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- W2921151206 abstract "LC-MS/MS has been widely used for the bioanalysis of drugs and/or metabolites in peripheral blood mononuclear cells in support of TK/TD and PK/PD assessment in drug development and therapeutic drug monitoring. However, in order to carry out a successful LC-MS/MS analysis of analyte(s) of interest in PBMCs, attentions should be made to some important details in the PBMC sample preparation workflow, including cell separation, cell counting, cell lysing and sample extraction. Depending on the study nature and physicochemical properties of the analyte(s) of interest, either Ficoll®/Histopaque® method or cell preparation tube (CPT®) method can be employed." @default.
- W2921151206 created "2019-03-22" @default.
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- W2921151206 date "2019-02-25" @default.
- W2921151206 modified "2023-09-24" @default.
- W2921151206 title "Sample Preparation for LC‐MS Bioanalysis of Peripheral Blood Mononuclear Cells" @default.
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- W2921151206 doi "https://doi.org/10.1002/9781119274315.ch17" @default.
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