FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2921729646> ?p ?o ?g. }

• W2921729646 endingPage "S1323" @default.
• W2921729646 startingPage "S1323" @default.
• W2921729646 abstract "Despite the fact that 15 - 25% of patients are colonized with Clostridium Difficile(CD) after a hospital admission or a course of antibiotics, CD bacteremia and extra-intestinal manifestations remain rare. Herein we present a unique case of a large liver abscess related to CD in an otherwise healthy individual in the absence of colitis. A 43-year-old Hispanic male with no previous medical problems presented with one week of fevers and right upper quadrant abdominal pain. The patient denies having diarrhea or recent antibiotic use. On exam, he was febrile to 39.0 Celsius, hemodynamically stable, with hepatomegaly, right upper quadrant tenderness to palpation and negative murphy's sign. Lab studies showed a white cell count of 17.3 k/mm3. A contrast CT of the abdomen showed two right lobe hepatic fluid collections measuring 10 cm (Figure 1) and 3 cm respectively. The patient was started on broad-spectrum antibiotics with Vancomycin and Piperacillin/Tazobactam but continued to deteriorate. Ultrasound guided percutaneous abscess drain placement was performed with a brown purulent material aspirated from the abscess. Gram stain showed gram-positive bacilli with pending culture results. Despite drain placement, the patient's clinical status continued to worsen. Hence, he was taken back for an image guided drain repositioning to ensure adequate drainage of the large abscess. Following the procedure, the patient became acutely hypotensive requiring escalating doses of vasopressors. Antibiotics were broadened once again to include micafungin and metronidazole. However, the patient developed multiorgan failure and expired. One week later anaerobic abscess cultures grew Clostridium Difficile. Of note that all blood cultures remained negative. Autopsy showed a hepatic fluid collection filled with dark brown measuring 11.5X10X8.5 cm and a normal colon without evidence of pseudomembranous colitis. Pyogenic hepatic abscesses are usually polymicrobial with the most common pathogens being E. coli, Klebsiella and Streptococcus.To our knowledge, this is the first case of hepatic liver abscess related to CD infection in the absence of associated CD colitis. Extracolonic CD infections are rare and difficult to diagnose and subsequently carry a poor prognosis. Unfortunately for our patient the lack of early identification of the infection due to slow growth on anaerobic cultures along with a sub-optimal abscess drainage were major contributing factors to his poor outcome.2361 Figure 1. The Computerized Tomography (CT) image of the abdomen showing a 10 cm hypodense lesion in the right lobe of the liver concerning for a Hepatic Abscess. The right lobe of the liver is the most common site of involvement because it receives a large amount of blood supply." @default.
• W2921729646 created "2019-03-22" @default.
• W2921729646 creator A5003157940 @default.
• W2921729646 creator A5074185315 @default.
• W2921729646 creator A5083020353 @default.
• W2921729646 creator A5088269779 @default.
• W2921729646 date "2018-10-01" @default.
• W2921729646 modified "2023-09-26" @default.
• W2921729646 title "Clostridium difficile: A Rare Cause of Hepatic Abscess" @default.
• W2921729646 doi "https://doi.org/10.14309/00000434-201810001-02360" @default.
• W2921729646 hasPublicationYear "2018" @default.
• W2921729646 type Work @default.
• W2921729646 sameAs 2921729646 @default.
• W2921729646 citedByCount "0" @default.
• W2921729646 crossrefType "journal-article" @default.
• W2921729646 hasAuthorship W2921729646A5003157940 @default.
• W2921729646 hasAuthorship W2921729646A5074185315 @default.
• W2921729646 hasAuthorship W2921729646A5083020353 @default.
• W2921729646 hasAuthorship W2921729646A5088269779 @default.
• W2921729646 hasConcept C141071460 @default.
• W2921729646 hasConcept C2777035434 @default.
• W2921729646 hasConcept C2777396551 @default.
• W2921729646 hasConcept C2777637488 @default.
• W2921729646 hasConcept C2778193466 @default.
• W2921729646 hasConcept C2778651397 @default.
• W2921729646 hasConcept C2778980435 @default.
• W2921729646 hasConcept C2779443120 @default.
• W2921729646 hasConcept C2779489039 @default.
• W2921729646 hasConcept C2779690883 @default.
• W2921729646 hasConcept C2780955771 @default.
• W2921729646 hasConcept C2994496256 @default.
• W2921729646 hasConcept C501593827 @default.
• W2921729646 hasConcept C523546767 @default.
• W2921729646 hasConcept C54355233 @default.
• W2921729646 hasConcept C71924100 @default.
• W2921729646 hasConcept C86803240 @default.
• W2921729646 hasConcept C89423630 @default.
• W2921729646 hasConceptScore W2921729646C141071460 @default.
• W2921729646 hasConceptScore W2921729646C2777035434 @default.
• W2921729646 hasConceptScore W2921729646C2777396551 @default.
• W2921729646 hasConceptScore W2921729646C2777637488 @default.
• W2921729646 hasConceptScore W2921729646C2778193466 @default.
• W2921729646 hasConceptScore W2921729646C2778651397 @default.
• W2921729646 hasConceptScore W2921729646C2778980435 @default.
• W2921729646 hasConceptScore W2921729646C2779443120 @default.
• W2921729646 hasConceptScore W2921729646C2779489039 @default.
• W2921729646 hasConceptScore W2921729646C2779690883 @default.
• W2921729646 hasConceptScore W2921729646C2780955771 @default.
• W2921729646 hasConceptScore W2921729646C2994496256 @default.
• W2921729646 hasConceptScore W2921729646C501593827 @default.
• W2921729646 hasConceptScore W2921729646C523546767 @default.
• W2921729646 hasConceptScore W2921729646C54355233 @default.
• W2921729646 hasConceptScore W2921729646C71924100 @default.
• W2921729646 hasConceptScore W2921729646C86803240 @default.
• W2921729646 hasConceptScore W2921729646C89423630 @default.
• W2921729646 hasIssue "Supplement" @default.
• W2921729646 hasLocation W29217296461 @default.
• W2921729646 hasOpenAccess W2921729646 @default.
• W2921729646 hasPrimaryLocation W29217296461 @default.
• W2921729646 hasRelatedWork W1966018464 @default.
• W2921729646 hasRelatedWork W2072995469 @default.
• W2921729646 hasRelatedWork W2113203807 @default.
• W2921729646 hasRelatedWork W2336241152 @default.
• W2921729646 hasRelatedWork W2410840307 @default.
• W2921729646 hasRelatedWork W2422178822 @default.
• W2921729646 hasRelatedWork W2465162801 @default.
• W2921729646 hasRelatedWork W2618744742 @default.
• W2921729646 hasRelatedWork W2753062351 @default.
• W2921729646 hasRelatedWork W4221056559 @default.
• W2921729646 hasVolume "113" @default.
• W2921729646 isParatext "false" @default.
• W2921729646 isRetracted "false" @default.
• W2921729646 magId "2921729646" @default.
• W2921729646 workType "article" @default.