Matches in SemOpenAlex for { <https://semopenalex.org/work/W2921901423> ?p ?o ?g. }
- W2921901423 endingPage "1801486" @default.
- W2921901423 startingPage "1801486" @default.
- W2921901423 abstract "Tumor growth and metastasis are the major causes of high mortality in breast cancer. In this study, a water-responsive phospholipid-calcium-carbonate hybrid nanoparticle (PL/ACC-DOX&ICG) surface modified with a phospholipid shell is designed and covered with a shielding polymer polyethylene glycol; this development is loaded with the photosensitizer indocyanine green (ICG) and the chemotherapeutic drug doxorubicin (DOX) for near-infrared (NIR) imaging and chemophotothermal combination therapy against breast cancer. PL/ACC-DOX&ICG exhibits satisfactory stability against various aqueous environments with minimal drug leakage and can readily decompose to facilitate quick drug release into cancer cells. In vivo biodistribution studies, PL/ACC-DOX&ICG demonstrated strong tumor-homing properties. Interestingly, the in vitro cellular uptake and intratumoral penetration depth of PL/ACC-DOX&ICG are significantly enhanced under NIR laser irradiation, owing to ICG-induced hyperthermia, which not only enhances cell permeability and fluidity but also disrupts the dense tumor extracellular matrix. Compared to chemotherapy or photothermal therapy alone, chemophotothermal combination therapy synergistically induces apoptosis and death in 4T1 cells. Moreover, compared with the phosphate buffer saline group, the combined treatment suppress primary tumor growth at a rate of approximately 94.88% and decrease the number of metastatic nodules by about 93.6%. Therefore, PL/ACC-DOX&ICG may be a promising nanoplatform for breast cancer treatment." @default.
- W2921901423 created "2019-03-22" @default.
- W2921901423 creator A5023586508 @default.
- W2921901423 creator A5028563062 @default.
- W2921901423 creator A5064309030 @default.
- W2921901423 creator A5066587944 @default.
- W2921901423 creator A5066714420 @default.
- W2921901423 creator A5078881653 @default.
- W2921901423 date "2019-03-11" @default.
- W2921901423 modified "2023-10-16" @default.
- W2921901423 title "Water‐Responsive Hybrid Nanoparticles Codelivering ICG and DOX Effectively Treat Breast Cancer via Hyperthermia‐aided DOX Functionality and Drug Penetration" @default.
- W2921901423 cites W1968927007 @default.
- W2921901423 cites W1986883316 @default.
- W2921901423 cites W1986995835 @default.
- W2921901423 cites W1989327660 @default.
- W2921901423 cites W2003103971 @default.
- W2921901423 cites W2031370983 @default.
- W2921901423 cites W2042315747 @default.
- W2921901423 cites W2042769575 @default.
- W2921901423 cites W2043009832 @default.
- W2921901423 cites W2060358583 @default.
- W2921901423 cites W2073298788 @default.
- W2921901423 cites W2077715063 @default.
- W2921901423 cites W2080232352 @default.
- W2921901423 cites W2084226761 @default.
- W2921901423 cites W2121982033 @default.
- W2921901423 cites W2143779949 @default.
- W2921901423 cites W2174142555 @default.
- W2921901423 cites W2214762685 @default.
- W2921901423 cites W2285012968 @default.
- W2921901423 cites W2324855605 @default.
- W2921901423 cites W2411048445 @default.
- W2921901423 cites W2526834293 @default.
- W2921901423 cites W2560809330 @default.
- W2921901423 cites W2564841767 @default.
- W2921901423 cites W2587815555 @default.
- W2921901423 cites W2610726328 @default.
- W2921901423 cites W2619737698 @default.
- W2921901423 cites W2632851236 @default.
- W2921901423 cites W2751632089 @default.
- W2921901423 cites W2762367768 @default.
- W2921901423 cites W2770316934 @default.
- W2921901423 cites W2781628393 @default.
- W2921901423 cites W2783786550 @default.
- W2921901423 cites W2789486554 @default.
- W2921901423 cites W2789542379 @default.
- W2921901423 cites W2791457767 @default.
- W2921901423 cites W2792953143 @default.
- W2921901423 cites W2804032472 @default.
- W2921901423 cites W2890509460 @default.
- W2921901423 doi "https://doi.org/10.1002/adhm.201801486" @default.
- W2921901423 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30856296" @default.
- W2921901423 hasPublicationYear "2019" @default.
- W2921901423 type Work @default.
- W2921901423 sameAs 2921901423 @default.
- W2921901423 citedByCount "59" @default.
- W2921901423 countsByYear W29219014232020 @default.
- W2921901423 countsByYear W29219014232021 @default.
- W2921901423 countsByYear W29219014232022 @default.
- W2921901423 countsByYear W29219014232023 @default.
- W2921901423 crossrefType "journal-article" @default.
- W2921901423 hasAuthorship W2921901423A5023586508 @default.
- W2921901423 hasAuthorship W2921901423A5028563062 @default.
- W2921901423 hasAuthorship W2921901423A5064309030 @default.
- W2921901423 hasAuthorship W2921901423A5066587944 @default.
- W2921901423 hasAuthorship W2921901423A5066714420 @default.
- W2921901423 hasAuthorship W2921901423A5078881653 @default.
- W2921901423 hasConcept C121608353 @default.
- W2921901423 hasConcept C126322002 @default.
- W2921901423 hasConcept C141071460 @default.
- W2921901423 hasConcept C142724271 @default.
- W2921901423 hasConcept C150903083 @default.
- W2921901423 hasConcept C171250308 @default.
- W2921901423 hasConcept C178790620 @default.
- W2921901423 hasConcept C182606246 @default.
- W2921901423 hasConcept C185592680 @default.
- W2921901423 hasConcept C192562407 @default.
- W2921901423 hasConcept C202751555 @default.
- W2921901423 hasConcept C207001950 @default.
- W2921901423 hasConcept C2776694085 @default.
- W2921901423 hasConcept C2777807558 @default.
- W2921901423 hasConcept C2779949491 @default.
- W2921901423 hasConcept C2781065829 @default.
- W2921901423 hasConcept C2781303535 @default.
- W2921901423 hasConcept C2781323092 @default.
- W2921901423 hasConcept C502942594 @default.
- W2921901423 hasConcept C530470458 @default.
- W2921901423 hasConcept C55493867 @default.
- W2921901423 hasConcept C71924100 @default.
- W2921901423 hasConcept C86803240 @default.
- W2921901423 hasConcept C96232424 @default.
- W2921901423 hasConceptScore W2921901423C121608353 @default.
- W2921901423 hasConceptScore W2921901423C126322002 @default.
- W2921901423 hasConceptScore W2921901423C141071460 @default.
- W2921901423 hasConceptScore W2921901423C142724271 @default.
- W2921901423 hasConceptScore W2921901423C150903083 @default.
- W2921901423 hasConceptScore W2921901423C171250308 @default.
- W2921901423 hasConceptScore W2921901423C178790620 @default.