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- W2921137487 abstract "It is considered a significant challenge to construct nanocarriers that have high drug loading capacity and can overcome physiological barriers to deliver efficacious amounts of drugs to solid tumors. Here, the development of a safe, biconcave carbon nanodisk to address this challenge for treating breast cancer is reported. The nanodisk demonstrates fluorescent imaging capability, an exceedingly high loading capacity (947.8 mg g-1 , 94.78 wt%) for doxorubicin (DOX), and pH-responsive drug release. It exhibits a higher uptake rate by tumor cells and greater accumulation in tumors in a mouse model than its carbon nanosphere counterpart. In addition, the nanodisk absorbs and transforms near-infrared (NIR) light to heat, which enables simultaneous NIR-responsive drug release for chemotherapy and generation of thermal energy for tumor cell destruction. Notably, this NIR-activated dual therapy demonstrates a near complete suppression of tumor growth in a mouse model of triple-negative breast cancer when DOX-loaded nanodisks are administered systemically." @default.
- W2921137487 created "2019-03-22" @default.
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- W2921137487 date "2019-03-11" @default.
- W2921137487 modified "2023-10-16" @default.
- W2921137487 title "Biconcave Carbon Nanodisks for Enhanced Drug Accumulation and Chemo‐Photothermal Tumor Therapy" @default.
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- W2921137487 doi "https://doi.org/10.1002/adhm.201801505" @default.
- W2921137487 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6483846" @default.
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- W2921137487 hasPublicationYear "2019" @default.
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