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- W2921783635 abstract "Purpose Restrictive chronic lung allograft dysfunction (rCLAD) is associated with decreased survival but individual prognosis remains variable. Increased numbers of colony-forming units (CFU) of mesenchymal stromal cells (MSC)—the effector cells in fibroproliferation—derived from bronchoalveolar lavage (BAL) fluid have been associated with developing bronchiolitis obliterans syndrome (BOS). However, the prognostic significance of MSC in rCLAD is unknown. Methods We analyzed 82 BAL samples collected at CLAD onset and 82 paired CLAD free samples, matched on the basis of time-post transplant. MSC were quantified as CFU count per 2 × 106 cells in BAL and analyzed as were classified as BOS. CFU counts were compared using pair-wise Wicoxon rank-sum tests . Survival analyses were performed using a restricted means model and presented as Kaplan Meier curves . Results Average mesenchymal CFU counts were higher in samples from CLAD onset vs. CLAD free controls (10.99 vs. 4.37, p Conclusion rCLAD is associated with increased BAL MSC numbers, and higher mesenchymal CFU counts at time of CLAD onset are associated with progressive lung function decline and mortality. Mesenchymal CFU represent a biomarker for active fibroproliferation, which has implications for RAS pathogenesis and progression." @default.
- W2921783635 created "2019-03-22" @default.
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- W2921783635 date "2019-04-01" @default.
- W2921783635 modified "2023-09-26" @default.
- W2921783635 title "Prognostic Significance of Mesenchymal Cell Colony Forming Units in Bronchoalveolar Lavage Fluid for Restrictive Chronic Lung Allograft Dysfunction" @default.
- W2921783635 doi "https://doi.org/10.1016/j.healun.2019.01.055" @default.
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