Matches in SemOpenAlex for { <https://semopenalex.org/work/W2921342657> ?p ?o ?g. }
- W2921342657 abstract "Antimicrobial resistance (AMR) is a serious threat to global public health, but obtaining representative data on AMR for healthy human populations is difficult. Here, we use metagenomic analysis of untreated sewage to characterize the bacterial resistome from 79 sites in 60 countries. We find systematic differences in abundance and diversity of AMR genes between Europe/North-America/Oceania and Africa/Asia/South-America. Antimicrobial use data and bacterial taxonomy only explains a minor part of the AMR variation that we observe. We find no evidence for cross-selection between antimicrobial classes, or for effect of air travel between sites. However, AMR gene abundance strongly correlates with socio-economic, health and environmental factors, which we use to predict AMR gene abundances in all countries in the world. Our findings suggest that global AMR gene diversity and abundance vary by region, and that improving sanitation and health could potentially limit the global burden of AMR. We propose metagenomic analysis of sewage as an ethically acceptable and economically feasible approach for continuous global surveillance and prediction of AMR." @default.
- W2921342657 created "2019-03-22" @default.
- W2921342657 creator A5001809968 @default.
- W2921342657 creator A5003174157 @default.
- W2921342657 creator A5004393393 @default.
- W2921342657 creator A5007991033 @default.
- W2921342657 creator A5008677339 @default.
- W2921342657 creator A5017761814 @default.
- W2921342657 creator A5021392982 @default.
- W2921342657 creator A5021776590 @default.
- W2921342657 creator A5024233200 @default.
- W2921342657 creator A5024307534 @default.
- W2921342657 creator A5027103374 @default.
- W2921342657 creator A5028263371 @default.
- W2921342657 creator A5034041854 @default.
- W2921342657 creator A5038551060 @default.
- W2921342657 creator A5039266783 @default.
- W2921342657 creator A5043156226 @default.
- W2921342657 creator A5052627096 @default.
- W2921342657 creator A5052717801 @default.
- W2921342657 creator A5053723681 @default.
- W2921342657 creator A5054858869 @default.
- W2921342657 creator A5058102881 @default.
- W2921342657 creator A5059832116 @default.
- W2921342657 creator A5060493208 @default.
- W2921342657 creator A5062072218 @default.
- W2921342657 creator A5062145328 @default.
- W2921342657 creator A5062827789 @default.
- W2921342657 creator A5064536413 @default.
- W2921342657 creator A5069744000 @default.
- W2921342657 creator A5071462078 @default.
- W2921342657 creator A5072348463 @default.
- W2921342657 creator A5072477553 @default.
- W2921342657 creator A5083485471 @default.
- W2921342657 creator A5090832160 @default.
- W2921342657 date "2019-03-08" @default.
- W2921342657 modified "2023-10-14" @default.
- W2921342657 title "Global monitoring of antimicrobial resistance based on metagenomics analyses of urban sewage" @default.
- W2921342657 cites W1507255258 @default.
- W2921342657 cites W1748215068 @default.
- W2921342657 cites W1954661791 @default.
- W2921342657 cites W1977678315 @default.
- W2921342657 cites W1979724564 @default.
- W2921342657 cites W2006011291 @default.
- W2921342657 cites W2022769108 @default.
- W2921342657 cites W2037900484 @default.
- W2921342657 cites W2051087256 @default.
- W2921342657 cites W2053989303 @default.
- W2921342657 cites W2064186732 @default.
- W2921342657 cites W2067136681 @default.
- W2921342657 cites W2067885219 @default.
- W2921342657 cites W2097981845 @default.
- W2921342657 cites W2108234281 @default.
- W2921342657 cites W2108638835 @default.
- W2921342657 cites W2109936878 @default.
- W2921342657 cites W2115478866 @default.
- W2921342657 cites W2122043888 @default.
- W2921342657 cites W2123186607 @default.
- W2921342657 cites W2134852597 @default.
- W2921342657 cites W2142169580 @default.
- W2921342657 cites W2158669671 @default.
- W2921342657 cites W2163861300 @default.
- W2921342657 cites W2207760002 @default.
- W2921342657 cites W2244486986 @default.
- W2921342657 cites W2313711895 @default.
- W2921342657 cites W2380447136 @default.
- W2921342657 cites W2414773406 @default.
- W2921342657 cites W2520500449 @default.
- W2921342657 cites W2552637961 @default.
- W2921342657 cites W2593086047 @default.
- W2921342657 cites W2610952444 @default.
- W2921342657 cites W2736364303 @default.
- W2921342657 cites W2763276883 @default.
- W2921342657 cites W2765719039 @default.
- W2921342657 cites W2791781902 @default.
- W2921342657 cites W2805164387 @default.
- W2921342657 cites W2911964244 @default.
- W2921342657 cites W2950150251 @default.
- W2921342657 cites W2951947140 @default.
- W2921342657 cites W3123649847 @default.
- W2921342657 cites W4232478844 @default.
- W2921342657 doi "https://doi.org/10.1038/s41467-019-08853-3" @default.
- W2921342657 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6408512" @default.
- W2921342657 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30850636" @default.
- W2921342657 hasPublicationYear "2019" @default.
- W2921342657 type Work @default.
- W2921342657 sameAs 2921342657 @default.
- W2921342657 citedByCount "540" @default.
- W2921342657 countsByYear W29213426572019 @default.
- W2921342657 countsByYear W29213426572020 @default.
- W2921342657 countsByYear W29213426572021 @default.
- W2921342657 countsByYear W29213426572022 @default.
- W2921342657 countsByYear W29213426572023 @default.
- W2921342657 crossrefType "journal-article" @default.
- W2921342657 hasAuthorship W2921342657A5001809968 @default.
- W2921342657 hasAuthorship W2921342657A5003174157 @default.
- W2921342657 hasAuthorship W2921342657A5004393393 @default.
- W2921342657 hasAuthorship W2921342657A5007991033 @default.
- W2921342657 hasAuthorship W2921342657A5008677339 @default.
- W2921342657 hasAuthorship W2921342657A5017761814 @default.