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- W2921488499 abstract "Abstract Evaluating odor blends in sensory processing is a crucial step for signal recognition and execution of behavioral decisions. Using behavioral assays and 2-photon imaging, we have characterized the neural and behavioral correlates of mixture perception in the olfactory system of Drosophila . Mixtures of odors with opposing valences elicit strong inhibition in certain attractant-responsive input channels. This inhibition correlates with reduced behavioral attraction. We demonstrate that defined subsets of GABAergic interneurons provide the neuronal substrate of this computation at pre- and postsynaptic loci via GABA B - and GABA A receptors, respectively. Intriguingly, manipulation of single input channels by silencing and optogenetic activation unveils a glomerulus-specific crosstalk between the attractant- and repellent-responsive circuits. This inhibitory interaction biases the behavioral output. Such a form of selective lateral inhibition represents a crucial neuronal mechanism in the processing of conflicting sensory information." @default.
- W2921488499 created "2019-03-22" @default.
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- W2921488499 date "2019-03-13" @default.
- W2921488499 modified "2023-10-17" @default.
- W2921488499 title "Odor mixtures of opposing valence unveil inter-glomerular crosstalk in the Drosophila antennal lobe" @default.
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- W2921488499 doi "https://doi.org/10.1038/s41467-019-09069-1" @default.
- W2921488499 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6416470" @default.
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