FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2921504422> ?p ?o ?g. }

• W2921504422 endingPage "689" @default.
• W2921504422 startingPage "680" @default.
• W2921504422 abstract "Background: Several patients experience persistent otorrhea after a flawless surgical procedure because of insufficient epithelial healing. Several efforts, such as autologous tissue allograft and xenograft, have been made to halt otorrhea. However, a stable technology to induce temporal epithelial repair is yet to be established. Therefore, this study aims to investigate whether implantation of seeding adipose-derived mesenchymal stem cell (ADMSC) aggregates on extracellular matrix (ECM; herein, ADMSC aggregate-ECM) into damaged skin wound promotes skin regeneration. Methods: ADMSC aggregate-ECM was prepared using a previously described procedure that isolated ADMSCs from rabbits and applied to the auricle and auditory meatus wound beds of New Zealand white rabbits. Wound healing was assessed by general observation and hematoxylin and eosin (H&E) staining. Secretion of growth factor of the tissue was evaluated by western blotting. Two other groups, namely, ECM and control, were used. Comparisons of three groups were conducted by one-way analysis of variance analysis. Results: ADMSCs adhered tightly to the ECM and quickly formed cell sheets. At 2 weeks, general observation and H&E staining indicated that the wound healing rates in the ADMSC aggregate-ECM (69.02 ± 6.36%) and ECM (59.32 ± 4.10%) groups were higher than that in the control group (43.74 ± 12.15%; P = 0.005, P < 0.001, respectively) in ear auricle excisional wounds. At 7 weeks, The scar elevation index was evidently reduced in the ADMSC aggregate-ECM (2.08 ± 0.87) and ECM (2.31 ± 0.33) groups compared with the control group (4.06 ± 0.45; P < 0.001, P < 0.001, respectively). In addition, the scar elevation index of the ADMSC aggregate-ECM group reached the lowest rate 4 weeks in advance. In auditory meatus excisional wounds, the ADMSC aggregate-ECM group had the largest range of normal skin-like structure at 4 weeks. The ADMSC aggregate–ECM and ECM groups secreted increased amounts of growth factors that contributed to skin regeneration at weeks 1 and 2, respectively. Conclusions: ADMSC aggregate-ECM and ECM are effective repair materials for wound healing, especially ADMSC aggregate-ECM. This approach will provide a meaningful experimental basis for mastoid epithelium repair in subsequent clinical trials." @default.
• W2921504422 created "2019-03-22" @default.
• W2921504422 creator A5016875703 @default.
• W2921504422 creator A5025726576 @default.
• W2921504422 creator A5072730673 @default.
• W2921504422 date "2019-03-20" @default.
• W2921504422 modified "2023-09-23" @default.
• W2921504422 title "Epithelial defect repair in the auricle and auditory meatus by grafting with cultured adipose-derived mesenchymal stem cell aggregate-extracellular matrix" @default.
• W2921504422 cites W107563536 @default.
• W2921504422 cites W1516324696 @default.
• W2921504422 cites W1973259932 @default.
• W2921504422 cites W1975877255 @default.
• W2921504422 cites W1976147120 @default.
• W2921504422 cites W1982789137 @default.
• W2921504422 cites W1982815250 @default.
• W2921504422 cites W2001147593 @default.
• W2921504422 cites W2002230244 @default.
• W2921504422 cites W2005305730 @default.
• W2921504422 cites W2010545661 @default.
• W2921504422 cites W2012124754 @default.
• W2921504422 cites W2012478243 @default.
• W2921504422 cites W2015501378 @default.
• W2921504422 cites W2017340724 @default.
• W2921504422 cites W2028702444 @default.
• W2921504422 cites W2029927816 @default.
• W2921504422 cites W2031663540 @default.
• W2921504422 cites W2032965689 @default.
• W2921504422 cites W2041983460 @default.
• W2921504422 cites W2048437094 @default.
• W2921504422 cites W2051031054 @default.
• W2921504422 cites W2055534393 @default.
• W2921504422 cites W2058334961 @default.
• W2921504422 cites W2060472428 @default.
• W2921504422 cites W2071718217 @default.
• W2921504422 cites W2080534456 @default.
• W2921504422 cites W2082092885 @default.
• W2921504422 cites W2084288213 @default.
• W2921504422 cites W2100343739 @default.
• W2921504422 cites W2105630570 @default.
• W2921504422 cites W2106675973 @default.
• W2921504422 cites W2111711916 @default.
• W2921504422 cites W2116397695 @default.
• W2921504422 cites W2132584956 @default.
• W2921504422 cites W2137961713 @default.
• W2921504422 cites W2229807784 @default.
• W2921504422 cites W2324492433 @default.
• W2921504422 cites W2412220007 @default.
• W2921504422 cites W2588004094 @default.
• W2921504422 cites W4230197014 @default.
• W2921504422 cites W4230240787 @default.
• W2921504422 cites W835409473 @default.
• W2921504422 cites W2413685079 @default.
• W2921504422 doi "https://doi.org/10.1097/cm9.0000000000000125" @default.
• W2921504422 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6416031" @default.
• W2921504422 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30855349" @default.
• W2921504422 hasPublicationYear "2019" @default.
• W2921504422 type Work @default.
• W2921504422 sameAs 2921504422 @default.
• W2921504422 citedByCount "3" @default.
• W2921504422 countsByYear W29215044222020 @default.
• W2921504422 countsByYear W29215044222021 @default.
• W2921504422 countsByYear W29215044222023 @default.
• W2921504422 crossrefType "journal-article" @default.
• W2921504422 hasAuthorship W2921504422A5016875703 @default.
• W2921504422 hasAuthorship W2921504422A5025726576 @default.
• W2921504422 hasAuthorship W2921504422A5072730673 @default.
• W2921504422 hasBestOaLocation W29215044221 @default.
• W2921504422 hasConcept C105702510 @default.
• W2921504422 hasConcept C125473707 @default.
• W2921504422 hasConcept C126322002 @default.
• W2921504422 hasConcept C141071460 @default.
• W2921504422 hasConcept C142724271 @default.
• W2921504422 hasConcept C171056886 @default.
• W2921504422 hasConcept C171089720 @default.
• W2921504422 hasConcept C189165786 @default.
• W2921504422 hasConcept C198826908 @default.
• W2921504422 hasConcept C2780269544 @default.
• W2921504422 hasConcept C2780801906 @default.
• W2921504422 hasConcept C28328180 @default.
• W2921504422 hasConcept C71924100 @default.
• W2921504422 hasConcept C74864618 @default.
• W2921504422 hasConcept C86803240 @default.
• W2921504422 hasConcept C95444343 @default.
• W2921504422 hasConceptScore W2921504422C105702510 @default.
• W2921504422 hasConceptScore W2921504422C125473707 @default.
• W2921504422 hasConceptScore W2921504422C126322002 @default.
• W2921504422 hasConceptScore W2921504422C141071460 @default.
• W2921504422 hasConceptScore W2921504422C142724271 @default.
• W2921504422 hasConceptScore W2921504422C171056886 @default.
• W2921504422 hasConceptScore W2921504422C171089720 @default.
• W2921504422 hasConceptScore W2921504422C189165786 @default.
• W2921504422 hasConceptScore W2921504422C198826908 @default.
• W2921504422 hasConceptScore W2921504422C2780269544 @default.
• W2921504422 hasConceptScore W2921504422C2780801906 @default.
• W2921504422 hasConceptScore W2921504422C28328180 @default.
• W2921504422 hasConceptScore W2921504422C71924100 @default.
• W2921504422 hasConceptScore W2921504422C74864618 @default.
• W2921504422 hasConceptScore W2921504422C86803240 @default.

• next