FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2921731068> ?p ?o ?g. }

• W2921731068 endingPage "337" @default.
• W2921731068 startingPage "324" @default.
• W2921731068 abstract "We investigated the effect in vitro and in vivo of doxycycline hyclate (Dx), a broad-spectrum antibiotic inhibitor of matrix metaloproteinases (MMPs), on adult Schistosoma mansoni worms and granulomatous liver inflammation in infected mice. Adult S. mansoni worms in culture treated with different concentrations of Dx (50-180 μg/mL) were studied for eight days to assess its morphology, eggs production, and mortality. Uninfected mice and those infected with S. mansoni, untreated and treated with praziquantel (Pz; 200 mg/kg) or Dx (50 mg/kg), were evaluated for 60 days. Our results indicated that Dx induced dose-dependent integumentary lesions (bubbles, tubercle collapse, spicule disappearance, peeling, and erosion), reduced mating rate and eggs-laying in adult S. mansoni worms. The effective lethal dose required to kill 50% of worms was 112.0 μg/mL Dx (DL50). In mice, S. mansoni infection induced hepatomegaly, intense IL-4, IL-10, TNF-α and TGF-β production, granulomatous inflammation and hepatic glycogen depletion. The number and size of the granulomas was similar in untreated and Dx-treated animals. Untreated animals showed a predominance of productive granulomas, and intense MMP-2 and MMP-9 activities. Dx-treated mice exhibited a significant increase in IL-4 levels, tissue inflammation, proportion of involutive granulomas, and hepatic collagenogenesis, as well as attenuated MMP-2 and MMP-9 activities. Our findings indicated that Dx is toxic to adult S. mansoni worms in vitro. However, in vitro beneficial effects were not reproduced in vivo, since Dx treatment increased liver granulomatous inflammation and collagenogenesis in S. mansoni-infected mice by a process potentially associated with Dx-mediated hepatic MMP-2 and MMP-9 inhibition." @default.
• W2921731068 created "2019-03-22" @default.
• W2921731068 creator A5002092510 @default.
• W2921731068 creator A5008752634 @default.
• W2921731068 creator A5010215972 @default.
• W2921731068 creator A5018206064 @default.
• W2921731068 creator A5031133782 @default.
• W2921731068 creator A5048865011 @default.
• W2921731068 creator A5056005409 @default.
• W2921731068 creator A5086032440 @default.
• W2921731068 date "2019-05-01" @default.
• W2921731068 modified "2023-10-18" @default.
• W2921731068 title "Doxycycline hyclate: A schistosomicidal agent in vitro with immunomodulatory potential on granulomatous inflammation in vivo" @default.
• W2921731068 cites W1435064247 @default.
• W2921731068 cites W1514828574 @default.
• W2921731068 cites W1549521886 @default.
• W2921731068 cites W1583698670 @default.
• W2921731068 cites W1661510769 @default.
• W2921731068 cites W1757511072 @default.
• W2921731068 cites W1913137765 @default.
• W2921731068 cites W1958979802 @default.
• W2921731068 cites W1965235780 @default.
• W2921731068 cites W1970241249 @default.
• W2921731068 cites W1974282167 @default.
• W2921731068 cites W1974688077 @default.
• W2921731068 cites W1974706615 @default.
• W2921731068 cites W1975852458 @default.
• W2921731068 cites W1979716868 @default.
• W2921731068 cites W1981269419 @default.
• W2921731068 cites W1987475804 @default.
• W2921731068 cites W1990985580 @default.
• W2921731068 cites W2003612972 @default.
• W2921731068 cites W2007682492 @default.
• W2921731068 cites W2011587893 @default.
• W2921731068 cites W2014808039 @default.
• W2921731068 cites W2015472023 @default.
• W2921731068 cites W2016554818 @default.
• W2921731068 cites W2019621761 @default.
• W2921731068 cites W2019843033 @default.
• W2921731068 cites W2023503151 @default.
• W2921731068 cites W2024992877 @default.
• W2921731068 cites W2027956620 @default.
• W2921731068 cites W2028717651 @default.
• W2921731068 cites W2033647833 @default.
• W2921731068 cites W2037283794 @default.
• W2921731068 cites W2039472587 @default.
• W2921731068 cites W2051840067 @default.
• W2921731068 cites W2055754434 @default.
• W2921731068 cites W2060208093 @default.
• W2921731068 cites W2060866280 @default.
• W2921731068 cites W2084556222 @default.
• W2921731068 cites W2096947328 @default.
• W2921731068 cites W2102265675 @default.
• W2921731068 cites W2105002372 @default.
• W2921731068 cites W2113783287 @default.
• W2921731068 cites W2117486136 @default.
• W2921731068 cites W2117769216 @default.
• W2921731068 cites W2119963981 @default.
• W2921731068 cites W2123072297 @default.
• W2921731068 cites W2123339897 @default.
• W2921731068 cites W2123793343 @default.
• W2921731068 cites W2128485653 @default.
• W2921731068 cites W2136244824 @default.
• W2921731068 cites W2145444181 @default.
• W2921731068 cites W2149579818 @default.
• W2921731068 cites W2151609412 @default.
• W2921731068 cites W2155351009 @default.
• W2921731068 cites W2158299509 @default.
• W2921731068 cites W2162987252 @default.
• W2921731068 cites W2166453736 @default.
• W2921731068 cites W2167497811 @default.
• W2921731068 cites W2170713735 @default.
• W2921731068 cites W2234649023 @default.
• W2921731068 cites W2323627954 @default.
• W2921731068 cites W2416994386 @default.
• W2921731068 cites W2518258832 @default.
• W2921731068 cites W2592297003 @default.
• W2921731068 cites W270882991 @default.
• W2921731068 cites W2737498334 @default.
• W2921731068 cites W2754919895 @default.
• W2921731068 cites W2790563877 @default.
• W2921731068 cites W4211093028 @default.
• W2921731068 doi "https://doi.org/10.1016/j.intimp.2019.02.032" @default.
• W2921731068 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30852288" @default.
• W2921731068 hasPublicationYear "2019" @default.
• W2921731068 type Work @default.
• W2921731068 sameAs 2921731068 @default.
• W2921731068 citedByCount "10" @default.
• W2921731068 countsByYear W29217310682019 @default.
• W2921731068 countsByYear W29217310682020 @default.
• W2921731068 countsByYear W29217310682021 @default.
• W2921731068 countsByYear W29217310682022 @default.
• W2921731068 crossrefType "journal-article" @default.
• W2921731068 hasAuthorship W2921731068A5002092510 @default.
• W2921731068 hasAuthorship W2921731068A5008752634 @default.
• W2921731068 hasAuthorship W2921731068A5010215972 @default.
• W2921731068 hasAuthorship W2921731068A5018206064 @default.
• W2921731068 hasAuthorship W2921731068A5031133782 @default.

• next