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- W2921350802 abstract "Introduction: Acute pancreatitis (AP) is a frequent cause of hospitalization. Cannabis is the most frequently used illicit drug in the world. There is increasing inconclusive evidence about the impact of cannabis in AP. The aim of this study was to identify the prevalence of cannabis use among all patients with AP in the US and investigate the impact of cannabis use on mortality, morbidity, and cost. Methods: The National Inpatient Sample (NIS) database from 2003 to 2013 was queried for all patients with a discharge diagnosis of AP (ICD-9 577.0). Active exposure to cannabis was ascertained based on ICD-9 305.2. Outcomes included in-hospital mortality, length of stay (LOS), inflation adjusted charges, acute kidney failure, ARDS, and shock. Results were adjusted for age, gender, race, Charlson comorbidity index (CCI), median income quartile, and hospital characteristics. Multivariable logistic regression models were constructed using SAS software (version 9.4, The SAS Institute, Cary, NC). Results: Over 2.8 million patients with AP patients were analyzed [Table 1]. Cannabis use prevalence was 0.3%. Patients exposed to cannabis were younger and mostly males. After adjusting for these factors, the cannabis group had significantly lower inpatient mortality compared to the non-cannabis group (OR 0.17, CI: 0.06-0.53). Cannabis-users also had decreased LOS (4.1 vs. 5.2 days), inflation-adjusted charges ($21,398 vs. $27,488), acute kidney failure (OR: 0.82), ileus (OR: 0.71), shock (OR: 0.39), ARDS (OR: 0.40), and need for parenteral nutrition (OR: 0.66) (95% CI, table 2). Conclusion: Limitations: Inpatient data only (missing post discharge outcomes lacking), potential for misclassification (many cannabis users may not have the ICD9 code). Strength: Largest patient cohort to date. Adjusted for age, gender, race, and Charlson comorbidity index (CCI), median income quartile, and hospital characteristics. Conclusion: In AP, cannabis users had lower age-adjusted mortality, morbidity and hospitalization-cost. The interplay of these factors remains unknown and further clinical and molecular studies on how cannabis affects the pancreas during AP are needed.10_A Figure 1. Patient Characteristics10_B Figure 2. Association Between Cannabis and Binary Outcomes of AP10_C Figure 3. Trends in charges" @default.
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- W2921350802 date "2018-10-01" @default.
- W2921350802 modified "2023-09-27" @default.
- W2921350802 title "Is There an Impact of Cannabis Consumption on Acute Pancreatitis in the United States?" @default.
- W2921350802 doi "https://doi.org/10.14309/00000434-201810001-00010" @default.
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