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- W2921809504 endingPage "105" @default.
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- W2921809504 abstract "With an aging population and limited treatment options, osteoporosis currently represents a significant public health challenge. Recent animal studies indicate that longevity-associated SIRT1 may serve as an attractive pharmacological target for the treatment of osteoporosis and other bone related disorders. Pre-clinical studies demonstrate that mice treated with SIRT1 agonists show protection against age-related, post-menopausal, and disuse models of osteoporosis. Conversely, SIRT1 knockout models display low bone mass phenotypes associated with increased bone resorption and decreased bone formation. This review summarizes recent animal and human experimental data showing that pharmacological activation of SIRT1 may act in a manner that current treatments do not, namely by treating the imbalance in bone remodeling that is the root cause of osteoporosis and other bone disorders." @default.
- W2921809504 created "2019-03-22" @default.
- W2921809504 creator A5015907949 @default.
- W2921809504 date "2019-05-01" @default.
- W2921809504 modified "2023-10-18" @default.
- W2921809504 title "Drugs targeting SIRT1, a new generation of therapeutics for osteoporosis and other bone related disorders?" @default.
- W2921809504 cites W1587545842 @default.
- W2921809504 cites W1606867770 @default.
- W2921809504 cites W1736016875 @default.
- W2921809504 cites W1864823360 @default.
- W2921809504 cites W1958174505 @default.
- W2921809504 cites W1965696823 @default.
- W2921809504 cites W1967967197 @default.
- W2921809504 cites W1969408132 @default.
- W2921809504 cites W1969480537 @default.
- W2921809504 cites W1975580061 @default.
- W2921809504 cites W1982863620 @default.
- W2921809504 cites W1983081137 @default.
- W2921809504 cites W1988982864 @default.
- W2921809504 cites W2006950202 @default.
- W2921809504 cites W2007928508 @default.
- W2921809504 cites W2008816560 @default.
- W2921809504 cites W2023801938 @default.
- W2921809504 cites W2025126521 @default.
- W2921809504 cites W2041295404 @default.
- W2921809504 cites W2052388012 @default.
- W2921809504 cites W2053510668 @default.
- W2921809504 cites W2060272225 @default.
- W2921809504 cites W2060760516 @default.
- W2921809504 cites W2061077538 @default.
- W2921809504 cites W2061914685 @default.
- W2921809504 cites W2074740541 @default.
- W2921809504 cites W2075793755 @default.
- W2921809504 cites W2076552336 @default.
- W2921809504 cites W2077209790 @default.
- W2921809504 cites W2080192652 @default.
- W2921809504 cites W2082431118 @default.
- W2921809504 cites W2090442368 @default.
- W2921809504 cites W2091169607 @default.
- W2921809504 cites W2093023229 @default.
- W2921809504 cites W2093252878 @default.
- W2921809504 cites W2097948853 @default.
- W2921809504 cites W2103190171 @default.
- W2921809504 cites W2112964941 @default.
- W2921809504 cites W2115554047 @default.
- W2921809504 cites W2122073743 @default.
- W2921809504 cites W2122598808 @default.
- W2921809504 cites W2125810574 @default.
- W2921809504 cites W2126873568 @default.
- W2921809504 cites W2129769202 @default.
- W2921809504 cites W2131827606 @default.
- W2921809504 cites W2131862834 @default.
- W2921809504 cites W2135387645 @default.
- W2921809504 cites W2139240811 @default.
- W2921809504 cites W2151263644 @default.
- W2921809504 cites W2158124286 @default.
- W2921809504 cites W2166266977 @default.
- W2921809504 cites W2170498202 @default.
- W2921809504 cites W2171748049 @default.
- W2921809504 cites W2174139830 @default.
- W2921809504 cites W2178752165 @default.
- W2921809504 cites W2233418025 @default.
- W2921809504 cites W2237859981 @default.
- W2921809504 cites W2286156544 @default.
- W2921809504 cites W2343193821 @default.
- W2921809504 cites W2416376029 @default.
- W2921809504 cites W2427895239 @default.
- W2921809504 cites W2515158101 @default.
- W2921809504 cites W2516495404 @default.
- W2921809504 cites W2517483114 @default.
- W2921809504 cites W2530388030 @default.
- W2921809504 cites W2540673742 @default.
- W2921809504 cites W2546015443 @default.
- W2921809504 cites W2616886507 @default.
- W2921809504 cites W2753393630 @default.
- W2921809504 cites W2757024716 @default.
- W2921809504 cites W2757874772 @default.
- W2921809504 cites W2765762940 @default.
- W2921809504 cites W2769536025 @default.
- W2921809504 cites W2772388367 @default.
- W2921809504 cites W2791758888 @default.
- W2921809504 cites W2792544397 @default.
- W2921809504 cites W2794079467 @default.
- W2921809504 cites W2795014519 @default.
- W2921809504 cites W2801525193 @default.
- W2921809504 cites W2910148367 @default.
- W2921809504 cites W2915683117 @default.
- W2921809504 doi "https://doi.org/10.1016/j.phrs.2019.03.007" @default.
- W2921809504 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30862606" @default.
- W2921809504 hasPublicationYear "2019" @default.
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