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• W2921548359 endingPage "1229" @default.
• W2921548359 startingPage "1214" @default.
• W2921548359 abstract "Correct wiring in the neocortex requires that responses to an individual guidance cue vary among neurons in the same location, and within the same neuron over time. Nestin is an atypical intermediate filament expressed strongly in neural progenitors and is thus used widely as a progenitor marker. Here we show a subpopulation of embryonic cortical neurons that transiently express nestin in their axons. Nestin expression is thus not restricted to neural progenitors, but persists for 2–3 d at lower levels in newborn neurons. We found that nestin-expressing neurons have smaller growth cones, suggesting that nestin affects cytoskeletal dynamics. Nestin, unlike other intermediate filament subtypes, regulates cdk5 kinase by binding the cdk5 activator p35. Cdk5 activity is induced by the repulsive guidance cue Semaphorin3a (Sema3a), leading to axonal growth cone collapse in vitro. Therefore, we tested whether nestin-expressing neurons showed altered responses to Sema3a. We find that nestin-expressing newborn neurons are more sensitive to Sema3a in a roscovitine-sensitive manner, whereas nestin knockdown results in lowered sensitivity to Sema3a. We propose that nestin functions in immature neurons to modulate cdk5 downstream of the Sema3a response. Thus, the transient expression of nestin could allow temporal and/or spatial modulation of a neuron’s response to Sema3a, particularly during early axon guidance." @default.
• W2921548359 created "2019-03-22" @default.
• W2921548359 creator A5003424762 @default.
• W2921548359 creator A5010323576 @default.
• W2921548359 creator A5036479370 @default.
• W2921548359 creator A5047048387 @default.
• W2921548359 creator A5048926764 @default.
• W2921548359 creator A5086639012 @default.
• W2921548359 date "2019-05-01" @default.
• W2921548359 modified "2023-10-15" @default.
• W2921548359 title "Nestin in immature embryonic neurons affects axon growth cone morphology and Semaphorin3a sensitivity" @default.
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