FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2921840082> ?p ?o ?g. }

• W2921840082 endingPage "57" @default.
• W2921840082 startingPage "47" @default.
• W2921840082 abstract "Osteosarcoma is one of the most pernicious primary bone tumor characterized by high malignancy and metastasis, however its pathogenesis remain largely unknown. Our previous study showed elevated expression of adrenomedullin (ADM) is correlated with prognosis and disease severity in osteosarcoma patients. In this research, we continue to study the mechanisms of ADM-induced osteosarcoma cells proliferation in vitro and in vivo osteosarcoma models. The Radioimmunoassay was used to test the correlations of ADM and vascular endothelial growth factor (VEGF) expressions in plasma of osteosarcoma patients. The MTT and flow cytometry analysis were accepted to monitor the proliferation of osteosarcoma cells, meanwhile the ADM and VEGF expression were detected by real-time PCR and western blot. Moreover, the relationship among ADM and VEGF expression was also assessed in the osteosarcoma nude mice models. In this study, a significant correlation was found between ADM and VEGF expression in the plasma of osteosarcoma patients. As important stimuli in osteosarcoma proliferation, hypoxia could stimulate ADM and VEGF expression in MG-63 cells. The expressions of ADM and VEGF increased with the duration of hypoxia, which also identify the positive correlations between the expression of ADM and VEGF. The proliferation of MG-63 cells decreased when ADM was inhibited. And the proliferation increased when adding exogenous ADM, while VEGF inhibition attenuated this effect. Furthermore, ADM reduction also inhibited VEGF, CD31 expression and tumor cells growth in osteosarcoma nude mice models. These results suggested inhibition of osteosarcoma cells proliferation might be influenced by ADM through VEGF pathway, which implied ADM-VEGF signal was a potential target for impeding the proliferation of malignant cells in osteosarcoma." @default.
• W2921840082 created "2019-03-22" @default.
• W2921840082 creator A5001787815 @default.
• W2921840082 creator A5035295203 @default.
• W2921840082 creator A5041935923 @default.
• W2921840082 creator A5050844821 @default.
• W2921840082 creator A5063868076 @default.
• W2921840082 creator A5066102428 @default.
• W2921840082 date "2019-01-01" @default.
• W2921840082 modified "2023-10-03" @default.
• W2921840082 title "Downregulation of Adrenomedullin Leads to the Inhibition of the Tumorigenesis via VEGF Pathway in Human and Nude Mice Osteosarcoma Models" @default.
• W2921840082 cites W1966227891 @default.
• W2921840082 cites W1981486151 @default.
• W2921840082 cites W1983031501 @default.
• W2921840082 cites W1992761293 @default.
• W2921840082 cites W2026531960 @default.
• W2921840082 cites W2033432515 @default.
• W2921840082 cites W2037711444 @default.
• W2921840082 cites W2046175415 @default.
• W2921840082 cites W2066738020 @default.
• W2921840082 cites W2072874660 @default.
• W2921840082 cites W2076188822 @default.
• W2921840082 cites W2077654131 @default.
• W2921840082 cites W2118325904 @default.
• W2921840082 cites W2119720472 @default.
• W2921840082 cites W2120380517 @default.
• W2921840082 cites W2161707028 @default.
• W2921840082 cites W2299430615 @default.
• W2921840082 cites W2431282426 @default.
• W2921840082 cites W2496168162 @default.
• W2921840082 cites W2583135417 @default.
• W2921840082 cites W2594944671 @default.
• W2921840082 cites W2626457261 @default.
• W2921840082 cites W2689625606 @default.
• W2921840082 cites W2727303988 @default.
• W2921840082 cites W2772338135 @default.
• W2921840082 cites W2774093742 @default.
• W2921840082 cites W2774296007 @default.
• W2921840082 cites W2775716946 @default.
• W2921840082 cites W2797565182 @default.
• W2921840082 cites W2897319943 @default.
• W2921840082 cites W811147719 @default.
• W2921840082 doi "https://doi.org/10.1016/j.arcmed.2019.03.002" @default.
• W2921840082 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30890367" @default.
• W2921840082 hasPublicationYear "2019" @default.
• W2921840082 type Work @default.
• W2921840082 sameAs 2921840082 @default.
• W2921840082 citedByCount "4" @default.
• W2921840082 countsByYear W29218400822020 @default.
• W2921840082 countsByYear W29218400822022 @default.
• W2921840082 countsByYear W29218400822023 @default.
• W2921840082 crossrefType "journal-article" @default.
• W2921840082 hasAuthorship W2921840082A5001787815 @default.
• W2921840082 hasAuthorship W2921840082A5035295203 @default.
• W2921840082 hasAuthorship W2921840082A5041935923 @default.
• W2921840082 hasAuthorship W2921840082A5050844821 @default.
• W2921840082 hasAuthorship W2921840082A5063868076 @default.
• W2921840082 hasAuthorship W2921840082A5066102428 @default.
• W2921840082 hasConcept C126322002 @default.
• W2921840082 hasConcept C134018914 @default.
• W2921840082 hasConcept C146285616 @default.
• W2921840082 hasConcept C167734588 @default.
• W2921840082 hasConcept C170493617 @default.
• W2921840082 hasConcept C2777025900 @default.
• W2921840082 hasConcept C2777152744 @default.
• W2921840082 hasConcept C2777760704 @default.
• W2921840082 hasConcept C2780394083 @default.
• W2921840082 hasConcept C502942594 @default.
• W2921840082 hasConcept C71924100 @default.
• W2921840082 hasConceptScore W2921840082C126322002 @default.
• W2921840082 hasConceptScore W2921840082C134018914 @default.
• W2921840082 hasConceptScore W2921840082C146285616 @default.
• W2921840082 hasConceptScore W2921840082C167734588 @default.
• W2921840082 hasConceptScore W2921840082C170493617 @default.
• W2921840082 hasConceptScore W2921840082C2777025900 @default.
• W2921840082 hasConceptScore W2921840082C2777152744 @default.
• W2921840082 hasConceptScore W2921840082C2777760704 @default.
• W2921840082 hasConceptScore W2921840082C2780394083 @default.
• W2921840082 hasConceptScore W2921840082C502942594 @default.
• W2921840082 hasConceptScore W2921840082C71924100 @default.
• W2921840082 hasFunder F4320321001 @default.
• W2921840082 hasFunder F4320324173 @default.
• W2921840082 hasIssue "1" @default.
• W2921840082 hasLocation W29218400821 @default.
• W2921840082 hasLocation W29218400822 @default.
• W2921840082 hasOpenAccess W2921840082 @default.
• W2921840082 hasPrimaryLocation W29218400821 @default.
• W2921840082 hasRelatedWork W2077498058 @default.
• W2921840082 hasRelatedWork W2120159810 @default.
• W2921840082 hasRelatedWork W2168254088 @default.
• W2921840082 hasRelatedWork W2212174305 @default.
• W2921840082 hasRelatedWork W2379568758 @default.
• W2921840082 hasRelatedWork W2605822193 @default.
• W2921840082 hasRelatedWork W2921840082 @default.
• W2921840082 hasRelatedWork W4224009683 @default.
• W2921840082 hasRelatedWork W4226501419 @default.
• W2921840082 hasRelatedWork W2142354593 @default.
• W2921840082 hasVolume "50" @default.

• next