levels continued to rise despite discontinuation of the minocycline (Figure 2). On Day 7, she was started on treatment with prednisolone. Also, an IR-guided liver biopsy was performed for the purpose of confirming the diagnosis as well as to assess the degree of liver injury (Figure 3). After two days of treatment with prednisolone, the patient's transaminase levels began to decrease steadily (Figure 2). Physicians should be informed about and suspect drug-induced hepatitis for any individual taking minocycline who presents with elevated LFTs. Physicians who prescribe it to treat acne vulgaris should be aware of this potentially severe adverse effect and stop it immediately when suspicion is raised.2316_B Figure 2. Changes in total bilirubin and alanine aminotransferase (ALT) before and after treatment with prednisolone *Prednisolone, at an initial dose of 50 mg/day, was started on Day 7 of the hospital admission.2316_C Figure 3. Figure 3 (A, B, C, D; left to right). Histopathologic images of the patient's drug-induced hepatitis from liver biopsy A) Piecemeal necrosis. There is chronic inflammation in the portal tracts. H&E stain. 100x. B) Again, there is chronic inflammation in the portal tracts with many plasma cells, lymphocytes, and occasional eosinophils. H&E stain. 400x. C) and D) Spotty necrosis. There is mild chronic inflammation in the portal tracts, as well as ballooning degeneration of hepatocytes indicative of hepatocellular injury. H&E stain. 100x and 400x, respectively.2316_A Figure 1. Abdominal ultrasound There is mild hepatomegaly with increased liver echogenicity." @default.
• W2921111094 created "2019-03-22" @default.
• W2921111094 creator A5023249259 @default.
• W2921111094 creator A5063380021 @default.
• W2921111094 creator A5067477692 @default.
• W2921111094 date "2018-10-01" @default.
• W2921111094 modified "2023-09-27" @default.
• W2921111094 title "Drug-Induced Autoimmune Hepatitis in a Patient Treated With Minocycline: A Rare Adverse Effect" @default.
• W2921111094 doi "https://doi.org/10.14309/00000434-201810001-02315" @default.
• W2921111094 hasPublicationYear "2018" @default.
• W2921111094 type Work @default.
• W2921111094 sameAs 2921111094 @default.
• W2921111094 citedByCount "0" @default.
• W2921111094 crossrefType "journal-article" @default.
• W2921111094 hasAuthorship W2921111094A5023249259 @default.
• W2921111094 hasAuthorship W2921111094A5063380021 @default.
• W2921111094 hasAuthorship W2921111094A5067477692 @default.
• W2921111094 hasBestOaLocation W29211110942 @default.
• W2921111094 hasConcept C126322002 @default.
• W2921111094 hasConcept C16005928 @default.
• W2921111094 hasConcept C2776029263 @default.
• W2921111094 hasConcept C2777203481 @default.
• W2921111094 hasConcept C2777673923 @default.
• W2921111094 hasConcept C2778275353 @default.
• W2921111094 hasConcept C2778456037 @default.
• W2921111094 hasConcept C2780505380 @default.
• W2921111094 hasConcept C2780567839 @default.
• W2921111094 hasConcept C2780580376 @default.
• W2921111094 hasConcept C2780852908 @default.
• W2921111094 hasConcept C2780955771 @default.
• W2921111094 hasConcept C501593827 @default.
• W2921111094 hasConcept C71924100 @default.
• W2921111094 hasConcept C86803240 @default.
• W2921111094 hasConcept C89423630 @default.
• W2921111094 hasConcept C90924648 @default.
• W2921111094 hasConceptScore W2921111094C126322002 @default.
• W2921111094 hasConceptScore W2921111094C16005928 @default.
• W2921111094 hasConceptScore W2921111094C2776029263 @default.
• W2921111094 hasConceptScore W2921111094C2777203481 @default.
• W2921111094 hasConceptScore W2921111094C2777673923 @default.
• W2921111094 hasConceptScore W2921111094C2778275353 @default.
• W2921111094 hasConceptScore W2921111094C2778456037 @default.
• W2921111094 hasConceptScore W2921111094C2780505380 @default.
• W2921111094 hasConceptScore W2921111094C2780567839 @default.
• W2921111094 hasConceptScore W2921111094C2780580376 @default.
• W2921111094 hasConceptScore W2921111094C2780852908 @default.
• W2921111094 hasConceptScore W2921111094C2780955771 @default.
• W2921111094 hasConceptScore W2921111094C501593827 @default.
• W2921111094 hasConceptScore W2921111094C71924100 @default.
• W2921111094 hasConceptScore W2921111094C86803240 @default.
• W2921111094 hasConceptScore W2921111094C89423630 @default.
• W2921111094 hasConceptScore W2921111094C90924648 @default.
• W2921111094 hasIssue "Supplement" @default.
• W2921111094 hasLocation W29211110941 @default.
• W2921111094 hasLocation W29211110942 @default.
• W2921111094 hasOpenAccess W2921111094 @default.
• W2921111094 hasPrimaryLocation W29211110941 @default.
• W2921111094 hasRelatedWork W1994703675 @default.
• W2921111094 hasRelatedWork W2320562621 @default.
• W2921111094 hasRelatedWork W2387364079 @default.
• W2921111094 hasRelatedWork W2410017810 @default.
• W2921111094 hasRelatedWork W2410647571 @default.
• W2921111094 hasRelatedWork W2910430287 @default.
• W2921111094 hasRelatedWork W3048457546 @default.
• W2921111094 hasRelatedWork W3142684436 @default.
• W2921111094 hasRelatedWork W3143533454 @default.
• W2921111094 hasRelatedWork W4248694693 @default.
• W2921111094 hasVolume "113" @default.
• W2921111094 isParatext "false" @default.
• W2921111094 isRetracted "false" @default.
• W2921111094 magId "2921111094" @default.
• W2921111094 workType "article" @default.