Matches in SemOpenAlex for { <https://semopenalex.org/work/W2921182306> ?p ?o ?g. }
- W2921182306 endingPage "70" @default.
- W2921182306 startingPage "64" @default.
- W2921182306 abstract "Gastrointestinal stromal tumors (GISTs) are rare mesenchymal tumors arising in the gastrointestinal tract. Second primary tumors (SPTs) have been reported frequently, either synchronously or during follow-up, in patients diagnosed with GISTs. We carried out an electronic search of PubMed, SCOPUS, Web of Science, EMBASE, and the Cochrane Library seeking articles investigating the incidence of SPTs in patients with concomitant GIST. All studies were evaluated for heterogeneity before meta-analysis and for publication bias. Pooled incidence rate was estimated using fixed- and random-effects models. Subsite of SPTs was also investigated. A total of 32 studies met the inclusion criteria, for a total of 19,627 patients with a diagnosis of GIST. The pooled prevalence of SPTs was 20%, with 14% and 3% being synchronous and metachronous tumors, respectively. We found a risk for several specific cancer sites, in particular gastrointestinal (5%) and genitourinary tract cancers (3%). The most frequently associated malignancies were: colorectal (17%), prostate (14%), gastric (9%), esophageal (5.5%), lung (5.4%), hepato-biliopancreatic (4.7%), breast (4.6%), lymphoma (4.4%), kidney (4.35%), and sarcomas (3.3%). Regression analyses revealed a significant positive association for all SPTs with follow-up and Miettinen risk. Our results indicate that 20% of patients with GIST experienced a SPT, primarily synchronously with a diagnosis of GIST. In particular, we observed an excess of incident gastrointestinal tumors. These findings have important implications for both pathologists, who should perform extensive molecular analysis of surgical non-GIST specimens in resected patients, and for oncologists, who should continue to follow up GIST patients." @default.
- W2921182306 created "2019-03-22" @default.
- W2921182306 creator A5002724320 @default.
- W2921182306 creator A5003293741 @default.
- W2921182306 creator A5004680827 @default.
- W2921182306 creator A5008894786 @default.
- W2921182306 creator A5013554030 @default.
- W2921182306 creator A5014793005 @default.
- W2921182306 creator A5033619203 @default.
- W2921182306 creator A5044532154 @default.
- W2921182306 creator A5061179981 @default.
- W2921182306 creator A5067193136 @default.
- W2921182306 creator A5069142135 @default.
- W2921182306 creator A5071133311 @default.
- W2921182306 date "2019-06-01" @default.
- W2921182306 modified "2023-10-02" @default.
- W2921182306 title "Risk of second primary tumors in GIST survivors: A systematic review and meta-analysis" @default.
- W2921182306 cites W1204758554 @default.
- W2921182306 cites W123964025 @default.
- W2921182306 cites W1602615727 @default.
- W2921182306 cites W1824889586 @default.
- W2921182306 cites W1964435302 @default.
- W2921182306 cites W1968574529 @default.
- W2921182306 cites W1971993767 @default.
- W2921182306 cites W1979423827 @default.
- W2921182306 cites W1981491302 @default.
- W2921182306 cites W1995903531 @default.
- W2921182306 cites W2000390798 @default.
- W2921182306 cites W2010415450 @default.
- W2921182306 cites W2011324997 @default.
- W2921182306 cites W2012680945 @default.
- W2921182306 cites W2021929996 @default.
- W2921182306 cites W2022502304 @default.
- W2921182306 cites W2038741873 @default.
- W2921182306 cites W2043189323 @default.
- W2921182306 cites W2048926228 @default.
- W2921182306 cites W2051415992 @default.
- W2921182306 cites W2053372237 @default.
- W2921182306 cites W2055782534 @default.
- W2921182306 cites W2057470956 @default.
- W2921182306 cites W2058374622 @default.
- W2921182306 cites W2059242879 @default.
- W2921182306 cites W2059336038 @default.
- W2921182306 cites W2065623248 @default.
- W2921182306 cites W2077522154 @default.
- W2921182306 cites W2081011458 @default.
- W2921182306 cites W2115115592 @default.
- W2921182306 cites W2118991018 @default.
- W2921182306 cites W2121848071 @default.
- W2921182306 cites W2125435699 @default.
- W2921182306 cites W2126930838 @default.
- W2921182306 cites W2132056626 @default.
- W2921182306 cites W2133496535 @default.
- W2921182306 cites W2137150240 @default.
- W2921182306 cites W2145212405 @default.
- W2921182306 cites W2153748294 @default.
- W2921182306 cites W2157823046 @default.
- W2921182306 cites W2168083201 @default.
- W2921182306 cites W2312894731 @default.
- W2921182306 cites W2331306161 @default.
- W2921182306 cites W2344928952 @default.
- W2921182306 cites W2427828810 @default.
- W2921182306 cites W2529262765 @default.
- W2921182306 cites W2570570717 @default.
- W2921182306 cites W2606205288 @default.
- W2921182306 cites W2781525129 @default.
- W2921182306 cites W2804481851 @default.
- W2921182306 doi "https://doi.org/10.1016/j.suronc.2019.03.001" @default.
- W2921182306 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31196495" @default.
- W2921182306 hasPublicationYear "2019" @default.
- W2921182306 type Work @default.
- W2921182306 sameAs 2921182306 @default.
- W2921182306 citedByCount "9" @default.
- W2921182306 countsByYear W29211823062019 @default.
- W2921182306 countsByYear W29211823062020 @default.
- W2921182306 countsByYear W29211823062021 @default.
- W2921182306 countsByYear W29211823062022 @default.
- W2921182306 countsByYear W29211823062023 @default.
- W2921182306 crossrefType "journal-article" @default.
- W2921182306 hasAuthorship W2921182306A5002724320 @default.
- W2921182306 hasAuthorship W2921182306A5003293741 @default.
- W2921182306 hasAuthorship W2921182306A5004680827 @default.
- W2921182306 hasAuthorship W2921182306A5008894786 @default.
- W2921182306 hasAuthorship W2921182306A5013554030 @default.
- W2921182306 hasAuthorship W2921182306A5014793005 @default.
- W2921182306 hasAuthorship W2921182306A5033619203 @default.
- W2921182306 hasAuthorship W2921182306A5044532154 @default.
- W2921182306 hasAuthorship W2921182306A5061179981 @default.
- W2921182306 hasAuthorship W2921182306A5067193136 @default.
- W2921182306 hasAuthorship W2921182306A5069142135 @default.
- W2921182306 hasAuthorship W2921182306A5071133311 @default.
- W2921182306 hasConcept C120665830 @default.
- W2921182306 hasConcept C121332964 @default.
- W2921182306 hasConcept C121608353 @default.
- W2921182306 hasConcept C126322002 @default.
- W2921182306 hasConcept C133507102 @default.
- W2921182306 hasConcept C143998085 @default.
- W2921182306 hasConcept C16930146 @default.