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• W2921911213 abstract "Abstract Acute lymphoblastic leukemia (ALL) is the most frequent malignancy in children. With the use of more modern, efficient treatments, 5-year survival has reached more than 90% in this population. However, this achievement comes with many secondary and long-term effects since more than 65% of the survivors experience at least one severe complication, including the metabolic syndrome and cardiovascular diseases. The main objective of the present work was to characterize the composition of HDL particles isolated from pediatric ALL survivors. HDLs from 8 metabolically healthy ALL survivors, 8 metabolically unhealthy ALL survivors and 8 age- and gender-matched controls were analyzed. The HDL fraction from the survivors contained less cholesterol than the controls. In addition, proteomic analyses revealed an enrichment of pro-thrombotic (e.g., fibrinogen) and pro-inflammatory (e.g., amyloid A) proteins in the HDLs deriving from metabolically unhealthy survivors. These results indicate an alteration in the composition of lipid and protein content of HDL from childhood ALL survivors with metabolic disorders. Although more work is needed to validate the functionality of these HDLs, the data seem relevant for survivor health given the detection of potential biomarkers related to HDL metabolism and functionality in cancer." @default.
• W2921911213 created "2019-03-22" @default.
• W2921911213 creator A5004641345 @default.
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• W2921911213 date "2019-03-12" @default.
• W2921911213 modified "2023-10-14" @default.
• W2921911213 title "Altered proteome of high-density lipoproteins from paediatric acute lymphoblastic leukemia survivors" @default.
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• W2921911213 doi "https://doi.org/10.1038/s41598-019-40906-x" @default.
• W2921911213 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6414624" @default.
• W2921911213 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30862935" @default.
• W2921911213 hasPublicationYear "2019" @default.
• W2921911213 type Work @default.
• W2921911213 sameAs 2921911213 @default.

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