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• W2921619174 endingPage "348" @default.
• W2921619174 startingPage "342" @default.
• W2921619174 abstract "Background: Liver kinase B1 (LKB1)/5’-adenosine monophosphate-activated protein kinase (AMPK) signaling, a metabolic checkpoint, plays a neuro-protective role in the pathogenesis of Alzheimer’s disease (AD). Amyloid-β (Aβ) acts as a classical biomarker of AD. The aim of the present study was to explore whether berberine (BBR) activates LKB1/AMPK signaling and ameliorates Aβ pathology. Methods: The Aβ levels were detected using enzyme-linked immunosorbent assay and immunohistochemistry. The following biomarkers were measured by Western blotting: phosphorylated (p-) LKB1 (Ser334 and Thr189), p-AMPK (AMPKα and AMPKβ1), synaptophysin, post-synaptic density protein 95 and p-cAMP-response element binding protein (p-CREB). The glial fibrillary acidic protein (GFAP) was determined using Western blotting and immunohistochemistry. Results: BBR inhibited Aβ expression in the brain of APP/PS1 mice. There was a strong up-regulation of both p-LKB1 (Ser334 and Thr189) and p-AMPK (AMPKα and AMPKβ1) in the brains of APP/PS1 transgenic mice after BBR-treatment (P<0.01). BBR promoted the expression of synaptophysin, post-synaptic density protein 95 and p-CREB(Ser133) in the AD brain, compared with the model mice. Conclusion: BBR alleviates Aβ pathogenesis and rescues synapse damage via activating LKB1/AMPK signaling in the brain of APP/PS1 transgenic mice." @default.
• W2921619174 created "2019-03-22" @default.
• W2921619174 creator A5021334306 @default.
• W2921619174 creator A5051252569 @default.
• W2921619174 creator A5061573836 @default.
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• W2921619174 date "2019-06-20" @default.
• W2921619174 modified "2023-10-18" @default.
• W2921619174 title "Berberine Alleviates Amyloid-beta Pathogenesis Via Activating LKB1/AMPK Signaling in the Brain of APP/PS1 Transgenic Mice" @default.
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• W2921619174 doi "https://doi.org/10.2174/1566524019666190315164120" @default.
• W2921619174 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30873920" @default.
• W2921619174 hasPublicationYear "2019" @default.
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