FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2921713103> ?p ?o ?g. }

• W2921713103 endingPage "1237" @default.
• W2921713103 startingPage "1224" @default.
• W2921713103 abstract "In the present study, we investigated a suppressive role of microRNA-596 (miR-596) in gastric cancer (GC). Moreover, the downregulation of miR-596 in GC cell lines was associated with an increase of miR-596 promoter methylation. We also established that miR-596 controls the expression of peroxiredoxin 1 (PRDX1), which has never been reported before, suggesting that this interaction could play an important role in GC progression.To study the potential role and possible regulatory mechanism of miR-596 in GC.The expression levels of miR-596 and PRDX1 in gastric cancer tissues and cell lines were detected by quantitative real-time PCR (qRT-PCR). Western blot and luciferase reporter assay were used to detect the effect of miR-596 on PRDX1 expression. Then, the proliferation, metastasis, and invasion of GC cell lines transfected with miR-596 mimics were analyzed, respectively, by Cell Counting Kit-8 proliferation assay, wound healing assay, and transwell invasion assay. Meanwhile, the methylation status of the promoter CpG islands of miR-596 in GC cell lines was detected by methylation-specific PCR (MSP).Expression of miR-596 was decreased and PRDX1 was upregulated in GC tissues and cell lines. Overexpression of miR-596 decreased the expression of PRDX1 and luciferase reporter assays detected the direct binding of miR-596 to the 3'-untranslated region (UTR) of PRDX1 transcripts. Furthermore, we found that overexpression of miR-596 remarkably suppressed cell proliferation, migration, and invasion in GC cells. We further analyzed miR-596 promoter methylation by MSP and qRT-PCR, and found the downregulation of miR-596 was associated with promoter methylation status in GC cell lines. Moreover, DNA demethylation and reactivation of miR-596 after treatment with 5-Aza-2'-deoxycytidine inhibited the proliferative ability of GC cells.MiR-596 has a tumor suppressive role in GC and is downregulated partly due to promoter hypermethylation. Furthermore, PRDX1 is one of the putative target genes of miR-596." @default.
• W2921713103 created "2019-03-22" @default.
• W2921713103 creator A5040374637 @default.
• W2921713103 creator A5045839676 @default.
• W2921713103 date "2019-03-06" @default.
• W2921713103 modified "2023-10-16" @default.
• W2921713103 title "MicroRNA-596 acts as a tumor suppressor in gastric cancer and is upregulated by promotor demethylation" @default.
• W2921713103 cites W1923263258 @default.
• W2921713103 cites W1997379339 @default.
• W2921713103 cites W2004938056 @default.
• W2921713103 cites W2012511861 @default.
• W2921713103 cites W2015284016 @default.
• W2921713103 cites W2024825778 @default.
• W2921713103 cites W2036982851 @default.
• W2921713103 cites W2046387526 @default.
• W2921713103 cites W2051798434 @default.
• W2921713103 cites W2052665087 @default.
• W2921713103 cites W2068200721 @default.
• W2921713103 cites W2078849828 @default.
• W2921713103 cites W2093203570 @default.
• W2921713103 cites W2093419517 @default.
• W2921713103 cites W2099861627 @default.
• W2921713103 cites W2109227959 @default.
• W2921713103 cites W2113330771 @default.
• W2921713103 cites W2113860045 @default.
• W2921713103 cites W2122672898 @default.
• W2921713103 cites W2124953287 @default.
• W2921713103 cites W2148287035 @default.
• W2921713103 cites W2148660548 @default.
• W2921713103 cites W2148929244 @default.
• W2921713103 cites W2162674813 @default.
• W2921713103 cites W2289875342 @default.
• W2921713103 cites W2302279046 @default.
• W2921713103 cites W2416158141 @default.
• W2921713103 cites W2562067618 @default.
• W2921713103 cites W2567064787 @default.
• W2921713103 cites W2579984888 @default.
• W2921713103 cites W2737891706 @default.
• W2921713103 cites W2744384859 @default.
• W2921713103 cites W2770603707 @default.
• W2921713103 cites W4245800387 @default.
• W2921713103 cites W70692427 @default.
• W2921713103 doi "https://doi.org/10.3748/wjg.v25.i10.1224" @default.
• W2921713103 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6421237" @default.
• W2921713103 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30886505" @default.
• W2921713103 hasPublicationYear "2019" @default.
• W2921713103 type Work @default.
• W2921713103 sameAs 2921713103 @default.
• W2921713103 citedByCount "15" @default.
• W2921713103 countsByYear W29217131032019 @default.
• W2921713103 countsByYear W29217131032020 @default.
• W2921713103 countsByYear W29217131032021 @default.
• W2921713103 countsByYear W29217131032022 @default.
• W2921713103 crossrefType "journal-article" @default.
• W2921713103 hasAuthorship W2921713103A5040374637 @default.
• W2921713103 hasAuthorship W2921713103A5045839676 @default.
• W2921713103 hasBestOaLocation W29217131031 @default.
• W2921713103 hasConcept C101762097 @default.
• W2921713103 hasConcept C104317684 @default.
• W2921713103 hasConcept C111335760 @default.
• W2921713103 hasConcept C127561419 @default.
• W2921713103 hasConcept C145059251 @default.
• W2921713103 hasConcept C150194340 @default.
• W2921713103 hasConcept C153911025 @default.
• W2921713103 hasConcept C161733203 @default.
• W2921713103 hasConcept C190727270 @default.
• W2921713103 hasConcept C2776415932 @default.
• W2921713103 hasConcept C33288867 @default.
• W2921713103 hasConcept C502942594 @default.
• W2921713103 hasConcept C54009773 @default.
• W2921713103 hasConcept C54355233 @default.
• W2921713103 hasConcept C62112901 @default.
• W2921713103 hasConcept C81885089 @default.
• W2921713103 hasConcept C86803240 @default.
• W2921713103 hasConceptScore W2921713103C101762097 @default.
• W2921713103 hasConceptScore W2921713103C104317684 @default.
• W2921713103 hasConceptScore W2921713103C111335760 @default.
• W2921713103 hasConceptScore W2921713103C127561419 @default.
• W2921713103 hasConceptScore W2921713103C145059251 @default.
• W2921713103 hasConceptScore W2921713103C150194340 @default.
• W2921713103 hasConceptScore W2921713103C153911025 @default.
• W2921713103 hasConceptScore W2921713103C161733203 @default.
• W2921713103 hasConceptScore W2921713103C190727270 @default.
• W2921713103 hasConceptScore W2921713103C2776415932 @default.
• W2921713103 hasConceptScore W2921713103C33288867 @default.
• W2921713103 hasConceptScore W2921713103C502942594 @default.
• W2921713103 hasConceptScore W2921713103C54009773 @default.
• W2921713103 hasConceptScore W2921713103C54355233 @default.
• W2921713103 hasConceptScore W2921713103C62112901 @default.
• W2921713103 hasConceptScore W2921713103C81885089 @default.
• W2921713103 hasConceptScore W2921713103C86803240 @default.
• W2921713103 hasIssue "10" @default.
• W2921713103 hasLocation W29217131031 @default.
• W2921713103 hasLocation W29217131032 @default.
• W2921713103 hasLocation W29217131033 @default.
• W2921713103 hasLocation W29217131034 @default.
• W2921713103 hasOpenAccess W2921713103 @default.
• W2921713103 hasPrimaryLocation W29217131031 @default.

• next