FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2921860318> ?p ?o ?g. }

• W2921860318 endingPage "89" @default.
• W2921860318 startingPage "82" @default.
• W2921860318 abstract "Abstract In silico approaches are becoming increasingly important tools in toxicology. This is especially the case for the cosmetics industry, where growing numbers of regions are implementing bans on the in vivo testing of ingredients and products, resulting in an increased need to be able to generate safety data in vitro and/or in silico. ‘In silico’ data include results obtained from (quantitative) structure activity relationship ((Q)SAR) models, chemical categories, grouping, read-across and physiologically-based (pharmaco)kinetic (PB(P)K) models, and ‘big data’ analysis. There are general and more specific factors to be considered when using different in silico methods, many of which are described in the multitude of guidance documents available to support their use for regulatory purposes. There are particular challenges associated with the use of in silico approaches for cosmetic safety assessment, but with proper consideration and justification as to how they have been addressed, none should be insurmountable. Whilst in silico methods are currently predominantly used for internal rather than regulatory decision making, as confidence grows in their applicability and predictivity, this is likely to change. Many of the most commonly cited issues with the use of in silico approaches relate to the need for better documentation and justification as to why the method used was appropriate. It is also frequently stated that they should be used within a weight of evidence (WoE) approach and with all available data, rather than meeting regulatory requirements as a stand-alone method. Whilst these considerations are important, it should be remembered that they are equally applicable to data generated using in vitro and in vivo methods." @default.
• W2921860318 created "2019-03-22" @default.
• W2921860318 creator A5017796153 @default.
• W2921860318 creator A5088593926 @default.
• W2921860318 date "2019-08-01" @default.
• W2921860318 modified "2023-10-18" @default.
• W2921860318 title "Regulatory acceptance of in silico approaches for the safety assessment of cosmetic-related substances" @default.
• W2921860318 cites W1897876044 @default.
• W2921860318 cites W1978576187 @default.
• W2921860318 cites W1982175090 @default.
• W2921860318 cites W1982484840 @default.
• W2921860318 cites W2010609085 @default.
• W2921860318 cites W2033757486 @default.
• W2921860318 cites W2057993701 @default.
• W2921860318 cites W2067190353 @default.
• W2921860318 cites W2086716920 @default.
• W2921860318 cites W2117809365 @default.
• W2921860318 cites W2176596140 @default.
• W2921860318 cites W2302505212 @default.
• W2921860318 cites W2319741579 @default.
• W2921860318 cites W2322262466 @default.
• W2921860318 cites W2408293494 @default.
• W2921860318 cites W2409982462 @default.
• W2921860318 cites W2562558875 @default.
• W2921860318 cites W2563115000 @default.
• W2921860318 cites W2571241414 @default.
• W2921860318 cites W2605020949 @default.
• W2921860318 cites W2606096698 @default.
• W2921860318 cites W265312277 @default.
• W2921860318 cites W2726468862 @default.
• W2921860318 cites W2740227303 @default.
• W2921860318 cites W2740946158 @default.
• W2921860318 cites W2741088520 @default.
• W2921860318 cites W2751533746 @default.
• W2921860318 cites W2756021330 @default.
• W2921860318 cites W2761529199 @default.
• W2921860318 cites W2790898262 @default.
• W2921860318 cites W2793093451 @default.
• W2921860318 cites W2794394812 @default.
• W2921860318 cites W2799297366 @default.
• W2921860318 cites W2822962393 @default.
• W2921860318 doi "https://doi.org/10.1016/j.comtox.2019.03.003" @default.
• W2921860318 hasPublicationYear "2019" @default.
• W2921860318 type Work @default.
• W2921860318 sameAs 2921860318 @default.
• W2921860318 citedByCount "25" @default.
• W2921860318 countsByYear W29218603182020 @default.
• W2921860318 countsByYear W29218603182021 @default.
• W2921860318 countsByYear W29218603182022 @default.
• W2921860318 countsByYear W29218603182023 @default.
• W2921860318 crossrefType "journal-article" @default.
• W2921860318 hasAuthorship W2921860318A5017796153 @default.
• W2921860318 hasAuthorship W2921860318A5088593926 @default.
• W2921860318 hasBestOaLocation W29218603181 @default.
• W2921860318 hasConcept C104317684 @default.
• W2921860318 hasConcept C112930515 @default.
• W2921860318 hasConcept C127413603 @default.
• W2921860318 hasConcept C144133560 @default.
• W2921860318 hasConcept C183696295 @default.
• W2921860318 hasConcept C185592680 @default.
• W2921860318 hasConcept C2775905019 @default.
• W2921860318 hasConcept C41008148 @default.
• W2921860318 hasConcept C55493867 @default.
• W2921860318 hasConcept C70721500 @default.
• W2921860318 hasConcept C86803240 @default.
• W2921860318 hasConceptScore W2921860318C104317684 @default.
• W2921860318 hasConceptScore W2921860318C112930515 @default.
• W2921860318 hasConceptScore W2921860318C127413603 @default.
• W2921860318 hasConceptScore W2921860318C144133560 @default.
• W2921860318 hasConceptScore W2921860318C183696295 @default.
• W2921860318 hasConceptScore W2921860318C185592680 @default.
• W2921860318 hasConceptScore W2921860318C2775905019 @default.
• W2921860318 hasConceptScore W2921860318C41008148 @default.
• W2921860318 hasConceptScore W2921860318C55493867 @default.
• W2921860318 hasConceptScore W2921860318C70721500 @default.
• W2921860318 hasConceptScore W2921860318C86803240 @default.
• W2921860318 hasLocation W29218603181 @default.
• W2921860318 hasOpenAccess W2921860318 @default.
• W2921860318 hasPrimaryLocation W29218603181 @default.
• W2921860318 hasRelatedWork W2003194288 @default.
• W2921860318 hasRelatedWork W2037253982 @default.
• W2921860318 hasRelatedWork W2039597160 @default.
• W2921860318 hasRelatedWork W2072543338 @default.
• W2921860318 hasRelatedWork W2074002899 @default.
• W2921860318 hasRelatedWork W2153919606 @default.
• W2921860318 hasRelatedWork W2213189664 @default.
• W2921860318 hasRelatedWork W2513589746 @default.
• W2921860318 hasRelatedWork W2953357169 @default.
• W2921860318 hasRelatedWork W3014412917 @default.
• W2921860318 hasVolume "11" @default.
• W2921860318 isParatext "false" @default.
• W2921860318 isRetracted "false" @default.
• W2921860318 magId "2921860318" @default.
• W2921860318 workType "article" @default.