Matches in SemOpenAlex for { <https://semopenalex.org/work/W2921186310> ?p ?o ?g. }
- W2921186310 endingPage "89" @default.
- W2921186310 startingPage "80" @default.
- W2921186310 abstract "Carboxymethyl chitosan (CMCS), a water-soluble derivative of chitosan possessing numerous enhanced physicochemical and biological properties, has emerged as a promising biopolymer carrier for new drug delivery. Norcantharidin (NCTD) is an effective anti-tumor compound with severe nephrotoxicity. In this study, norcantharidin-conjugated carboxymethyl chitosan (CMCS-NCTD) was synthesized to reduce systemic toxicity and improve anti-tumor efficiency of NCTD. Our results demonstrated that CMCS-NCTD could significantly inhibit migration of tumor cells both in vitro and in vivo in a dose-dependent manner (P < 0.05). The enhanced anti-tumor effects of CMCS-NCTD were confirmed by inhibiting the growth of solid tumors and extending survival time of tumor-bearing mice. Further investigation for the underlying mechanisms indicated that CMCS-NCTD could inhibit tumor angiogenesis and reduce degradation of extracellular matrix by regulating the expressions of VEGF, MMP-9 and TIMP-1. Overall, our findings suggested that CMCS-NCTD was an excellent polymer derivative for cancer treatment, and CMCS was a promising platform for efficient delivery of anti-cancer drugs." @default.
- W2921186310 created "2019-03-22" @default.
- W2921186310 creator A5017668306 @default.
- W2921186310 creator A5044992207 @default.
- W2921186310 creator A5059064648 @default.
- W2921186310 creator A5077626458 @default.
- W2921186310 creator A5084265319 @default.
- W2921186310 creator A5089053508 @default.
- W2921186310 date "2019-06-01" @default.
- W2921186310 modified "2023-10-16" @default.
- W2921186310 title "Synthesis and anti-metastasis activities of norcantharidin-conjugated carboxymethyl chitosan as a novel drug delivery system" @default.
- W2921186310 cites W1573363574 @default.
- W2921186310 cites W1973404232 @default.
- W2921186310 cites W1976561294 @default.
- W2921186310 cites W1979731293 @default.
- W2921186310 cites W1980629206 @default.
- W2921186310 cites W1989053944 @default.
- W2921186310 cites W1994471044 @default.
- W2921186310 cites W1995253118 @default.
- W2921186310 cites W1998796084 @default.
- W2921186310 cites W2000471330 @default.
- W2921186310 cites W2011087297 @default.
- W2921186310 cites W2021769394 @default.
- W2921186310 cites W2024028023 @default.
- W2921186310 cites W2025345565 @default.
- W2921186310 cites W2027959569 @default.
- W2921186310 cites W2028716442 @default.
- W2921186310 cites W2030042382 @default.
- W2921186310 cites W2033341544 @default.
- W2921186310 cites W2038001413 @default.
- W2921186310 cites W2043465498 @default.
- W2921186310 cites W2046944734 @default.
- W2921186310 cites W2050473255 @default.
- W2921186310 cites W2055139172 @default.
- W2921186310 cites W2057399565 @default.
- W2921186310 cites W2058568602 @default.
- W2921186310 cites W2066734110 @default.
- W2921186310 cites W2067960441 @default.
- W2921186310 cites W2073079990 @default.
- W2921186310 cites W2082803343 @default.
- W2921186310 cites W2083986465 @default.
- W2921186310 cites W2086260986 @default.
- W2921186310 cites W2087771320 @default.
- W2921186310 cites W2087835437 @default.
- W2921186310 cites W2093733034 @default.
- W2921186310 cites W2101535691 @default.
- W2921186310 cites W2115112566 @default.
- W2921186310 cites W2122855542 @default.
- W2921186310 cites W2142721942 @default.
- W2921186310 cites W2143408828 @default.
- W2921186310 cites W2146953551 @default.
- W2921186310 cites W2157233598 @default.
- W2921186310 cites W2304437938 @default.
- W2921186310 cites W2345865520 @default.
- W2921186310 cites W2434284975 @default.
- W2921186310 cites W2575815939 @default.
- W2921186310 cites W2686713560 @default.
- W2921186310 cites W2884616676 @default.
- W2921186310 cites W2915992355 @default.
- W2921186310 doi "https://doi.org/10.1016/j.carbpol.2019.03.026" @default.
- W2921186310 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30926011" @default.
- W2921186310 hasPublicationYear "2019" @default.
- W2921186310 type Work @default.
- W2921186310 sameAs 2921186310 @default.
- W2921186310 citedByCount "35" @default.
- W2921186310 countsByYear W29211863102019 @default.
- W2921186310 countsByYear W29211863102020 @default.
- W2921186310 countsByYear W29211863102021 @default.
- W2921186310 countsByYear W29211863102022 @default.
- W2921186310 countsByYear W29211863102023 @default.
- W2921186310 crossrefType "journal-article" @default.
- W2921186310 hasAuthorship W2921186310A5017668306 @default.
- W2921186310 hasAuthorship W2921186310A5044992207 @default.
- W2921186310 hasAuthorship W2921186310A5059064648 @default.
- W2921186310 hasAuthorship W2921186310A5077626458 @default.
- W2921186310 hasAuthorship W2921186310A5084265319 @default.
- W2921186310 hasAuthorship W2921186310A5089053508 @default.
- W2921186310 hasConcept C112613896 @default.
- W2921186310 hasConcept C121608353 @default.
- W2921186310 hasConcept C126322002 @default.
- W2921186310 hasConcept C150903083 @default.
- W2921186310 hasConcept C178790620 @default.
- W2921186310 hasConcept C185592680 @default.
- W2921186310 hasConcept C207001950 @default.
- W2921186310 hasConcept C2779013556 @default.
- W2921186310 hasConcept C2779732960 @default.
- W2921186310 hasConcept C2779820397 @default.
- W2921186310 hasConcept C502942594 @default.
- W2921186310 hasConcept C521977710 @default.
- W2921186310 hasConcept C55493867 @default.
- W2921186310 hasConcept C71924100 @default.
- W2921186310 hasConcept C86803240 @default.
- W2921186310 hasConcept C98274493 @default.
- W2921186310 hasConceptScore W2921186310C112613896 @default.
- W2921186310 hasConceptScore W2921186310C121608353 @default.
- W2921186310 hasConceptScore W2921186310C126322002 @default.
- W2921186310 hasConceptScore W2921186310C150903083 @default.
- W2921186310 hasConceptScore W2921186310C178790620 @default.