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- W2921281224 abstract "Sparse profiling of CpG methylation in blood by microarrays has identified epigenetic links to common diseases. Here we apply methylC-capture sequencing (MCC-Seq) in a clinical population of ~200 adipose tissue and matched blood samples (Ntotal~400), providing high-resolution methylation profiling (>1.3 M CpGs) at regulatory elements. We link methylation to cardiometabolic risk through associations to circulating plasma lipid levels and identify lipid-associated CpGs with unique localization patterns in regulatory elements. We show distinct features of tissue-specific versus tissue-independent lipid-linked regulatory regions by contrasting with parallel assessments in ~800 independent adipose tissue and blood samples from the general population. We follow-up on adipose-specific regulatory regions under (1) genetic and (2) epigenetic (environmental) regulation via integrational studies. Overall, the comprehensive sequencing of regulatory element methylomes reveals a rich landscape of functional variants linked genetically as well as epigenetically to plasma lipid traits." @default.
- W2921281224 created "2019-03-22" @default.
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- W2921281224 date "2019-03-14" @default.
- W2921281224 modified "2023-09-30" @default.
- W2921281224 title "Dissecting features of epigenetic variants underlying cardiometabolic risk using full-resolution epigenome profiling in regulatory elements" @default.
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- W2921281224 doi "https://doi.org/10.1038/s41467-019-09184-z" @default.
- W2921281224 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6418220" @default.
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