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- W2921448367 abstract "Abstract DNA polymerase iota (Polι) belongs to the Y-family of DNA polymerases that are involved in DNA damage tolerance through their role in translesion DNA synthesis. Like all other Y-family polymerases, Polι interacts with proliferating cell nuclear antigen (PCNA), Rev1, ubiquitin and ubiquitinated-PCNA and is also ubiquitinated itself. Here, we report that Polι also interacts with the p300 acetyltransferase and is acetylated. The primary acetylation site is K550, located in the Rev1-interacting region. However, K550 amino acid substitutions have no effect on Polι’s ability to interact with Rev1. Interestingly, we find that acetylation of Polι significantly and specifically increases in response to S N 2 alkylating agents and to a lower extent to S N 1 alkylating and oxidative agents. As we have not observed acetylation of Polι’s closest paralogue, DNA polymerase eta (Polη), with which Polι shares many functional similarities, we believe that this modification might exclusively regulate yet to be determined, and separate function(s) of Polι." @default.
- W2921448367 created "2019-03-22" @default.
- W2921448367 creator A5003311245 @default.
- W2921448367 creator A5005915399 @default.
- W2921448367 creator A5047432465 @default.
- W2921448367 creator A5054718611 @default.
- W2921448367 creator A5055680087 @default.
- W2921448367 creator A5061561921 @default.
- W2921448367 creator A5085630627 @default.
- W2921448367 date "2019-03-18" @default.
- W2921448367 modified "2023-10-16" @default.
- W2921448367 title "DNA polymerase ι is acetylated in response to SN2 alkylating agents" @default.
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