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- W2921605360 abstract "The consistent decline in critical illness mortality has a significant effect on trial design, whereby either an improbable effect sizes or large number of patients are required.The signal-to-noise ratio is of particular interest for the critically ill. When considering the potential signal, interventions need to match outcomes in regard to biological plausibility. Provision of nutrition is a complex decision with many underappreciated aspects of noise. However, a fundamental interaction is often not accounted for time.Working as a community to evolve trial design will be our challenge for nutrition interventions in the critically ill for the future." @default.
- W2921605360 created "2019-03-22" @default.
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- W2921605360 date "2019-02-19" @default.
- W2921605360 modified "2023-09-25" @default.
- W2921605360 title "Designing nutrition-based interventional trials for the future: addressing the known knowns" @default.
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- W2921605360 doi "https://doi.org/10.1186/s13054-019-2345-5" @default.
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