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• W2921160306 abstract "Noncoding RNA (ncRNA) has a key role in regulating gene expression, mediating fundamental processes and diseases via a variety of yet unknown mechanisms. Here, we review recent applications of conventional and enhanced Molecular Dynamics (MD) simulations methods to address the mechanistic function of large biomolecular systems that are tightly involved in the ncRNA function and that are of key importance in life sciences. This compendium focuses of three biomolecular systems, namely the CRISPR-Cas9 genome editing machinery, group II intron ribozyme and the ribonucleoprotein complex of the spliceosome, which edit and process ncRNA. We show how the application of a novel accelerated MD simulations method has been key in disclosing the conformational transitions underlying RNA binding in the CRISPR-Cas9 complex, suggesting a mechanism for RNA recruitment and clarifying the conformational changes required for attaining genome editing. As well, we discuss the use of mixed quantum-classical MD simulations in deciphering the catalytic mechanism of RNA splicing as operated by group II intron ribozyme, one of the largest ncRNA structures crystallized so far. Finally, we debate the future challenges and opportunities in the field, discussing the recent application of MD simulations for unraveling the functional biophysics of the spliceosome, a multi-mega Dalton complex of proteins and small nuclear RNAs that performs RNA splicing in humans. This showcase of applications highlights the current talent of MD simulations to dissect atomic-level details of complex biomolecular systems instrumental for the design of finely engineered genome editing machines. As well, this review aims at inspiring future investigations of several other ncRNA regulatory systems, such as micro and small interfering RNAs, which achieve their function and specificity using RNA-based recognition and targeting strategies." @default.
• W2921160306 created "2019-03-22" @default.
• W2921160306 creator A5009462434 @default.
• W2921160306 creator A5025492881 @default.
• W2921160306 creator A5029026743 @default.
• W2921160306 creator A5064887398 @default.
• W2921160306 date "2019-06-01" @default.
• W2921160306 modified "2023-10-03" @default.
• W2921160306 title "Understanding the mechanistic basis of non-coding RNA through molecular dynamics simulations" @default.
• W2921160306 cites W1178456644 @default.
• W2921160306 cites W1841239836 @default.
• W2921160306 cites W1909908157 @default.
• W2921160306 cites W1970196890 @default.
• W2921160306 cites W1975734016 @default.
• W2921160306 cites W1980179156 @default.
• W2921160306 cites W1981610782 @default.
• W2921160306 cites W1988101725 @default.
• W2921160306 cites W1989383586 @default.
• W2921160306 cites W1991517789 @default.
• W2921160306 cites W1992899488 @default.
• W2921160306 cites W2003792094 @default.
• W2921160306 cites W2004303971 @default.
• W2921160306 cites W2009221497 @default.
• W2921160306 cites W2025675806 @default.
• W2921160306 cites W2027408247 @default.
• W2921160306 cites W2029582401 @default.
• W2921160306 cites W2030974598 @default.
• W2921160306 cites W2033084115 @default.
• W2921160306 cites W2035133245 @default.
• W2921160306 cites W2038354555 @default.
• W2921160306 cites W2041421251 @default.
• W2921160306 cites W2041753261 @default.
• W2921160306 cites W2045435533 @default.
• W2921160306 cites W2046001409 @default.
• W2921160306 cites W2050480410 @default.
• W2921160306 cites W2051381895 @default.
• W2921160306 cites W2052329232 @default.
• W2921160306 cites W2054642084 @default.
• W2921160306 cites W2055688390 @default.
• W2921160306 cites W2058247180 @default.
• W2921160306 cites W2063318074 @default.
• W2921160306 cites W2068205741 @default.
• W2921160306 cites W2069123478 @default.
• W2921160306 cites W2069508494 @default.
• W2921160306 cites W2069779808 @default.
• W2921160306 cites W2074018982 @default.
• W2921160306 cites W2079199763 @default.
• W2921160306 cites W2080236356 @default.
• W2921160306 cites W2081046982 @default.
• W2921160306 cites W2085716962 @default.
• W2921160306 cites W2086817352 @default.
• W2921160306 cites W2091765441 @default.
• W2921160306 cites W2093221728 @default.
• W2921160306 cites W2096261947 @default.
• W2921160306 cites W2096921126 @default.
• W2921160306 cites W2099490136 @default.
• W2921160306 cites W2107959600 @default.
• W2921160306 cites W2110058183 @default.
• W2921160306 cites W2112412611 @default.
• W2921160306 cites W2113149246 @default.
• W2921160306 cites W2113347449 @default.
• W2921160306 cites W2113568083 @default.
• W2921160306 cites W2115101918 @default.
• W2921160306 cites W2115449902 @default.
• W2921160306 cites W2122199548 @default.
• W2921160306 cites W2123182960 @default.
• W2921160306 cites W2124731003 @default.
• W2921160306 cites W2124812694 @default.
• W2921160306 cites W2131288855 @default.
• W2921160306 cites W2132589721 @default.
• W2921160306 cites W2134750225 @default.
• W2921160306 cites W2136729627 @default.
• W2921160306 cites W2142515819 @default.
• W2921160306 cites W2149655632 @default.
• W2921160306 cites W2158991904 @default.
• W2921160306 cites W2163614438 @default.
• W2921160306 cites W2164956931 @default.
• W2921160306 cites W2183569749 @default.
• W2921160306 cites W2194238612 @default.
• W2921160306 cites W2212589734 @default.
• W2921160306 cites W2237671266 @default.
• W2921160306 cites W2260248479 @default.
• W2921160306 cites W2280746094 @default.
• W2921160306 cites W2308341830 @default.
• W2921160306 cites W2313946562 @default.
• W2921160306 cites W2324524889 @default.
• W2921160306 cites W2328132257 @default.
• W2921160306 cites W2335093845 @default.
• W2921160306 cites W2335200606 @default.
• W2921160306 cites W2381608538 @default.
• W2921160306 cites W2404280981 @default.
• W2921160306 cites W2417361744 @default.
• W2921160306 cites W2417622410 @default.
• W2921160306 cites W2419308189 @default.
• W2921160306 cites W2419909218 @default.
• W2921160306 cites W2440055425 @default.
• W2921160306 cites W2463238596 @default.
• W2921160306 cites W2466528738 @default.

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