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• W2921134191 startingPage "7151" @default.
• W2921134191 abstract "Phase separation creates two distinct liquid phases from a single mixed liquid phase, like oil droplets separating from water. Considerable attention has focused on how the products of phase separation—the resulting condensates—might act as biological compartments, bioreactors, filters, and membraneless organelles in cells. Here, we expand this perspective, reviewing recent results showing how cells instead use the process of phase separation to sense intracellular and extracellular changes. We review case studies in phase separation-based sensing and discuss key features, such as extraordinary sensitivity, which make the process of phase separation ideally suited to meet a range of sensory challenges cells encounter. Phase separation creates two distinct liquid phases from a single mixed liquid phase, like oil droplets separating from water. Considerable attention has focused on how the products of phase separation—the resulting condensates—might act as biological compartments, bioreactors, filters, and membraneless organelles in cells. Here, we expand this perspective, reviewing recent results showing how cells instead use the process of phase separation to sense intracellular and extracellular changes. We review case studies in phase separation-based sensing and discuss key features, such as extraordinary sensitivity, which make the process of phase separation ideally suited to meet a range of sensory challenges cells encounter." @default.
• W2921134191 created "2019-03-22" @default.
• W2921134191 creator A5040351730 @default.
• W2921134191 creator A5057885534 @default.
• W2921134191 creator A5089394878 @default.
• W2921134191 date "2019-05-01" @default.
• W2921134191 modified "2023-10-16" @default.
• W2921134191 title "Cellular sensing by phase separation: Using the process, not just the products" @default.
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• W2921134191 doi "https://doi.org/10.1074/jbc.tm118.001191" @default.
• W2921134191 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6509497" @default.
• W2921134191 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30877200" @default.
• W2921134191 hasPublicationYear "2019" @default.
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