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• W2921676924 endingPage "e0213839" @default.
• W2921676924 startingPage "e0213839" @default.
• W2921676924 abstract "Posttraumatic stress disorder (PTSD) is associated with impaired major domains of psychology and behavior. Individuals with PTSD also have increased co-morbidity with several serious medical conditions, including autoimmune diseases, cardiovascular disease, and diabetes, raising the possibility that systemic pathology associated with PTSD might be identified by metabolomic analysis of blood. We sought to identify metabolites that are altered in male combat veterans with PTSD. In this case-control study, we compared metabolomic profiles from age-matched male combat trauma-exposed veterans from the Iraq and Afghanistan conflicts with PTSD (n = 52) and without PTSD (n = 51) (‘Discovery group’). An additional group of 31 PTSD-positive and 31 PTSD-negative male combat-exposed veterans was used for validation of these findings (‘Test group’). Plasma metabolite profiles were measured in all subjects using ultrahigh performance liquid chromatography/tandem mass spectrometry and gas chromatography/mass spectrometry. We identified key differences between PTSD subjects and controls in pathways related to glycolysis and fatty acid uptake and metabolism in the initial ‘Discovery group’, consistent with mitochondrial alterations or dysfunction, which were also confirmed in the ‘Test group’. Other pathways related to urea cycle and amino acid metabolism were different between PTSD subjects and controls in the ‘Discovery’ but not in the smaller ‘Test’ group. These metabolic differences were not explained by comorbid major depression, body mass index, blood glucose, hemoglobin A1c, smoking, or use of analgesics, antidepressants, statins, or anti-inflammatories. These data show replicable, wide-ranging changes in the metabolic profile of combat-exposed males with PTSD, with a suggestion of mitochondrial alterations or dysfunction, that may contribute to the behavioral and somatic phenotypes associated with this disease." @default.
• W2921676924 created "2019-03-22" @default.
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• W2921676924 date "2019-03-18" @default.
• W2921676924 modified "2023-10-18" @default.
• W2921676924 title "Metabolomic analysis of male combat veterans with post traumatic stress disorder" @default.
• W2921676924 cites W1417669828 @default.
• W2921676924 cites W144535883 @default.
• W2921676924 cites W1485808996 @default.
• W2921676924 cites W1568705812 @default.
• W2921676924 cites W179761311 @default.
• W2921676924 cites W1865005612 @default.
• W2921676924 cites W1950113474 @default.
• W2921676924 cites W1963588613 @default.
• W2921676924 cites W1964895626 @default.
• W2921676924 cites W1965004625 @default.
• W2921676924 cites W1968566223 @default.
• W2921676924 cites W1968885581 @default.
• W2921676924 cites W1971082249 @default.
• W2921676924 cites W1974438296 @default.
• W2921676924 cites W1977789295 @default.
• W2921676924 cites W1979203936 @default.
• W2921676924 cites W1980270094 @default.
• W2921676924 cites W1985058290 @default.
• W2921676924 cites W1986088683 @default.
• W2921676924 cites W1986674928 @default.
• W2921676924 cites W1987841256 @default.
• W2921676924 cites W1987857702 @default.
• W2921676924 cites W1989875196 @default.
• W2921676924 cites W1989887425 @default.
• W2921676924 cites W1991985856 @default.
• W2921676924 cites W1993010501 @default.
• W2921676924 cites W1993013946 @default.
• W2921676924 cites W1994050387 @default.
• W2921676924 cites W1996576595 @default.
• W2921676924 cites W1997965387 @default.
• W2921676924 cites W1998189365 @default.
• W2921676924 cites W1999332404 @default.
• W2921676924 cites W2001986928 @default.
• W2921676924 cites W2002033816 @default.
• W2921676924 cites W2002162086 @default.
• W2921676924 cites W2003535800 @default.
• W2921676924 cites W2006643119 @default.
• W2921676924 cites W2007543422 @default.
• W2921676924 cites W2008952120 @default.
• W2921676924 cites W2009200566 @default.
• W2921676924 cites W2013555477 @default.
• W2921676924 cites W2013625937 @default.
• W2921676924 cites W2014886061 @default.
• W2921676924 cites W2014988592 @default.
• W2921676924 cites W2017379833 @default.
• W2921676924 cites W2017771330 @default.
• W2921676924 cites W2018883062 @default.
• W2921676924 cites W2019087671 @default.
• W2921676924 cites W2021560133 @default.
• W2921676924 cites W2035026805 @default.
• W2921676924 cites W2035445406 @default.
• W2921676924 cites W2037071915 @default.
• W2921676924 cites W2037841794 @default.
• W2921676924 cites W2037850613 @default.
• W2921676924 cites W2039349691 @default.
• W2921676924 cites W2039883051 @default.
• W2921676924 cites W2041185112 @default.
• W2921676924 cites W2042334736 @default.
• W2921676924 cites W2043275406 @default.
• W2921676924 cites W2046796005 @default.
• W2921676924 cites W2047790936 @default.
• W2921676924 cites W2051822945 @default.
• W2921676924 cites W2052528465 @default.
• W2921676924 cites W2053076410 @default.
• W2921676924 cites W2055733440 @default.
• W2921676924 cites W2057251357 @default.
• W2921676924 cites W2061663331 @default.
• W2921676924 cites W2062420270 @default.
• W2921676924 cites W2062447551 @default.
• W2921676924 cites W2063164149 @default.
• W2921676924 cites W2063913905 @default.
• W2921676924 cites W2065230233 @default.
• W2921676924 cites W2067059164 @default.
• W2921676924 cites W2067898648 @default.
• W2921676924 cites W2072348905 @default.

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