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- W2921145794 abstract "Purpose To analyze the differences between risk factors for acute cellular (ACR) and antibody-mediated rejections (AMR) in a large cohort of highly phenotyped heart-transplant recipients. Methods We performed a multicenter, retrospective, observational study (Pitie-Salpetriere, HEGP, 2004-2016, n=1250 patients). We included all patients with at least one endomyocardial biopsy (EMB): n=1053 patients, 13677 EMB Results All patients received induction therapy (ATG = 92%). Combined transplantations were performed in 53 patients and 324 were transplanted with pre-formed DSA (31.1%). ACR were diagnosed in 458 patients (43.5%, 896 EMB) and AMR in 82 patients (7.8%, 138 EMB, figure). Risk factors for ACR included recipient's age (HR=0.990 per 1-year increment, p=0.005), type of transplantation (combined heart-kidney and heart-liver compared to isolated heart: HR = 0.243 and 0.161 respectively, p Conclusion We found 6 factors independently associated with the risk of ACR or AMR. Two factors were common between ACR and AMR (recipient's age, pre-formed DSA). These findings might help clinician to customize post-transplant follow-up." @default.
- W2921145794 created "2019-03-22" @default.
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- W2921145794 date "2019-04-01" @default.
- W2921145794 modified "2023-10-18" @default.
- W2921145794 title "Risk Factors for Cellular and Antibody-Mediated Rejections in the First-Year Post-Transplant: A Population-Based Study" @default.
- W2921145794 doi "https://doi.org/10.1016/j.healun.2019.01.983" @default.
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