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• W2921670241 abstract "The length of untranslated regions at the 3’ end of transcripts (3’UTRs) is regulated by alternate polyadenylation (APA). 3’UTRs contain regions that harbor binding motifs for regulatory molecules. However, the mechanisms that coordinate the 3’UTR length of specific groups of transcripts are not well understood. We therefore developed a method, CSI-UTR, that models 3’UTR structure as tandem segments between functional alternative-polyadenylation sites (termed cleavage site intervals – CSIs). This approach facilitated 1) profiling of 3’UTR isoform expression changes and 2) statistical enrichment of putative regulatory motifs. CSI-UTR analysis is UTR-annotation independent and can interrogate legacy data generated from standard RNA-Seq libraries. CSI-UTR identified a set of CSIs in human and rodent transcriptomes. Analysis of RNA-Seq datasets from neural tissue identified differential expression events within 3’UTRs not detected by standard gene-based differential expression analyses. Further, in many instances 3’UTR and CDS from the same gene were regulated differently. This modulation of motifs for RNA-interacting molecules with potential condition-dependent and tissue-specific RNA binding partners near the polyA signal and CSI junction may play a mechanistic role in the specificity of alternative polyadenylation. Source code, CSI BED files and example datasets are available at: https://github.com/UofLBioinformatics/CSI-UTR" @default.
• W2921670241 created "2019-03-22" @default.
• W2921670241 creator A5006333981 @default.
• W2921670241 creator A5017324963 @default.
• W2921670241 creator A5034707578 @default.
• W2921670241 creator A5036203175 @default.
• W2921670241 creator A5038602012 @default.
• W2921670241 creator A5049304119 @default.
• W2921670241 creator A5054939689 @default.
• W2921670241 creator A5060935645 @default.
• W2921670241 date "2019-03-12" @default.
• W2921670241 modified "2023-10-18" @default.
• W2921670241 title "Detection of Differentially Expressed Cleavage Site Intervals Within 3′ Untranslated Regions Using CSI-UTR Reveals Regulated Interaction Motifs" @default.
• W2921670241 cites W1489054197 @default.
• W2921670241 cites W1528466095 @default.
• W2921670241 cites W1548609921 @default.
• W2921670241 cites W1566430503 @default.
• W2921670241 cites W1666355806 @default.
• W2921670241 cites W1709815505 @default.
• W2921670241 cites W1964727443 @default.
• W2921670241 cites W1965151684 @default.
• W2921670241 cites W1968787976 @default.
• W2921670241 cites W1974379434 @default.
• W2921670241 cites W1975454303 @default.
• W2921670241 cites W1976500290 @default.
• W2921670241 cites W1977889668 @default.
• W2921670241 cites W1982908050 @default.
• W2921670241 cites W1984084985 @default.
• W2921670241 cites W1985701920 @default.
• W2921670241 cites W1994881764 @default.
• W2921670241 cites W1997703164 @default.
• W2921670241 cites W2002555696 @default.
• W2921670241 cites W2002759338 @default.
• W2921670241 cites W2006270268 @default.
• W2921670241 cites W2013313629 @default.
• W2921670241 cites W2018300670 @default.
• W2921670241 cites W2018548355 @default.
• W2921670241 cites W2026663202 @default.
• W2921670241 cites W2029069592 @default.
• W2921670241 cites W2029706883 @default.
• W2921670241 cites W2034355012 @default.
• W2921670241 cites W2036065307 @default.
• W2921670241 cites W2036068585 @default.
• W2921670241 cites W2041675472 @default.
• W2921670241 cites W2043490895 @default.
• W2921670241 cites W2046583421 @default.
• W2921670241 cites W2061748534 @default.
• W2921670241 cites W2063151549 @default.
• W2921670241 cites W2064397275 @default.
• W2921670241 cites W2066231767 @default.
• W2921670241 cites W2067064841 @default.
• W2921670241 cites W2073987430 @default.
• W2921670241 cites W2074501312 @default.
• W2921670241 cites W2080532845 @default.
• W2921670241 cites W2080763471 @default.
• W2921670241 cites W2081012021 @default.
• W2921670241 cites W2085670913 @default.
• W2921670241 cites W2087789109 @default.
• W2921670241 cites W2095930993 @default.
• W2921670241 cites W2099915768 @default.
• W2921670241 cites W2101243275 @default.
• W2921670241 cites W2102278945 @default.
• W2921670241 cites W2102619694 @default.
• W2921670241 cites W2103823493 @default.
• W2921670241 cites W2105545925 @default.
• W2921670241 cites W2108053190 @default.
• W2921670241 cites W2108234281 @default.
• W2921670241 cites W2113310426 @default.
• W2921670241 cites W2116041602 @default.
• W2921670241 cites W2116731299 @default.
• W2921670241 cites W2118031210 @default.
• W2921670241 cites W2118834857 @default.
• W2921670241 cites W2119204091 @default.
• W2921670241 cites W2119601615 @default.
• W2921670241 cites W2119980799 @default.
• W2921670241 cites W2121303536 @default.
• W2921670241 cites W2122575917 @default.
• W2921670241 cites W2123285201 @default.
• W2921670241 cites W2123830992 @default.
• W2921670241 cites W2125850770 @default.
• W2921670241 cites W2126144698 @default.
• W2921670241 cites W2127279968 @default.
• W2921670241 cites W2128016314 @default.
• W2921670241 cites W2131271579 @default.
• W2921670241 cites W2133019267 @default.
• W2921670241 cites W2133082302 @default.
• W2921670241 cites W2135835936 @default.
• W2921670241 cites W2136430672 @default.
• W2921670241 cites W2137307000 @default.
• W2921670241 cites W2140729960 @default.
• W2921670241 cites W2143688190 @default.
• W2921670241 cites W2144137440 @default.
• W2921670241 cites W2145674449 @default.
• W2921670241 cites W2147087089 @default.
• W2921670241 cites W2151562469 @default.
• W2921670241 cites W2159730169 @default.
• W2921670241 cites W2160770405 @default.
• W2921670241 cites W2163533539 @default.
• W2921670241 cites W2169456326 @default.
• W2921670241 cites W2173732482 @default.

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