FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2921591738> ?p ?o ?g. }

• W2921591738 abstract "Abstract The maintenance of the myelin sheath by Schwann cells around peripheral nerve axons is essential for the rapid propagation of action potentials. A large number of peripheral neuropathies results for the loss of this myelin sheath, a process called demyelination. Demyelination is a program of cell dedifferentiation characterized by reprograming and several catabolic and anabolic events. This process was best characterized in Wallerian demyelination that occurs following nerve injury. In this model, the earliest well characterized steps are MAPK pathways activation and cJun phosphorylation and nuclear localization starting around 4hrs after nerve injury. Here we show, using in vivo imaging of virally-delivered fluorescent probes to mitochondria, that Schwann cell mitochondria pH, motility and calcium are altered as soon as 1hr after nerve injury. Mitochondrial calcium release through VDAC1 mitochondrial channel and mPTP directly induced Schwann cell demyelination via MAPK and c-Jun activation. Decreasing mitochondrial calcium release through VDAC1 silencing or TRO19622 blocking prevented MAPK and cJun activation and demyelination. VDAC1 opening with Methyl Jasmonate induced these cellular mechanisms in absence of nerve injury. Taken together, these data indicate that mitochondria calcium homeostasis through VDAC1 is instrumental in the Schwann cell demyelination process and therefore provide a molecular basis for an anti-demyelinating drug approach." @default.
• W2921591738 created "2019-03-22" @default.
• W2921591738 creator A5006273703 @default.
• W2921591738 creator A5047195620 @default.
• W2921591738 creator A5053806374 @default.
• W2921591738 creator A5060347222 @default.
• W2921591738 creator A5062263080 @default.
• W2921591738 creator A5088177254 @default.
• W2921591738 date "2019-03-18" @default.
• W2921591738 modified "2023-10-01" @default.
• W2921591738 title "Schwann cell demyelination is triggered by a transient mitochondrial calcium release through Voltage Dependent Anion Channel 1" @default.
• W2921591738 cites W1512324842 @default.
• W2921591738 cites W1965571714 @default.
• W2921591738 cites W1967223729 @default.
• W2921591738 cites W1969115683 @default.
• W2921591738 cites W1969821478 @default.
• W2921591738 cites W1969850018 @default.
• W2921591738 cites W1971760726 @default.
• W2921591738 cites W1972801090 @default.
• W2921591738 cites W1973009368 @default.
• W2921591738 cites W1975324741 @default.
• W2921591738 cites W1992622882 @default.
• W2921591738 cites W1995717532 @default.
• W2921591738 cites W2001024287 @default.
• W2921591738 cites W2008235034 @default.
• W2921591738 cites W2009693908 @default.
• W2921591738 cites W2018978435 @default.
• W2921591738 cites W2022084199 @default.
• W2921591738 cites W2025639657 @default.
• W2921591738 cites W2049015703 @default.
• W2921591738 cites W2057710663 @default.
• W2921591738 cites W2063206709 @default.
• W2921591738 cites W2064713079 @default.
• W2921591738 cites W2068766234 @default.
• W2921591738 cites W2069083337 @default.
• W2921591738 cites W2076728391 @default.
• W2921591738 cites W2078320082 @default.
• W2921591738 cites W2079761925 @default.
• W2921591738 cites W2085029391 @default.
• W2921591738 cites W2090177945 @default.
• W2921591738 cites W2095464946 @default.
• W2921591738 cites W2096027130 @default.
• W2921591738 cites W2099962956 @default.
• W2921591738 cites W2101300328 @default.
• W2921591738 cites W2120442017 @default.
• W2921591738 cites W2121808182 @default.
• W2921591738 cites W2122210858 @default.
• W2921591738 cites W2130460161 @default.
• W2921591738 cites W2141599743 @default.
• W2921591738 cites W2142773795 @default.
• W2921591738 cites W2144569256 @default.
• W2921591738 cites W2163360776 @default.
• W2921591738 cites W2165601218 @default.
• W2921591738 cites W2333901407 @default.
• W2921591738 cites W2396814975 @default.
• W2921591738 cites W2498785491 @default.
• W2921591738 cites W2624598325 @default.
• W2921591738 cites W2761962880 @default.
• W2921591738 cites W2886626802 @default.
• W2921591738 cites W2899327057 @default.
• W2921591738 cites W4253422011 @default.
• W2921591738 cites W4255760236 @default.
• W2921591738 cites W931085338 @default.
• W2921591738 doi "https://doi.org/10.1101/581157" @default.
• W2921591738 hasPublicationYear "2019" @default.
• W2921591738 type Work @default.
• W2921591738 sameAs 2921591738 @default.
• W2921591738 citedByCount "0" @default.
• W2921591738 crossrefType "posted-content" @default.
• W2921591738 hasAuthorship W2921591738A5006273703 @default.
• W2921591738 hasAuthorship W2921591738A5047195620 @default.
• W2921591738 hasAuthorship W2921591738A5053806374 @default.
• W2921591738 hasAuthorship W2921591738A5060347222 @default.
• W2921591738 hasAuthorship W2921591738A5062263080 @default.
• W2921591738 hasAuthorship W2921591738A5088177254 @default.
• W2921591738 hasBestOaLocation W29215917381 @default.
• W2921591738 hasConcept C104317684 @default.
• W2921591738 hasConcept C146587185 @default.
• W2921591738 hasConcept C169760540 @default.
• W2921591738 hasConcept C178790620 @default.
• W2921591738 hasConcept C185592680 @default.
• W2921591738 hasConcept C2775991916 @default.
• W2921591738 hasConcept C2777004073 @default.
• W2921591738 hasConcept C2778609137 @default.
• W2921591738 hasConcept C2779058106 @default.
• W2921591738 hasConcept C2780862704 @default.
• W2921591738 hasConcept C28859421 @default.
• W2921591738 hasConcept C519063684 @default.
• W2921591738 hasConcept C529278444 @default.
• W2921591738 hasConcept C547475151 @default.
• W2921591738 hasConcept C55493867 @default.
• W2921591738 hasConcept C85520022 @default.
• W2921591738 hasConcept C86803240 @default.
• W2921591738 hasConcept C95444343 @default.
• W2921591738 hasConceptScore W2921591738C104317684 @default.
• W2921591738 hasConceptScore W2921591738C146587185 @default.
• W2921591738 hasConceptScore W2921591738C169760540 @default.
• W2921591738 hasConceptScore W2921591738C178790620 @default.
• W2921591738 hasConceptScore W2921591738C185592680 @default.
• W2921591738 hasConceptScore W2921591738C2775991916 @default.

• next