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- W2921585424 abstract "In 2013, the Food and Drug Administration (FDA) approved Collagenase Clostridium histolyticum (CCH; Xiaflex; Endo Pharmaceuticals; Malvern, PA, USA) for Peyronie’s disease (PD) after data from a Phase III trial data showed significant improvements in patient bother and penile curvature over placebo (17 degrees vs 9 degrees; P < .0001).1 Several clinical studies have corroborated these findings, although a recent report showed less encouraging results, with a mean improvement of only 5 degrees.2 It appears that CCH has ushered in a new era in PD management, and there is a trend toward greater use of nonsurgical therapies. In fact, a recent survey from the International Society of Sexual Medicine suggested that a minority of surgeons (<10%–15%) perform >20 penile straightening procedures per year, even among those with expertise in sexual medicine.3 The ideal treatment plan is determined through a partnership between the patient and provider, and the best opportunity to establish this partnership is during the initial patient encounter. Ultimately, this has important treatment implications, and patient selection is the key to optimizing outcomes with CCH and other PD treatments. A one-size-fits-all treatment approach does not account for important factors gleaned through a thoughtful and thorough history, physical examination, and adjunctive testing. However, it is clear from clinical practice that there is a lack of consensus regarding the initial evaluation of patients with PD. Here we describe our standardized approach to the initial evaluation for PD in the modern era and briefly discuss several treatment considerations based on this workup." @default.
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- W2921585424 date "2019-03-06" @default.
- W2921585424 modified "2023-10-11" @default.
- W2921585424 title "A Modern Approach to the Clinical Evaluation of Peyronie’s Disease in the Era of Collagenase" @default.
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- W2921585424 doi "https://doi.org/10.1016/j.jsxm.2019.02.004" @default.
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