Matches in SemOpenAlex for { <https://semopenalex.org/work/W2921787275> ?p ?o ?g. }
Showing items 1 to 86 of
86
with 100 items per page.
- W2921787275 abstract "Asthma affects nearly 300 million people worldwide, with 250,000 associated deaths annually. An estimated 5%-10% of patients have severe asthma, while only 1%-2% presented with treatment-resistant or refractory asthma. Currently, the endotype of asthma is divided into T-helper type 2 (Th2) high and Th2-low inflammation endotypes. The Th2-high endotype is characterized by eosinophilic asthma, while the Th2-low endotype is associated with neutrophilia and a pauci-granulocytic profile. The Th2-low endotype carries a high resistance to corticosteroid and bronchodilator therapy, and these patients typically have a severe and acute-onset of symptoms. We present a 57-year-old nonsmoking female with recurrent intensive care unit (ICU) admissions for severe acute asthma exacerbations, resistant to bronchodilator and steroid treatment, requiring mechanical ventilation. Currently, the guidelines for treating neutrophil-predominant Th2-low inflammation asthma have not been established. This creates a management dilemma when encountered with such a patient in clinical practice. We aim to propose targeted treatment options for these severe and potentially fatal asthma patients, with reference to current literature." @default.
- W2921787275 created "2019-03-22" @default.
- W2921787275 creator A5036940367 @default.
- W2921787275 creator A5040334567 @default.
- W2921787275 creator A5075295187 @default.
- W2921787275 creator A5076415246 @default.
- W2921787275 creator A5082985998 @default.
- W2921787275 date "2019-03-06" @default.
- W2921787275 modified "2023-10-16" @default.
- W2921787275 title "A Case of Persistent Asthma Resistant to Available Treatment Options: Management Dilemma" @default.
- W2921787275 cites W1166300377 @default.
- W2921787275 cites W182276855 @default.
- W2921787275 cites W1881180115 @default.
- W2921787275 cites W1968723792 @default.
- W2921787275 cites W2043411156 @default.
- W2921787275 cites W2061435251 @default.
- W2921787275 cites W2098276532 @default.
- W2921787275 cites W2114770406 @default.
- W2921787275 cites W2116519763 @default.
- W2921787275 cites W2488012506 @default.
- W2921787275 cites W2519341926 @default.
- W2921787275 cites W2568001054 @default.
- W2921787275 cites W2803404900 @default.
- W2921787275 cites W2803941918 @default.
- W2921787275 cites W2888190336 @default.
- W2921787275 cites W2898586096 @default.
- W2921787275 doi "https://doi.org/10.7759/cureus.4194" @default.
- W2921787275 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6504033" @default.
- W2921787275 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31106094" @default.
- W2921787275 hasPublicationYear "2019" @default.
- W2921787275 type Work @default.
- W2921787275 sameAs 2921787275 @default.
- W2921787275 citedByCount "2" @default.
- W2921787275 countsByYear W29217872752022 @default.
- W2921787275 crossrefType "journal-article" @default.
- W2921787275 hasAuthorship W2921787275A5036940367 @default.
- W2921787275 hasAuthorship W2921787275A5040334567 @default.
- W2921787275 hasAuthorship W2921787275A5075295187 @default.
- W2921787275 hasAuthorship W2921787275A5076415246 @default.
- W2921787275 hasAuthorship W2921787275A5082985998 @default.
- W2921787275 hasBestOaLocation W29217872751 @default.
- W2921787275 hasConcept C126322002 @default.
- W2921787275 hasConcept C177713679 @default.
- W2921787275 hasConcept C187212893 @default.
- W2921787275 hasConcept C2776042228 @default.
- W2921787275 hasConcept C2776376669 @default.
- W2921787275 hasConcept C2777037409 @default.
- W2921787275 hasConcept C2777802486 @default.
- W2921787275 hasConcept C2777832160 @default.
- W2921787275 hasConcept C2781018748 @default.
- W2921787275 hasConcept C2781293274 @default.
- W2921787275 hasConcept C2909082789 @default.
- W2921787275 hasConcept C71924100 @default.
- W2921787275 hasConceptScore W2921787275C126322002 @default.
- W2921787275 hasConceptScore W2921787275C177713679 @default.
- W2921787275 hasConceptScore W2921787275C187212893 @default.
- W2921787275 hasConceptScore W2921787275C2776042228 @default.
- W2921787275 hasConceptScore W2921787275C2776376669 @default.
- W2921787275 hasConceptScore W2921787275C2777037409 @default.
- W2921787275 hasConceptScore W2921787275C2777802486 @default.
- W2921787275 hasConceptScore W2921787275C2777832160 @default.
- W2921787275 hasConceptScore W2921787275C2781018748 @default.
- W2921787275 hasConceptScore W2921787275C2781293274 @default.
- W2921787275 hasConceptScore W2921787275C2909082789 @default.
- W2921787275 hasConceptScore W2921787275C71924100 @default.
- W2921787275 hasLocation W29217872751 @default.
- W2921787275 hasLocation W29217872752 @default.
- W2921787275 hasLocation W29217872753 @default.
- W2921787275 hasLocation W29217872754 @default.
- W2921787275 hasLocation W29217872755 @default.
- W2921787275 hasOpenAccess W2921787275 @default.
- W2921787275 hasPrimaryLocation W29217872751 @default.
- W2921787275 hasRelatedWork W2002613275 @default.
- W2921787275 hasRelatedWork W2002741125 @default.
- W2921787275 hasRelatedWork W2184851178 @default.
- W2921787275 hasRelatedWork W2186478762 @default.
- W2921787275 hasRelatedWork W2287163345 @default.
- W2921787275 hasRelatedWork W2386381627 @default.
- W2921787275 hasRelatedWork W2462693500 @default.
- W2921787275 hasRelatedWork W2586663018 @default.
- W2921787275 hasRelatedWork W2921787275 @default.
- W2921787275 hasRelatedWork W4385335891 @default.
- W2921787275 isParatext "false" @default.
- W2921787275 isRetracted "false" @default.
- W2921787275 magId "2921787275" @default.
- W2921787275 workType "article" @default.