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- W2921732558 abstract "Metastasis of ovarian cancer is regulated by microRNAs. This study focused on the effects of miR-30a-5p on ovarian cancer migration and invasion. Our results showed that the miR-30a-5p and mucin type O-glycan biosynthesis are closely related to ovarian cancer, and that miR-30a-5p was downregulated in ovarian cancer cells. miR-30a-5p overexpression reduced cell viability and inhibited migration and invasion in HO-8910 and HO-8910PM cells. S phase kinase-associated protein 2 (SKP2), B cell lymphoma 9 (BCL9), and NOTHC1 are direct target genes of miR-30a-5p. MTDH, SKP2, BCL9, and NOTCH1 genes were overexpressed in ovarian cancer cells, and they are direct target genes of miR-30a-5p. miR-30a-5p overexpression inhibited epithelial–mesenchymal transition (EMT) process, while upregulation of SKP2, BCL9, and NOTCH1 gene expression levels reduced the inhibition of EMT process by miR-30a-5p. miR-30a-5p was lowly expressed in ovarian cancer, and such a phenomenon is related to ovarian cancer metastasis. miR-30a-5p might inhibit the migration and invasion of ovarian cancer cells by downregulating the expression of SKP2, BCL9, and NOTCH1 genes." @default.
- W2921732558 created "2019-03-22" @default.
- W2921732558 creator A5065143293 @default.
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- W2921732558 date "2019-04-01" @default.
- W2921732558 modified "2023-10-10" @default.
- W2921732558 title "Mechanism of Low Expression of <i>miR-30a-5p</i> on Epithelial–Mesenchymal Transition and Metastasis in Ovarian Cancer" @default.
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- W2921732558 doi "https://doi.org/10.1089/dna.2018.4396" @default.
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