Matches in SemOpenAlex for { <https://semopenalex.org/work/W2921338391> ?p ?o ?g. }
Showing items 1 to 80 of
80
with 100 items per page.
- W2921338391 abstract "Monocytes exhibiting a pro-inflammatory phenotype play a key role in adhesion and development of atherosclerotic plaques. Next generation tobacco and nicotine products (NGPs) are now widely used globally as an alternative to smoking. Little is known about their pro-inflammatory effects on monocytes. We investigated cell viability, anti-oxidant and pro-inflammatory gene and protein expression in THP-1 monocytes exposed to aqueous extracts of conventional cigarettes (CSE), a tobacco heating product (THP) and an electronic cigarette (EC). Pure nicotine was used as additional control. Treatment with CSE reduced cell viability in a dose-dependent manner, whereas all other test agents showed no difference to control. At the highest non-lethal dose of CSE (20%) the following notable mRNA expression changes were observed for CSE, THP and EC respectively, relative to control; HMOX1 (6-fold, <2-fold, <2-fold), NQO1 (3.5-fold, <2-fold, <2-fold), CCL2 (4-fold, 3.5-fold, 2.5-fold), IL1B (4-fold, 3-fold, <2-fold), IL8 (5-fold, 2-fold, 2-fold), TNF (2-fold, 2-fold, <2-fold), CD31 and ICAM1 were below the 2-fold threshold for all products. With respect to protein expression; IL1B (3-fold, <2-fold, <2-fold) and IL8 (3.5-fold, 2-fold, 2-fold) were elevated over the 2-fold threshold, whereas, CD31, ICAM1, TNF and CCL2 were below 2-fold expression for all products. At higher doses, greater inductions were observed with all extracts; however NGP responses were typically lower than CSE. In conclusion, anti-oxidative and pro-inflammatory processes were activated by all products. NGPs showed similar or lower responses relative to controls than CSE exposed cells." @default.
- W2921338391 created "2019-03-22" @default.
- W2921338391 creator A5020154802 @default.
- W2921338391 creator A5027171173 @default.
- W2921338391 creator A5034627046 @default.
- W2921338391 creator A5040932572 @default.
- W2921338391 creator A5043234609 @default.
- W2921338391 creator A5067554955 @default.
- W2921338391 creator A5081891613 @default.
- W2921338391 date "2018-05-01" @default.
- W2921338391 modified "2023-09-23" @default.
- W2921338391 title "Abstract 241: Impact of Cigarette Smoke, Next Generation Tobacco and Nicotine Products on the Cytotoxic, Oxidative and Pro-Inflammatory Status of THP-1 Cells" @default.
- W2921338391 doi "https://doi.org/10.1161/atvb.38.suppl_1.241" @default.
- W2921338391 hasPublicationYear "2018" @default.
- W2921338391 type Work @default.
- W2921338391 sameAs 2921338391 @default.
- W2921338391 citedByCount "0" @default.
- W2921338391 crossrefType "journal-article" @default.
- W2921338391 hasAuthorship W2921338391A5020154802 @default.
- W2921338391 hasAuthorship W2921338391A5027171173 @default.
- W2921338391 hasAuthorship W2921338391A5034627046 @default.
- W2921338391 hasAuthorship W2921338391A5040932572 @default.
- W2921338391 hasAuthorship W2921338391A5043234609 @default.
- W2921338391 hasAuthorship W2921338391A5067554955 @default.
- W2921338391 hasAuthorship W2921338391A5081891613 @default.
- W2921338391 hasConcept C101666144 @default.
- W2921338391 hasConcept C126322002 @default.
- W2921338391 hasConcept C127413603 @default.
- W2921338391 hasConcept C13373296 @default.
- W2921338391 hasConcept C1491633281 @default.
- W2921338391 hasConcept C153911025 @default.
- W2921338391 hasConcept C170493617 @default.
- W2921338391 hasConcept C185592680 @default.
- W2921338391 hasConcept C203014093 @default.
- W2921338391 hasConcept C2779547902 @default.
- W2921338391 hasConcept C2781184567 @default.
- W2921338391 hasConcept C53227056 @default.
- W2921338391 hasConcept C53942344 @default.
- W2921338391 hasConcept C55493867 @default.
- W2921338391 hasConcept C71924100 @default.
- W2921338391 hasConcept C78519656 @default.
- W2921338391 hasConcept C86803240 @default.
- W2921338391 hasConcept C98274493 @default.
- W2921338391 hasConceptScore W2921338391C101666144 @default.
- W2921338391 hasConceptScore W2921338391C126322002 @default.
- W2921338391 hasConceptScore W2921338391C127413603 @default.
- W2921338391 hasConceptScore W2921338391C13373296 @default.
- W2921338391 hasConceptScore W2921338391C1491633281 @default.
- W2921338391 hasConceptScore W2921338391C153911025 @default.
- W2921338391 hasConceptScore W2921338391C170493617 @default.
- W2921338391 hasConceptScore W2921338391C185592680 @default.
- W2921338391 hasConceptScore W2921338391C203014093 @default.
- W2921338391 hasConceptScore W2921338391C2779547902 @default.
- W2921338391 hasConceptScore W2921338391C2781184567 @default.
- W2921338391 hasConceptScore W2921338391C53227056 @default.
- W2921338391 hasConceptScore W2921338391C53942344 @default.
- W2921338391 hasConceptScore W2921338391C55493867 @default.
- W2921338391 hasConceptScore W2921338391C71924100 @default.
- W2921338391 hasConceptScore W2921338391C78519656 @default.
- W2921338391 hasConceptScore W2921338391C86803240 @default.
- W2921338391 hasConceptScore W2921338391C98274493 @default.
- W2921338391 hasIssue "Suppl_1" @default.
- W2921338391 hasLocation W29213383911 @default.
- W2921338391 hasOpenAccess W2921338391 @default.
- W2921338391 hasPrimaryLocation W29213383911 @default.
- W2921338391 hasRelatedWork W1494939326 @default.
- W2921338391 hasRelatedWork W1970486150 @default.
- W2921338391 hasRelatedWork W1996687338 @default.
- W2921338391 hasRelatedWork W2024599954 @default.
- W2921338391 hasRelatedWork W2029205859 @default.
- W2921338391 hasRelatedWork W2057983183 @default.
- W2921338391 hasRelatedWork W2092742666 @default.
- W2921338391 hasRelatedWork W2105068995 @default.
- W2921338391 hasRelatedWork W2133617154 @default.
- W2921338391 hasRelatedWork W2323174039 @default.
- W2921338391 hasVolume "38" @default.
- W2921338391 isParatext "false" @default.
- W2921338391 isRetracted "false" @default.
- W2921338391 magId "2921338391" @default.
- W2921338391 workType "article" @default.