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- W2921839138 abstract "Background: Patients with psoriasis (PSO), a chronic inflammatory disease associated with dysfunctional lipoprotein profile and accelerated risk of MI, have increased burden of subclinical atherogenesis by coronary computed tomography angiography (CCTA). Large HDL particle (l-HDLp) number by NMR has been shown to associate negatively with cardiovascular (CV) events independent of traditional lipoprotein levels. We hypothesize that increase in l-HDLp would inversely associate with soft plaque volume (PV) as well as non-calcified coronary burden (NCB). Methods: Consecutive treatment naïve PSO patients (n= 92 arteries) underwent CCTA (320 detector row, Toshiba) at baseline and one-year. Soft plaque volume and non-calcified burden were assessed using a semi-automated software (QAngio, Medis). Lipoprotein profiling and cholesterol efflux capacity was done by NMR. Results: Patients were middle aged and at low CV risk by traditional risk scores (Table 1). With improvement of PSO severity at one year and no change in traditional CV risks, l-HDLp increased (5.8 ± 0.4 vs. 6.3 ± 0.5, p=0.007) concurrently with cholesterol efflux capacity (0.95 ± 0.02 vs 1.01 ± 0.02, p=0.003). PV reduced at one-year (3.7 ± 1.2 vs. 2.9 ± 1.1 mm 3 , p=0.01), as well as NCB (1.20 ± 0.06 vs. 1.07 ± 0.06 mm 2 , p<0.001). Coronary burden was inversely associated with l-HDLp beyond traditional CV risk factors (β = -0.47, p<0.001). Conclusions: Increase in l-HDLp was inversely associated with coronary plaque burden possibly through improvement in HDL function via cholesterol efflux capacity, suggesting a role for NMR lipoprotein profiling in assessment of CVD in chronic inflammatory states." @default.
- W2921839138 created "2019-03-22" @default.
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- W2921839138 date "2018-05-01" @default.
- W2921839138 modified "2023-09-26" @default.
- W2921839138 title "Abstract 549: Improvement in Large Density HDL Particle Number by NMR is Associated with Reduction in Coronary Soft Plaque Burden by Coronary Computed Tomography Angiography in Psoriasis" @default.
- W2921839138 doi "https://doi.org/10.1161/atvb.38.suppl_1.549" @default.
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