FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2921296780> ?p ?o ?g. }

• W2921296780 endingPage "12858" @default.
• W2921296780 startingPage "12843" @default.
• W2921296780 abstract "Abstract Hemostasis is a tightly regulated process which maintains a fluid state of blood within the vasculature and provides thrombotic response upon tissue injury. Various scientific studies have implicated the role of plant latex proteases in hemostasis using in vitro experiments. However, in vivo models substantiate their role in hemostasis. Therefore, in the present study, the effect of plant latex thrombin‐like proteases (PTLPs) on hemostasis was investigated systematically using mice tail bleeding as a preclinical model. In this direction, latex protease fractions (LPFs), which showed potent thrombin‐like activity, were selected as they act directly on fibrinogen to form clot and quickly stop bleeding. Thrombin‐like activity was exhibited mainly by cysteine proteases. Calotropis gigantea , Carica papaya, Jatropha curcas, Oxystelma esculentum , Tabernaemontana divaricata , and Vallaris solanacea LPFs and papain from C . papaya latex significantly reduced bleeding on a topical application in normal and aspirin administered mice. In addition, PTLPs accelerated the clotting of factor VIII deficient plasma, while, papain brought back the clotting time to normal levels acting like a bypassing agent. Further, papain failed to show activity in the presence of specific cysteine protease inhibitor iodoacetic acid; confirming protease role in all the activities exhibited. At the tested dose, PTLPs except C . gigantea did not show toxicity. Further, structural and sequence comparison between PTLPs and human thrombin revealed structural and sequence dissimilarity indicating their unique nature. The findings of the present study may open up a new avenue for considering PTLPs including papain in the treatment of bleeding wounds." @default.
• W2921296780 created "2019-03-22" @default.
• W2921296780 creator A5000500649 @default.
• W2921296780 creator A5009522207 @default.
• W2921296780 creator A5010700814 @default.
• W2921296780 creator A5010824031 @default.
• W2921296780 creator A5011003294 @default.
• W2921296780 creator A5019875833 @default.
• W2921296780 creator A5029602819 @default.
• W2921296780 creator A5029817611 @default.
• W2921296780 creator A5029828893 @default.
• W2921296780 creator A5031593614 @default.
• W2921296780 creator A5082223664 @default.
• W2921296780 creator A5089450381 @default.
• W2921296780 date "2019-03-12" @default.
• W2921296780 modified "2023-10-12" @default.
• W2921296780 title "Plant latex thrombin‐like cysteine proteases alleviates bleeding by bypassing factor VIII in murine model" @default.
• W2921296780 cites W1826459868 @default.
• W2921296780 cites W1967912613 @default.
• W2921296780 cites W1969965303 @default.
• W2921296780 cites W1970420129 @default.
• W2921296780 cites W1980537409 @default.
• W2921296780 cites W1984064585 @default.
• W2921296780 cites W1990097426 @default.
• W2921296780 cites W1991247700 @default.
• W2921296780 cites W2008708467 @default.
• W2921296780 cites W2011868289 @default.
• W2921296780 cites W2015509707 @default.
• W2921296780 cites W2019716166 @default.
• W2921296780 cites W2019978657 @default.
• W2921296780 cites W2021288331 @default.
• W2921296780 cites W2023042965 @default.
• W2921296780 cites W2028409854 @default.
• W2921296780 cites W2028724011 @default.
• W2921296780 cites W2029325447 @default.
• W2921296780 cites W2031078729 @default.
• W2921296780 cites W2040554454 @default.
• W2921296780 cites W2040981235 @default.
• W2921296780 cites W2044360758 @default.
• W2921296780 cites W2046645837 @default.
• W2921296780 cites W2047707618 @default.
• W2921296780 cites W2052731599 @default.
• W2921296780 cites W2055946612 @default.
• W2921296780 cites W2056994199 @default.
• W2921296780 cites W2059994793 @default.
• W2921296780 cites W2072668273 @default.
• W2921296780 cites W2075503331 @default.
• W2921296780 cites W2079722201 @default.
• W2921296780 cites W2079831464 @default.
• W2921296780 cites W2092326985 @default.
• W2921296780 cites W2105662874 @default.
• W2921296780 cites W2122879678 @default.
• W2921296780 cites W2127322768 @default.
• W2921296780 cites W2130479394 @default.
• W2921296780 cites W2132629607 @default.
• W2921296780 cites W2147000186 @default.
• W2921296780 cites W2147342914 @default.
• W2921296780 cites W2216872050 @default.
• W2921296780 cites W2400185552 @default.
• W2921296780 cites W2406996360 @default.
• W2921296780 cites W2469828364 @default.
• W2921296780 cites W2521288222 @default.
• W2921296780 cites W2739999456 @default.
• W2921296780 cites W2765720259 @default.
• W2921296780 cites W2799911900 @default.
• W2921296780 cites W4205480613 @default.
• W2921296780 cites W4293247451 @default.
• W2921296780 cites W1004622453 @default.
• W2921296780 cites W2754747644 @default.
• W2921296780 doi "https://doi.org/10.1002/jcb.28555" @default.
• W2921296780 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30861186" @default.
• W2921296780 hasPublicationYear "2019" @default.
• W2921296780 type Work @default.
• W2921296780 sameAs 2921296780 @default.
• W2921296780 citedByCount "11" @default.
• W2921296780 countsByYear W29212967802020 @default.
• W2921296780 countsByYear W29212967802021 @default.
• W2921296780 countsByYear W29212967802022 @default.
• W2921296780 countsByYear W29212967802023 @default.
• W2921296780 crossrefType "journal-article" @default.
• W2921296780 hasAuthorship W2921296780A5000500649 @default.
• W2921296780 hasAuthorship W2921296780A5009522207 @default.
• W2921296780 hasAuthorship W2921296780A5010700814 @default.
• W2921296780 hasAuthorship W2921296780A5010824031 @default.
• W2921296780 hasAuthorship W2921296780A5011003294 @default.
• W2921296780 hasAuthorship W2921296780A5019875833 @default.
• W2921296780 hasAuthorship W2921296780A5029602819 @default.
• W2921296780 hasAuthorship W2921296780A5029817611 @default.
• W2921296780 hasAuthorship W2921296780A5029828893 @default.
• W2921296780 hasAuthorship W2921296780A5031593614 @default.
• W2921296780 hasAuthorship W2921296780A5082223664 @default.
• W2921296780 hasAuthorship W2921296780A5089450381 @default.
• W2921296780 hasConcept C112516734 @default.
• W2921296780 hasConcept C126322002 @default.
• W2921296780 hasConcept C181199279 @default.
• W2921296780 hasConcept C182220744 @default.
• W2921296780 hasConcept C185592680 @default.
• W2921296780 hasConcept C203014093 @default.

• next