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- W2921336638 abstract "The crucial role of androgen receptor (AR) in prostate cancer development is well documented, and its inhibition is a mainstay of prostate cancer treatment. Here, we analyze the perturbations to the AR cistrome caused by a minor groove binding molecule that is designed to target a sequence found in a subset of androgen response elements (ARE). We find treatment with this pyrrole-imidazole (Py-Im) polyamide exhibits sequence selectivity in its repression of AR binding in vivo. Differentially changed loci are enriched for sequences resembling ARE half-sites that match the Py-Im polyamide binding preferences determined in vitro. Comparatively, permutations of the ARE half-site bearing single or double mismatches to the Py-Im polyamide binding sequence are not enriched. This study confirms that the in vivo perturbation pattern caused by a sequence specific polyamide correlates with its in vitro binding preference genome-wide in an unbiased manner." @default.
- W2921336638 created "2019-03-22" @default.
- W2921336638 creator A5023919307 @default.
- W2921336638 creator A5076578241 @default.
- W2921336638 date "2019-03-06" @default.
- W2921336638 modified "2023-10-13" @default.
- W2921336638 title "Sequence specific suppression of androgen receptor–DNA binding in vivo by a Py-Im polyamide" @default.
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- W2921336638 doi "https://doi.org/10.1093/nar/gkz153" @default.
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