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- W2921226781 abstract "Purpose Increased burden of lung bacteria is common in chronic lung diseases, is correlated with decreased lung function, and predicts disease progression. Bacterial burden is increased following lung transplant, but the relationship between bacterial burden and allograft dysfunction is unknown. Methods We obtained 294 bronchoalveolar lavage (BAL) fluid specimens from 214 unique lung transplant recipients. We quantified lung bacterial burden as number of 16S rRNA copies per mL of BAL fluid using droplet digital PCR (Bio-Rad), a novel, ultrasensitive platform. The onset of chronic lung allograft dysfunction (CLAD) was determined using the standard definition of the first of two consecutive FEV1 measurements ≤80% post-transplant baseline. Bacterial burden was compared using the Wilcoxon rank-sum test and percentages were compared using the Chi-square test. Results We compared 145 (49%) BAL specimens collected while patients were CLAD-free (largely for routine surveillance) with 149 (51%) BAL specimens collected after developing CLAD. Bacterial culture results did not differ between the two groups, with 19 (13%) CLAD free samples having positive cultures and 33 (22%) samples positive cultures after the onset of CLAD (p=0.07). However, using culture-independent methods, we found a higher bacterial burden in BAL samples collected after developing CLAD than in the CLAD free samples (p Conclusion Lung bacterial burden is increased following the onset of CLAD. Further investigation will determine the pathogenic and clinical significance of airway dysbiosis in the progression of lung allograft dysfunction." @default.
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- W2921226781 date "2019-04-01" @default.
- W2921226781 modified "2023-09-27" @default.
- W2921226781 title "Lung Bacterial Burden is Increased Following the Onset of Chronic Rejection" @default.
- W2921226781 doi "https://doi.org/10.1016/j.healun.2019.01.395" @default.
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