FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2921161034> ?p ?o ?g. }

• W2921161034 endingPage "845" @default.
• W2921161034 startingPage "832" @default.
• W2921161034 abstract "Modified nucleosides have been an important target for pharmaceutical development for the treatment of cancer, herpes simplex virus, and the human immunodeficiency virus (HIV). Amongst these nucleoside analogues, those based on 2′,3′-dideoxyribose sugars are quite common, particularly in anti-HIV applications. The gas-phase structures of several protonated 2′,3′-dideoxyribose nucleosides are examined in this work and compared with those of the analogous protonated DNA, RNA, and arabinose nucleosides to elucidate the influence of the 2′- and combined 2′,3′-hydroxyl groups on intrinsic structure. Infrared multiple photon dissociation (IRMPD) action spectra are collected for the protonated 2′,3′-dideoxy forms of adenosine, guanosine, cytidine, thymidine and uridine, [ddAdo+H]+, [ddGuo+H]+, [ddCyd+H]+, [ddThd+H]+, and [ddUrd+H]+, in the IR fingerprint and hydrogen-stretching regions. Molecular mechanics conformational searching followed by electronic structure calculations generates low-energy conformers of the protonated 2′,3′-dideoxynucleosides and corresponding predicted linear IR spectra to facilitate interpretation of the measured IRMPD action spectra. These experimental IRMPD spectra and theoretical calculations indicate that the absence of the 2′- and 3′-hydroxyls largely preserves the protonation preferences of the canonical forms. The spectra and calculated structures indicate a slight preference for C3′-endo sugar puckering. The presence of the 3′- and further 2′-hydroxyl increases the available intramolecular hydrogen-bonding opportunities and shifts the sugar puckering modes for all nucleosides but the guanosine analogues to a slight preference for C2′-endo over C3′-endo." @default.
• W2921161034 created "2019-03-22" @default.
• W2921161034 creator A5010936562 @default.
• W2921161034 creator A5034934143 @default.
• W2921161034 creator A5056094842 @default.
• W2921161034 creator A5068455024 @default.
• W2921161034 creator A5073748307 @default.
• W2921161034 creator A5075238840 @default.
• W2921161034 creator A5091066357 @default.
• W2921161034 date "2019-03-08" @default.
• W2921161034 modified "2023-09-27" @default.
• W2921161034 title "Impact of the 2′- and 3′-Sugar Hydroxyl Moieties on Gas-Phase Nucleoside Structure" @default.
• W2921161034 cites W1975953594 @default.
• W2921161034 cites W1979839180 @default.
• W2921161034 cites W1986270813 @default.
• W2921161034 cites W1990291419 @default.
• W2921161034 cites W1997495950 @default.
• W2921161034 cites W2015688756 @default.
• W2921161034 cites W2022211160 @default.
• W2921161034 cites W2022671360 @default.
• W2921161034 cites W2031652538 @default.
• W2921161034 cites W2038468052 @default.
• W2921161034 cites W2039020080 @default.
• W2921161034 cites W2048312581 @default.
• W2921161034 cites W2061822610 @default.
• W2921161034 cites W2072753787 @default.
• W2921161034 cites W2078145822 @default.
• W2921161034 cites W2093381148 @default.
• W2921161034 cites W2101549375 @default.
• W2921161034 cites W2106420967 @default.
• W2921161034 cites W2109801007 @default.
• W2921161034 cites W2111178780 @default.
• W2921161034 cites W2124029137 @default.
• W2921161034 cites W2124367905 @default.
• W2921161034 cites W2138473263 @default.
• W2921161034 cites W2139096485 @default.
• W2921161034 cites W2147993766 @default.
• W2921161034 cites W2159604513 @default.
• W2921161034 cites W2168003594 @default.
• W2921161034 cites W2243109121 @default.
• W2921161034 cites W2289050989 @default.
• W2921161034 cites W2297265217 @default.
• W2921161034 cites W2305295695 @default.
• W2921161034 cites W2404280981 @default.
• W2921161034 cites W2410066853 @default.
• W2921161034 cites W2888518196 @default.
• W2921161034 cites W2890168796 @default.
• W2921161034 cites W2909930949 @default.
• W2921161034 cites W2953168281 @default.
• W2921161034 cites W4214839919 @default.
• W2921161034 cites W4256083798 @default.
• W2921161034 doi "https://doi.org/10.1007/s13361-019-02155-0" @default.
• W2921161034 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30850972" @default.
• W2921161034 hasPublicationYear "2019" @default.
• W2921161034 type Work @default.
• W2921161034 sameAs 2921161034 @default.
• W2921161034 citedByCount "7" @default.
• W2921161034 countsByYear W29211610342019 @default.
• W2921161034 countsByYear W29211610342020 @default.
• W2921161034 countsByYear W29211610342021 @default.
• W2921161034 countsByYear W29211610342022 @default.
• W2921161034 countsByYear W29211610342023 @default.
• W2921161034 crossrefType "journal-article" @default.
• W2921161034 hasAuthorship W2921161034A5010936562 @default.
• W2921161034 hasAuthorship W2921161034A5034934143 @default.
• W2921161034 hasAuthorship W2921161034A5056094842 @default.
• W2921161034 hasAuthorship W2921161034A5068455024 @default.
• W2921161034 hasAuthorship W2921161034A5073748307 @default.
• W2921161034 hasAuthorship W2921161034A5075238840 @default.
• W2921161034 hasAuthorship W2921161034A5091066357 @default.
• W2921161034 hasConcept C102931765 @default.
• W2921161034 hasConcept C104317684 @default.
• W2921161034 hasConcept C112887158 @default.
• W2921161034 hasConcept C145148216 @default.
• W2921161034 hasConcept C147597530 @default.
• W2921161034 hasConcept C150487720 @default.
• W2921161034 hasConcept C178790620 @default.
• W2921161034 hasConcept C181199279 @default.
• W2921161034 hasConcept C185592680 @default.
• W2921161034 hasConcept C18705241 @default.
• W2921161034 hasConcept C2776543447 @default.
• W2921161034 hasConcept C2777995097 @default.
• W2921161034 hasConcept C2781259782 @default.
• W2921161034 hasConcept C30095370 @default.
• W2921161034 hasConcept C32909587 @default.
• W2921161034 hasConcept C3896420 @default.
• W2921161034 hasConcept C552990157 @default.
• W2921161034 hasConcept C55493867 @default.
• W2921161034 hasConcept C61234307 @default.
• W2921161034 hasConcept C67705224 @default.
• W2921161034 hasConcept C71240020 @default.
• W2921161034 hasConcept C75079739 @default.
• W2921161034 hasConcept C8010536 @default.
• W2921161034 hasConceptScore W2921161034C102931765 @default.
• W2921161034 hasConceptScore W2921161034C104317684 @default.
• W2921161034 hasConceptScore W2921161034C112887158 @default.
• W2921161034 hasConceptScore W2921161034C145148216 @default.
• W2921161034 hasConceptScore W2921161034C147597530 @default.

• next