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- W292116445 abstract "A method for producing protein-iodination-grade /sup 123/I suitable for use with a compact biomedical cyclotron is reported. The preparation of highly iodinated fibrinogen (25 /sup 123/I atoms per molecule) is described, and its successful use as a thrombus-imaging agent in experimental animals is reported. This new agent clears from the blood faster than conventional radioiodinated fibrinogen and gives higher thrombus-to-blood activity ratios. Thus, the detection of deep-vein thrombi in areas of large blood pool is enhanced, and images can be obtained sooner after administration of the radiopharmaceutical. Induced 4-8-hr-old femoral-vein thrombi in dogs can be well visualized with a scintillation camera as early as 4 hr and as late as 15 hr after administration of 1 mCi of /sup 123/I-labeled highly iodinated fibrinogen." @default.
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- W292116445 date "1976-05-01" @default.
- W292116445 modified "2023-09-23" @default.
- W292116445 title "Preparation and use of /sup 123/I-labeled highly indinated fibrinogen for imaging deep-vein thrombi. [Dogs]" @default.
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