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• W2921128410 abstract "Abstract Evidence has accumulated that some genes originate directly from previously non-genic sequences, or de novo , rather than by the duplication or fusion of existing genes. However, how de novo genes emerge and eventually become functional is largely unknown. Here we perform the first study on de novo genes that uses transcriptomics data from eleven different yeast species, all grown identically in both rich media and in oxidative stress conditions. The genomes of these species are densely-packed with functional elements, leaving little room for the co-option of genomic sequences into new transcribed loci. Despite this, we find that at least 213 transcripts (~5%) have arisen de novo in the past 20 million years of evolution of baker’s yeast-or approximately 10 new transcripts every million years. Nearly half of the total newly expressed sequences are generated from regions in which both DNA strands are used as templates for transcription, explaining the apparent contradiction between the limited ‘empty’ genomic space and high rate of de novo gene birth. In addition, we find that 40% of these de novo transcripts are actively translated and that at least a fraction of the encoded proteins are likely to be under purifying selection. This study shows that even in very highly compact genomes, de novo transcripts are continuously generated and can give rise to new functional protein-coding genes." @default.
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• W2921128410 date "2019-03-13" @default.
• W2921128410 modified "2023-10-15" @default.
• W2921128410 title "Frequent birth of<i>de novo</i>genes in the compact yeast genome" @default.
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• W2921128410 doi "https://doi.org/10.1101/575837" @default.
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