FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2921718657> ?p ?o ?g. }

• W2921718657 endingPage "431" @default.
• W2921718657 startingPage "425" @default.
• W2921718657 abstract "Young adults are disproportionately affected by depression and related mental disorders. Circadian misalignment (a phase advance or delay in the body's internal clock timing) is thought to exert adverse effects on downstream physiological processes regulating mood. Circadian disruption may represent an additional, under-appreciated risk factor affecting young adults. Here, we test the hypothesis that depression in young adults is associated with circadian misalignment—the lack of concordance between an individual's endogenous rhythm and their external social and academic environment. We screened 528 individuals for morningness-eveningness diurnal preference and sleep-wake chronotype. We selected individuals with extreme scores (n = 130) for estimation of circadian phase by measuring clock gene mRNA oscillations in hair follicles (a peripheral clock). Using an independent, data-driven cluster analysis, we define the circadian misalignment of both advanced- and delayed-phase individuals from clock gene mRNA expression levels. We compare depression (BDI-II), anxiety (STAI), social jetlag, sleep duration, and sleep disturbance (PROMIS) scores between misaligned individuals and control individuals of intermediate chronotype (n = 173). We demonstrate that depression scores in young adults are significantly higher in individuals with circadian phase delays and in individuals with a mismatch between circadian behavioral phenotypes and circadian molecular phase. Evening-type individuals with circadian phase delays are 20 times more likely and mismatched individuals are 5–8 times more likely to be depressed than control individuals. Sleep disturbance shows a similar relationship with circadian phenotypes, but the mood effects described in this study are independent of sleep duration, social jetlag and gender. Our study examined peripheral clock genes that represents a circadian rhythm potentially influenced by both intrinsic and external, environmental factors. Our study population spanned a limited age-group and our results cannot distinguish between cause and effect of circadian, sleep and mood variables. Our study validates previous theoretical predictions of circadian effects on mood disorders and highlights a critical, hidden risk factor affecting mood in young adults—circadian disruption." @default.
• W2921718657 created "2019-03-22" @default.
• W2921718657 creator A5008393788 @default.
• W2921718657 creator A5009214857 @default.
• W2921718657 creator A5012058744 @default.
• W2921718657 creator A5050560160 @default.
• W2921718657 creator A5075082356 @default.
• W2921718657 date "2019-05-01" @default.
• W2921718657 modified "2023-10-01" @default.
• W2921718657 title "In vivo molecular chronotyping, circadian misalignment, and high rates of depression in young adults" @default.
• W2921718657 cites W1526523922 @default.
• W2921718657 cites W1698858557 @default.
• W2921718657 cites W1986517122 @default.
• W2921718657 cites W1993938981 @default.
• W2921718657 cites W2006352405 @default.
• W2921718657 cites W2011039340 @default.
• W2921718657 cites W2012336724 @default.
• W2921718657 cites W2013946239 @default.
• W2921718657 cites W2014273126 @default.
• W2921718657 cites W2014579124 @default.
• W2921718657 cites W2023562760 @default.
• W2921718657 cites W2037243762 @default.
• W2921718657 cites W2040388348 @default.
• W2921718657 cites W2042957122 @default.
• W2921718657 cites W2044209697 @default.
• W2921718657 cites W2049576486 @default.
• W2921718657 cites W2052890134 @default.
• W2921718657 cites W2053601856 @default.
• W2921718657 cites W2079575736 @default.
• W2921718657 cites W2103473672 @default.
• W2921718657 cites W2111970405 @default.
• W2921718657 cites W2113790044 @default.
• W2921718657 cites W2123106689 @default.
• W2921718657 cites W2147689776 @default.
• W2921718657 cites W2148645407 @default.
• W2921718657 cites W2149288592 @default.
• W2921718657 cites W2152077653 @default.
• W2921718657 cites W2157015105 @default.
• W2921718657 cites W2157781186 @default.
• W2921718657 cites W2160187477 @default.
• W2921718657 cites W2162691926 @default.
• W2921718657 cites W2162835887 @default.
• W2921718657 cites W2163145097 @default.
• W2921718657 cites W2171931117 @default.
• W2921718657 cites W2281709244 @default.
• W2921718657 cites W2285691134 @default.
• W2921718657 cites W2473948620 @default.
• W2921718657 cites W2745446500 @default.
• W2921718657 cites W2795532468 @default.
• W2921718657 doi "https://doi.org/10.1016/j.jad.2019.03.050" @default.
• W2921718657 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30878655" @default.
• W2921718657 hasPublicationYear "2019" @default.
• W2921718657 type Work @default.
• W2921718657 sameAs 2921718657 @default.
• W2921718657 citedByCount "29" @default.
• W2921718657 countsByYear W29217186572019 @default.
• W2921718657 countsByYear W29217186572020 @default.
• W2921718657 countsByYear W29217186572021 @default.
• W2921718657 countsByYear W29217186572022 @default.
• W2921718657 countsByYear W29217186572023 @default.
• W2921718657 crossrefType "journal-article" @default.
• W2921718657 hasAuthorship W2921718657A5008393788 @default.
• W2921718657 hasAuthorship W2921718657A5009214857 @default.
• W2921718657 hasAuthorship W2921718657A5012058744 @default.
• W2921718657 hasAuthorship W2921718657A5050560160 @default.
• W2921718657 hasAuthorship W2921718657A5075082356 @default.
• W2921718657 hasConcept C118552586 @default.
• W2921718657 hasConcept C121332964 @default.
• W2921718657 hasConcept C121446783 @default.
• W2921718657 hasConcept C126322002 @default.
• W2921718657 hasConcept C1276947 @default.
• W2921718657 hasConcept C134018914 @default.
• W2921718657 hasConcept C139719470 @default.
• W2921718657 hasConcept C1513209611 @default.
• W2921718657 hasConcept C15744967 @default.
• W2921718657 hasConcept C162324750 @default.
• W2921718657 hasConcept C169760540 @default.
• W2921718657 hasConcept C201176492 @default.
• W2921718657 hasConcept C2776476923 @default.
• W2921718657 hasConcept C2776867660 @default.
• W2921718657 hasConcept C2778442489 @default.
• W2921718657 hasConcept C2780733359 @default.
• W2921718657 hasConcept C2781210498 @default.
• W2921718657 hasConcept C38606739 @default.
• W2921718657 hasConcept C39282277 @default.
• W2921718657 hasConcept C42407357 @default.
• W2921718657 hasConcept C47056694 @default.
• W2921718657 hasConcept C558461103 @default.
• W2921718657 hasConcept C70410870 @default.
• W2921718657 hasConcept C71924100 @default.
• W2921718657 hasConcept C86803240 @default.
• W2921718657 hasConceptScore W2921718657C118552586 @default.
• W2921718657 hasConceptScore W2921718657C121332964 @default.
• W2921718657 hasConceptScore W2921718657C121446783 @default.
• W2921718657 hasConceptScore W2921718657C126322002 @default.
• W2921718657 hasConceptScore W2921718657C1276947 @default.
• W2921718657 hasConceptScore W2921718657C134018914 @default.
• W2921718657 hasConceptScore W2921718657C139719470 @default.

• next