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- W2921718013 abstract "Abstract Treatment with cumulative dosages of zoledronic acid (ZA) in elderly patients is a risk factor for the development of medication-related osteonecrosis of the jaws (MRONJ), mainly related to surgical triggers such as tooth extraction. However, animal models for the investigation and understanding of MRONJ pathophysiology in senescent and postmenopausal stages remains to be developed and characterized. The aim of this study was to analyze MRONJ development in senescent female mice treated with cumulative dosages of ZA. For this purpose, twenty 129/Sv female mice, 64 weeks old, were treated with 0.9% saline solution as Control group (n=10), and with ZA at 250µg/Kg (n=10), once a week, starting 4 weeks before the upper right incisor extraction and until the end of the experimental time points (7 days and 21 days). At 7 and 21 days, specimens were harvested for microCT, histological, birefringence and immunohistochemical analysis. Clinically, an incomplete epithelialization was observed in ZA group at 7 days and a delayed bone matrix mineralization and collagen maturation at 7 and 21 days compared to the controls. Controls revealed sockets filled with mature bone at 21 days as observed by microCT and birefringence, while ZA group presented delayed bone deposition at 7 and 21 days, as well increased leukocyte infiltration and blood clot at 7 days, and increased bone sequestrum and empty osteocyte lacunae at 21 days (p<0.05). Also, ZA group presented decreased quantity TGFb+ and Runx-2+ cells at 7 days, and decreased quantity of TRAP+ osteoclasts compared to the control at 21 days (p<0.05). Togheter, these data demonstrate the usefulness of this model to understanding the pathophysiology of MRONJ." @default.
- W2921718013 created "2019-03-22" @default.
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- W2921718013 date "2019-03-11" @default.
- W2921718013 modified "2023-10-01" @default.
- W2921718013 title "Medication-related osteonecrosis of the jaws after tooth extraction in senescent female mice treated with zoledronic acid: microtomographic, histological and immunohistochemical characterization" @default.
- W2921718013 cites W1523848206 @default.
- W2921718013 cites W1536865010 @default.
- W2921718013 cites W1581119831 @default.
- W2921718013 cites W1771974095 @default.
- W2921718013 cites W1881952764 @default.
- W2921718013 cites W1968089570 @default.
- W2921718013 cites W1968451395 @default.
- W2921718013 cites W1968743685 @default.
- W2921718013 cites W1970993628 @default.
- W2921718013 cites W1971271365 @default.
- W2921718013 cites W1977041638 @default.
- W2921718013 cites W1982267750 @default.
- W2921718013 cites W1985816144 @default.
- W2921718013 cites W1989061098 @default.
- W2921718013 cites W1999002615 @default.
- W2921718013 cites W1999925297 @default.
- W2921718013 cites W2000082716 @default.
- W2921718013 cites W2005319925 @default.
- W2921718013 cites W2005786706 @default.
- W2921718013 cites W2019269134 @default.
- W2921718013 cites W2019582558 @default.
- W2921718013 cites W2020238012 @default.
- W2921718013 cites W2022400490 @default.
- W2921718013 cites W2028488567 @default.
- W2921718013 cites W2029546905 @default.
- W2921718013 cites W2032829585 @default.
- W2921718013 cites W2033471620 @default.
- W2921718013 cites W2038965450 @default.
- W2921718013 cites W2052501718 @default.
- W2921718013 cites W2058889454 @default.
- W2921718013 cites W2059859647 @default.
- W2921718013 cites W2066749771 @default.
- W2921718013 cites W2076370157 @default.
- W2921718013 cites W2076804839 @default.
- W2921718013 cites W2080147361 @default.
- W2921718013 cites W2084082162 @default.
- W2921718013 cites W2093869924 @default.
- W2921718013 cites W2096022216 @default.
- W2921718013 cites W2096790979 @default.
- W2921718013 cites W2122268473 @default.
- W2921718013 cites W2131310374 @default.
- W2921718013 cites W2132701025 @default.
- W2921718013 cites W2135444604 @default.
- W2921718013 cites W2145357218 @default.
- W2921718013 cites W2157336818 @default.
- W2921718013 cites W2170309090 @default.
- W2921718013 cites W2172267987 @default.
- W2921718013 cites W2197435471 @default.
- W2921718013 cites W2293416144 @default.
- W2921718013 cites W2394566414 @default.
- W2921718013 cites W2441297198 @default.
- W2921718013 cites W2444404621 @default.
- W2921718013 cites W2486620161 @default.
- W2921718013 cites W2509370936 @default.
- W2921718013 cites W2512265399 @default.
- W2921718013 cites W2517857384 @default.
- W2921718013 cites W2518745750 @default.
- W2921718013 cites W2528126223 @default.
- W2921718013 cites W2529522429 @default.
- W2921718013 cites W2559774788 @default.
- W2921718013 cites W2585661817 @default.
- W2921718013 cites W2587989700 @default.
- W2921718013 cites W2622329949 @default.
- W2921718013 cites W2622867722 @default.
- W2921718013 cites W2741934342 @default.
- W2921718013 cites W2756265795 @default.
- W2921718013 cites W2766698915 @default.
- W2921718013 cites W2807971656 @default.
- W2921718013 cites W2884212122 @default.
- W2921718013 cites W2885811162 @default.
- W2921718013 cites W2917177127 @default.
- W2921718013 cites W408663002 @default.
- W2921718013 cites W4230399767 @default.
- W2921718013 cites W4239901602 @default.
- W2921718013 doi "https://doi.org/10.1101/574111" @default.
- W2921718013 hasPublicationYear "2019" @default.
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