FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2921528586> ?p ?o ?g. }

• W2921528586 abstract "Triptolide (TPL), an extract of the Chinese herb Tripterygium wilfordii Hook F, is a potent anti-inflammatory agent that further possesses anticancer activity. Its antiproliferative effects are well established. Only few studies have focused on TPL as a potential treatment in multiple myeloma (MM). In the current study, bone marrow-derived mesenchymal stem cells (BMMSCs) from patients with MM were isolated and treated with TPL at varying concentrations. Thalidomide is currently used as a positive control drug in the treatment of MM. Cell Counting kit-8 assays were performed to assess proliferation activity and flow cytometry with Annexin V-fluorescein/propidium iodide was used to detect cell apoptosis of TPL-treated BMMSCs. Reverse transcription-quantitative polymerase chain reaction assays were applied to measure interleukin (IL)-6, IL-1β and stem cell factor (SCF or Kit ligand) mRNA expression and western blot assays were performed to analyze transcription factor p65 (P65) expression in TPL-treated BMMSCs. ELISA was applied to measure vascular endothelial growth factor (VEGF) levels in the supernatant of the cultured and treated BMMSCs. TPL treatment significantly inhibited BMMSC proliferation compared with the untreated control (P<0.05). At 48 h following TPL treatment, a Cell Counting kit-8 study was performed and the IC50 value was determined at 101.55±2.45 ng/ml. Apoptotic rates were observed to increase with increasing concentrations of TPL (P<0.001), and IL-6, IL-1β and SCF mRNA expression was significantly decreased with increasing TPL (P<0.001). P65 expression following TPL treatment was significantly decreased compared with the untreated control (P<0.05). VEGF levels were significantly reduced in the presence of increasing amounts of TPL (P<0.05). These findings suggest that TPL inhibited BMMSC growth and improved the bone marrow hematopoietic microenvironment by decreasing IL-6, IL-1β and SCF mRNA expression, subsequently inhibiting the proliferation of MM cells. Therefore, TPL may be used in the future to treat patients with MM." @default.
• W2921528586 created "2019-03-22" @default.
• W2921528586 creator A5036353843 @default.
• W2921528586 creator A5037507969 @default.
• W2921528586 creator A5051782566 @default.
• W2921528586 creator A5054367071 @default.
• W2921528586 creator A5054991505 @default.
• W2921528586 creator A5070873093 @default.
• W2921528586 creator A5081281154 @default.
• W2921528586 creator A5089695308 @default.
• W2921528586 creator A5091146731 @default.
• W2921528586 creator A5026591783 @default.
• W2921528586 date "2019-03-12" @default.
• W2921528586 modified "2023-09-30" @default.
• W2921528586 title "Effects of triptolide on bone marrow‑derived mesenchymal stem cells from patients with multiple myeloma" @default.
• W2921528586 cites W1428591431 @default.
• W2921528586 cites W1582656774 @default.
• W2921528586 cites W164958472 @default.
• W2921528586 cites W1882935131 @default.
• W2921528586 cites W1975982325 @default.
• W2921528586 cites W1981876883 @default.
• W2921528586 cites W1986670095 @default.
• W2921528586 cites W1989021153 @default.
• W2921528586 cites W1989116049 @default.
• W2921528586 cites W2005003513 @default.
• W2921528586 cites W2010552629 @default.
• W2921528586 cites W2015319694 @default.
• W2921528586 cites W2022530652 @default.
• W2921528586 cites W2022661105 @default.
• W2921528586 cites W2029047196 @default.
• W2921528586 cites W2032067417 @default.
• W2921528586 cites W2040614757 @default.
• W2921528586 cites W2050329705 @default.
• W2921528586 cites W2054793094 @default.
• W2921528586 cites W2056756517 @default.
• W2921528586 cites W2059459946 @default.
• W2921528586 cites W2063355387 @default.
• W2921528586 cites W2065214439 @default.
• W2921528586 cites W2068578858 @default.
• W2921528586 cites W2084594085 @default.
• W2921528586 cites W2086591577 @default.
• W2921528586 cites W2087952915 @default.
• W2921528586 cites W2107277218 @default.
• W2921528586 cites W2121487239 @default.
• W2921528586 cites W2126369996 @default.
• W2921528586 cites W2144538538 @default.
• W2921528586 cites W2144728882 @default.
• W2921528586 cites W2150821792 @default.
• W2921528586 cites W2163166029 @default.
• W2921528586 cites W2287074867 @default.
• W2921528586 cites W2336066897 @default.
• W2921528586 cites W2410274060 @default.
• W2921528586 cites W2414765276 @default.
• W2921528586 cites W2751936412 @default.
• W2921528586 cites W311467598 @default.
• W2921528586 cites W6760901 @default.
• W2921528586 cites W1964184380 @default.
• W2921528586 doi "https://doi.org/10.3892/etm.2019.7373" @default.
• W2921528586 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6447813" @default.
• W2921528586 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30988704" @default.
• W2921528586 hasPublicationYear "2019" @default.
• W2921528586 type Work @default.
• W2921528586 sameAs 2921528586 @default.
• W2921528586 citedByCount "1" @default.
• W2921528586 countsByYear W29215285862022 @default.
• W2921528586 crossrefType "journal-article" @default.
• W2921528586 hasAuthorship W2921528586A5026591783 @default.
• W2921528586 hasAuthorship W2921528586A5036353843 @default.
• W2921528586 hasAuthorship W2921528586A5037507969 @default.
• W2921528586 hasAuthorship W2921528586A5051782566 @default.
• W2921528586 hasAuthorship W2921528586A5054367071 @default.
• W2921528586 hasAuthorship W2921528586A5054991505 @default.
• W2921528586 hasAuthorship W2921528586A5070873093 @default.
• W2921528586 hasAuthorship W2921528586A5081281154 @default.
• W2921528586 hasAuthorship W2921528586A5089695308 @default.
• W2921528586 hasAuthorship W2921528586A5091146731 @default.
• W2921528586 hasBestOaLocation W29215285861 @default.
• W2921528586 hasConcept C153911025 @default.
• W2921528586 hasConcept C167734588 @default.
• W2921528586 hasConcept C185592680 @default.
• W2921528586 hasConcept C190283241 @default.
• W2921528586 hasConcept C198826908 @default.
• W2921528586 hasConcept C201750760 @default.
• W2921528586 hasConcept C2022786 @default.
• W2921528586 hasConcept C203014093 @default.
• W2921528586 hasConcept C2775934118 @default.
• W2921528586 hasConcept C2776364478 @default.
• W2921528586 hasConcept C2777025900 @default.
• W2921528586 hasConcept C2780007613 @default.
• W2921528586 hasConcept C2781164371 @default.
• W2921528586 hasConcept C28328180 @default.
• W2921528586 hasConcept C29537977 @default.
• W2921528586 hasConcept C31573885 @default.
• W2921528586 hasConcept C502942594 @default.
• W2921528586 hasConcept C553184892 @default.
• W2921528586 hasConcept C55493867 @default.
• W2921528586 hasConcept C62112901 @default.
• W2921528586 hasConcept C86803240 @default.
• W2921528586 hasConcept C95444343 @default.
• W2921528586 hasConceptScore W2921528586C153911025 @default.

• next