Matches in SemOpenAlex for { <https://semopenalex.org/work/W2921829638> ?p ?o ?g. }
- W2921829638 endingPage "16" @default.
- W2921829638 startingPage "1" @default.
- W2921829638 abstract "Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease characterized by the degeneration of both upper and lower motor neurons. Patients show both motor and extra-motor symptoms. A cure is not available at this time, and the disease leads to death within 3-5 years, mainly due to respiratory failure. Stem cell therapy is arising as a new promising approach for the treatment of neurodegenerative disorders. In particular, mesenchymal stem cells (MSCs) seem the most suitable type of stem cells, thanks to their demonstrated beneficial effects in different experimental models, to the easy availability, and to the lack of ethical problems. In this review, we focused on the studies involving ALS rodent models and clinical trials in order to understand the potential beneficial effects of MSC transplantation. In different ALS rodent models, the administration of MSCs induced a delay in disease progression and at least a partial recovery of the motor function. In addition, clinical trials evidenced the feasibility and safety of MSC transplantation in ALS patients, given that no major adverse events were recorded. However, only partial improvements were shown. For this reason, more studies and trials are needed to clarify the real effectiveness of MSC-based therapy in ALS." @default.
- W2921829638 created "2019-03-22" @default.
- W2921829638 creator A5009847970 @default.
- W2921829638 creator A5040381615 @default.
- W2921829638 creator A5086062480 @default.
- W2921829638 date "2019-03-10" @default.
- W2921829638 modified "2023-09-29" @default.
- W2921829638 title "Mesenchymal Stem Cells: A Potential Therapeutic Approach for Amyotrophic Lateral Sclerosis?" @default.
- W2921829638 cites W1493853215 @default.
- W2921829638 cites W1564282316 @default.
- W2921829638 cites W1601534163 @default.
- W2921829638 cites W1698980491 @default.
- W2921829638 cites W1801150000 @default.
- W2921829638 cites W1866665915 @default.
- W2921829638 cites W1903942872 @default.
- W2921829638 cites W1975614567 @default.
- W2921829638 cites W1994705335 @default.
- W2921829638 cites W1999194912 @default.
- W2921829638 cites W2003595336 @default.
- W2921829638 cites W2016879629 @default.
- W2921829638 cites W2019508044 @default.
- W2921829638 cites W2025371271 @default.
- W2921829638 cites W2026597231 @default.
- W2921829638 cites W2038825679 @default.
- W2921829638 cites W2045574035 @default.
- W2921829638 cites W2066828509 @default.
- W2921829638 cites W2068833559 @default.
- W2921829638 cites W2069351132 @default.
- W2921829638 cites W2070542281 @default.
- W2921829638 cites W2072050479 @default.
- W2921829638 cites W2074562018 @default.
- W2921829638 cites W2076900766 @default.
- W2921829638 cites W2078417042 @default.
- W2921829638 cites W2079691345 @default.
- W2921829638 cites W2080757088 @default.
- W2921829638 cites W2081394676 @default.
- W2921829638 cites W2085582924 @default.
- W2921829638 cites W2089592211 @default.
- W2921829638 cites W2090907756 @default.
- W2921829638 cites W2092346883 @default.
- W2921829638 cites W2092642018 @default.
- W2921829638 cites W2092810335 @default.
- W2921829638 cites W2106306006 @default.
- W2921829638 cites W2108728336 @default.
- W2921829638 cites W2112121037 @default.
- W2921829638 cites W2114446851 @default.
- W2921829638 cites W2120321527 @default.
- W2921829638 cites W2122265985 @default.
- W2921829638 cites W2123402756 @default.
- W2921829638 cites W2124705393 @default.
- W2921829638 cites W2128061107 @default.
- W2921829638 cites W2138475604 @default.
- W2921829638 cites W2140294607 @default.
- W2921829638 cites W2144268541 @default.
- W2921829638 cites W2145041062 @default.
- W2921829638 cites W2149751073 @default.
- W2921829638 cites W2155137515 @default.
- W2921829638 cites W2155631934 @default.
- W2921829638 cites W2156969855 @default.
- W2921829638 cites W2157811993 @default.
- W2921829638 cites W2162155473 @default.
- W2921829638 cites W2166344667 @default.
- W2921829638 cites W2173520530 @default.
- W2921829638 cites W2204571250 @default.
- W2921829638 cites W2234864836 @default.
- W2921829638 cites W2234902113 @default.
- W2921829638 cites W2250201184 @default.
- W2921829638 cites W2325660992 @default.
- W2921829638 cites W2376741234 @default.
- W2921829638 cites W2402129372 @default.
- W2921829638 cites W2411026168 @default.
- W2921829638 cites W2468114364 @default.
- W2921829638 cites W2480584347 @default.
- W2921829638 cites W2508206631 @default.
- W2921829638 cites W2520511021 @default.
- W2921829638 cites W2539567223 @default.
- W2921829638 cites W2541802021 @default.
- W2921829638 cites W2557343579 @default.
- W2921829638 cites W2581446635 @default.
- W2921829638 cites W2590630359 @default.
- W2921829638 cites W2600470683 @default.
- W2921829638 cites W2600591776 @default.
- W2921829638 cites W2607420694 @default.
- W2921829638 cites W2613737923 @default.
- W2921829638 cites W2618482665 @default.
- W2921829638 cites W2746710261 @default.
- W2921829638 cites W2747120528 @default.
- W2921829638 cites W2767913857 @default.
- W2921829638 cites W2770625956 @default.
- W2921829638 cites W2790511031 @default.
- W2921829638 cites W2803272141 @default.
- W2921829638 cites W2811495931 @default.
- W2921829638 cites W2870204682 @default.
- W2921829638 cites W2872695204 @default.
- W2921829638 cites W2883948429 @default.
- W2921829638 cites W2884205788 @default.
- W2921829638 cites W2885679472 @default.
- W2921829638 cites W2889533085 @default.