FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2921254305> ?p ?o ?g. }

• W2921254305 endingPage "9" @default.
• W2921254305 startingPage "1" @default.
• W2921254305 abstract "Previous studies have linked systemic glucocorticoid use with intestinal perforation. However, the association between intestinal perforation and endogenous hypercortisolism has not been well described, with only 14 previously published case reports. In this study, we investigated if intestinal perforation occurred more frequently in patients with ectopic ACTH syndrome and in those with a greater than 10-fold elevation of 24-hour urinary free cortisol level. Of 110 patients with ACTH-dependent Cushing's syndrome followed in two clinics in Canada, six cases with intestinal perforation were identified over 15 years. Age of patients ranged from 52 to 72, five females and one male, four with Cushing's disease and two with ectopic ACTH production, one from a pancreatic neuroendocrine tumor and one from medullary carcinoma of the thyroid. Five had diverticular perforation and one had intestinal perforation from a stercoral ulcer. All cases had their lower intestinal perforation when the cortisol production was high, and one patient had diverticular perforation 15 months prior to the diagnosis of Cushing's disease. As in previously reported cases, most had hypokalemia and abdominal pain with minimal or no peritoneal symptoms and this occurred during the active phase of Cushing's syndrome. Whereas all previously reported cases occurred in patients with 24-hour urinary free cortisol levels greater than 10-fold the upper limit of normal when measured and 11 of 14 patients had ectopic ACTH production, only one of our patients had this degree of hypercortisolism and four of our six patients had Cushing's disease. Similar to exogenous steroid use, patients with endogenous hypercortisolism also have a higher risk of intestinal, in particular diverticular, perforation and should be monitored closely for its occurrence with a low threshold for investigation and surgical intervention. Elective colonoscopy probably should be deferred until Cushing's syndrome is under control." @default.
• W2921254305 created "2019-03-22" @default.
• W2921254305 creator A5066447916 @default.
• W2921254305 creator A5079111919 @default.
• W2921254305 creator A5091301621 @default.
• W2921254305 date "2019-03-13" @default.
• W2921254305 modified "2023-10-05" @default.
• W2921254305 title "Intestinal Perforation in ACTH-Dependent Cushing’s Syndrome" @default.
• W2921254305 cites W1979799880 @default.
• W2921254305 cites W1980265495 @default.
• W2921254305 cites W2004639734 @default.
• W2921254305 cites W2005673043 @default.
• W2921254305 cites W2005687434 @default.
• W2921254305 cites W2022653289 @default.
• W2921254305 cites W2022982570 @default.
• W2921254305 cites W2039715044 @default.
• W2921254305 cites W2043905723 @default.
• W2921254305 cites W2044419553 @default.
• W2921254305 cites W2044520594 @default.
• W2921254305 cites W2057971651 @default.
• W2921254305 cites W2075033752 @default.
• W2921254305 cites W2075603824 @default.
• W2921254305 cites W2086235189 @default.
• W2921254305 cites W2089069649 @default.
• W2921254305 cites W2102260471 @default.
• W2921254305 cites W2112273056 @default.
• W2921254305 cites W2134467188 @default.
• W2921254305 cites W2150511492 @default.
• W2921254305 cites W2159931632 @default.
• W2921254305 cites W2162196280 @default.
• W2921254305 cites W2247300620 @default.
• W2921254305 cites W2252480204 @default.
• W2921254305 cites W2341273227 @default.
• W2921254305 cites W2398771245 @default.
• W2921254305 cites W2428792514 @default.
• W2921254305 cites W2518204345 @default.
• W2921254305 cites W2806808150 @default.
• W2921254305 doi "https://doi.org/10.1155/2019/9721781" @default.
• W2921254305 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6436364" @default.
• W2921254305 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31001560" @default.
• W2921254305 hasPublicationYear "2019" @default.
• W2921254305 type Work @default.
• W2921254305 sameAs 2921254305 @default.
• W2921254305 citedByCount "5" @default.
• W2921254305 countsByYear W29212543052021 @default.
• W2921254305 countsByYear W29212543052022 @default.
• W2921254305 countsByYear W29212543052023 @default.
• W2921254305 crossrefType "journal-article" @default.
• W2921254305 hasAuthorship W2921254305A5066447916 @default.
• W2921254305 hasAuthorship W2921254305A5079111919 @default.
• W2921254305 hasAuthorship W2921254305A5091301621 @default.
• W2921254305 hasBestOaLocation W29212543051 @default.
• W2921254305 hasConcept C126322002 @default.
• W2921254305 hasConcept C134018914 @default.
• W2921254305 hasConcept C141071460 @default.
• W2921254305 hasConcept C191897082 @default.
• W2921254305 hasConcept C192562407 @default.
• W2921254305 hasConcept C2778242168 @default.
• W2921254305 hasConcept C2778456384 @default.
• W2921254305 hasConcept C2778527123 @default.
• W2921254305 hasConcept C71924100 @default.
• W2921254305 hasConcept C90924648 @default.
• W2921254305 hasConceptScore W2921254305C126322002 @default.
• W2921254305 hasConceptScore W2921254305C134018914 @default.
• W2921254305 hasConceptScore W2921254305C141071460 @default.
• W2921254305 hasConceptScore W2921254305C191897082 @default.
• W2921254305 hasConceptScore W2921254305C192562407 @default.
• W2921254305 hasConceptScore W2921254305C2778242168 @default.
• W2921254305 hasConceptScore W2921254305C2778456384 @default.
• W2921254305 hasConceptScore W2921254305C2778527123 @default.
• W2921254305 hasConceptScore W2921254305C71924100 @default.
• W2921254305 hasConceptScore W2921254305C90924648 @default.
• W2921254305 hasLocation W29212543051 @default.
• W2921254305 hasLocation W29212543052 @default.
• W2921254305 hasLocation W29212543053 @default.
• W2921254305 hasLocation W29212543054 @default.
• W2921254305 hasOpenAccess W2921254305 @default.
• W2921254305 hasPrimaryLocation W29212543051 @default.
• W2921254305 hasRelatedWork W1966504330 @default.
• W2921254305 hasRelatedWork W1979139803 @default.
• W2921254305 hasRelatedWork W2030889776 @default.
• W2921254305 hasRelatedWork W2037631372 @default.
• W2921254305 hasRelatedWork W2040058909 @default.
• W2921254305 hasRelatedWork W2132898409 @default.
• W2921254305 hasRelatedWork W2376769477 @default.
• W2921254305 hasRelatedWork W2748952813 @default.
• W2921254305 hasRelatedWork W4249176446 @default.
• W2921254305 hasRelatedWork W2041694770 @default.
• W2921254305 hasVolume "2019" @default.
• W2921254305 isParatext "false" @default.
• W2921254305 isRetracted "false" @default.
• W2921254305 magId "2921254305" @default.
• W2921254305 workType "article" @default.