Matches in SemOpenAlex for { <https://semopenalex.org/work/W2921664132> ?p ?o ?g. }
- W2921664132 endingPage "71" @default.
- W2921664132 startingPage "63" @default.
- W2921664132 abstract "The ability to learn that a stimulus no longer signals danger is known as extinction. A major characteristic of extinction is that it is context-dependent, which means that fear reduction only occurs in the same context as extinction training. In other contexts, there is re-emergence of fear, known as contextual renewal. The ability to properly extinguish fear memories and generalize safety associations to multiple contexts provides therapeutic potential, but little is known about the specific neural pathways that mediate fear renewal and extinction generalization. The ventral hippocampus (VH) is thought to provide a contextual gating mechanism that determines whether fear or safety is expressed in particular contexts through its projections to areas of the fear circuit, including the infralimbic (IL) and prelimbic (PL) cortices. Moreover, VH principal cells fire in large, overlapping regions of the environment, a characteristic that is ideal to support generalization; yet it is unclear how different projection cells mediate this process. Using a pathway-specific (intersectional) chemogenetic approach, we demonstrate that selective activation of VH cells projecting to PL attenuates fear renewal without affecting fear expression. These results have implications for anxiety disorders since they uncover a neural pathway associated with extinction generalization." @default.
- W2921664132 created "2019-03-22" @default.
- W2921664132 creator A5001695399 @default.
- W2921664132 creator A5043546771 @default.
- W2921664132 creator A5050960510 @default.
- W2921664132 creator A5062563917 @default.
- W2921664132 creator A5070505880 @default.
- W2921664132 creator A5077161342 @default.
- W2921664132 date "2019-05-01" @default.
- W2921664132 modified "2023-10-14" @default.
- W2921664132 title "Pathway specific activation of ventral hippocampal cells projecting to the prelimbic cortex diminishes fear renewal" @default.
- W2921664132 cites W1525373779 @default.
- W2921664132 cites W1934338242 @default.
- W2921664132 cites W1945262540 @default.
- W2921664132 cites W1963854355 @default.
- W2921664132 cites W1965523485 @default.
- W2921664132 cites W1972434093 @default.
- W2921664132 cites W1980796284 @default.
- W2921664132 cites W1981032252 @default.
- W2921664132 cites W1983090694 @default.
- W2921664132 cites W1984506322 @default.
- W2921664132 cites W1985360793 @default.
- W2921664132 cites W1986778626 @default.
- W2921664132 cites W1988193688 @default.
- W2921664132 cites W1989757714 @default.
- W2921664132 cites W1990268876 @default.
- W2921664132 cites W1990397347 @default.
- W2921664132 cites W1992402923 @default.
- W2921664132 cites W1997097282 @default.
- W2921664132 cites W1998146045 @default.
- W2921664132 cites W2002459043 @default.
- W2921664132 cites W2005020790 @default.
- W2921664132 cites W2007200002 @default.
- W2921664132 cites W2008936540 @default.
- W2921664132 cites W2012639198 @default.
- W2921664132 cites W2017169966 @default.
- W2921664132 cites W2019438546 @default.
- W2921664132 cites W2020972983 @default.
- W2921664132 cites W2031167848 @default.
- W2921664132 cites W2035541070 @default.
- W2921664132 cites W2038693055 @default.
- W2921664132 cites W2044150847 @default.
- W2921664132 cites W2045187579 @default.
- W2921664132 cites W2049115098 @default.
- W2921664132 cites W2049549817 @default.
- W2921664132 cites W2049856816 @default.
- W2921664132 cites W2055766556 @default.
- W2921664132 cites W2060685017 @default.
- W2921664132 cites W2066170543 @default.
- W2921664132 cites W2068134369 @default.
- W2921664132 cites W2069879709 @default.
- W2921664132 cites W2072060777 @default.
- W2921664132 cites W2075665234 @default.
- W2921664132 cites W2076471532 @default.
- W2921664132 cites W2080737970 @default.
- W2921664132 cites W2083167011 @default.
- W2921664132 cites W2083982771 @default.
- W2921664132 cites W2087129491 @default.
- W2921664132 cites W2087527212 @default.
- W2921664132 cites W2096032973 @default.
- W2921664132 cites W2108888119 @default.
- W2921664132 cites W2110172120 @default.
- W2921664132 cites W2111977586 @default.
- W2921664132 cites W2113763432 @default.
- W2921664132 cites W2115271248 @default.
- W2921664132 cites W2116330286 @default.
- W2921664132 cites W2127967352 @default.
- W2921664132 cites W2129523889 @default.
- W2921664132 cites W2131462031 @default.
- W2921664132 cites W2137435206 @default.
- W2921664132 cites W2142925815 @default.
- W2921664132 cites W2145465887 @default.
- W2921664132 cites W2146312614 @default.
- W2921664132 cites W2162894081 @default.
- W2921664132 cites W2163918857 @default.
- W2921664132 cites W2327039089 @default.
- W2921664132 cites W2327203721 @default.
- W2921664132 cites W2410542938 @default.
- W2921664132 cites W2534021820 @default.
- W2921664132 cites W2550420719 @default.
- W2921664132 cites W2552071159 @default.
- W2921664132 cites W2604552291 @default.
- W2921664132 cites W2604657615 @default.
- W2921664132 cites W2610248919 @default.
- W2921664132 cites W2797856206 @default.
- W2921664132 cites W2803095608 @default.
- W2921664132 cites W2889746013 @default.
- W2921664132 cites W2910049926 @default.
- W2921664132 cites W4232124488 @default.
- W2921664132 cites W4232755968 @default.
- W2921664132 cites W4234634496 @default.
- W2921664132 cites W4246418495 @default.
- W2921664132 cites W4251351176 @default.
- W2921664132 doi "https://doi.org/10.1016/j.nlm.2019.03.003" @default.
- W2921664132 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6736601" @default.
- W2921664132 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30898692" @default.
- W2921664132 hasPublicationYear "2019" @default.
- W2921664132 type Work @default.