Matches in SemOpenAlex for { <https://semopenalex.org/work/W2921944502> ?p ?o ?g. }
Showing items 1 to 71 of
71
with 100 items per page.
- W2921944502 abstract "Introduction: Experts of pediatric endosurgery recommend early thoracoscopic resection of congenital pulmonary airway malformations (CPAM) even in asymptomatic infants due to the risk of later infections. However, neither the rate of lower airway inflammation nor the underlying microbes and their pathogenic potential have been revealed in CPAMs yet. Using latest gene-sequencing techniques, we present the first study analyzing the pulmonary microbiome in young asymptomatic infants with CPAM. Materials and Methods: Seven asymptomatic infants (age 2-3 months) underwent thoracoscopic lobectomy for CPAM. Preoperatively, blood test was taken to rule out systemic infections. Surgical specimen was screened and graded for local inflammation by hematoxylin and eosin (HE) histology. The pulmonary microbiome and mycobiome were assessed using next-generation sequencing. Results: Preoperatively, all infants had normal white blood cell counts and normal C-reactive protein (CRP) levels. Microbial evidence was found in 4/7 patients, 3 being bacteria (Pseudomonas twice, Streptococcus sp. once) and 1 fungal species (Pneumocystis jirovecii, mostly known from immunosuppressed patients, and Preussia funiculata). Histologically, both Pseudomonas and fungi were associated with low and intermediate pulmonary inflammation, whereas Streptococcus was negative for leucocyte infiltration. Conclusion: For the first time ever this study revealed genetic evidence of pathogenic microbes in 4/7 CPAMs causing lower airway inflammation in 3/7 asymptomatic young infants. Especially pseudomonas and fungi represent considerable pathogenic potential and call for a broader, age-dependent, multicenter study of CPAMs. Such data could be important for pediatric surgeons counseling parents about the necessity and timing of thoracoscopic resections." @default.
- W2921944502 created "2019-03-22" @default.
- W2921944502 creator A5011418941 @default.
- W2921944502 creator A5029200390 @default.
- W2921944502 creator A5037132971 @default.
- W2921944502 creator A5037650415 @default.
- W2921944502 creator A5042880795 @default.
- W2921944502 creator A5057543900 @default.
- W2921944502 creator A5070515236 @default.
- W2921944502 date "2019-05-01" @default.
- W2921944502 modified "2023-10-14" @default.
- W2921944502 title "Microbial Evidence in Congenital Pulmonary Airway Malformations of Young Asymptomatic Infants" @default.
- W2921944502 cites W1998639814 @default.
- W2921944502 cites W2043308150 @default.
- W2921944502 cites W2074537420 @default.
- W2921944502 cites W2081203110 @default.
- W2921944502 cites W2121728348 @default.
- W2921944502 cites W2140212995 @default.
- W2921944502 cites W2141980700 @default.
- W2921944502 cites W2339050955 @default.
- W2921944502 cites W2345523549 @default.
- W2921944502 cites W2560603970 @default.
- W2921944502 cites W2592310943 @default.
- W2921944502 cites W2621617517 @default.
- W2921944502 cites W2745582433 @default.
- W2921944502 cites W2950210786 @default.
- W2921944502 doi "https://doi.org/10.1089/lap.2017.0456" @default.
- W2921944502 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30864881" @default.
- W2921944502 hasPublicationYear "2019" @default.
- W2921944502 type Work @default.
- W2921944502 sameAs 2921944502 @default.
- W2921944502 citedByCount "5" @default.
- W2921944502 countsByYear W29219445022021 @default.
- W2921944502 countsByYear W29219445022022 @default.
- W2921944502 countsByYear W29219445022023 @default.
- W2921944502 crossrefType "journal-article" @default.
- W2921944502 hasAuthorship W2921944502A5011418941 @default.
- W2921944502 hasAuthorship W2921944502A5029200390 @default.
- W2921944502 hasAuthorship W2921944502A5037132971 @default.
- W2921944502 hasAuthorship W2921944502A5037650415 @default.
- W2921944502 hasAuthorship W2921944502A5042880795 @default.
- W2921944502 hasAuthorship W2921944502A5057543900 @default.
- W2921944502 hasAuthorship W2921944502A5070515236 @default.
- W2921944502 hasConcept C141071460 @default.
- W2921944502 hasConcept C142724271 @default.
- W2921944502 hasConcept C2777910003 @default.
- W2921944502 hasConcept C71924100 @default.
- W2921944502 hasConceptScore W2921944502C141071460 @default.
- W2921944502 hasConceptScore W2921944502C142724271 @default.
- W2921944502 hasConceptScore W2921944502C2777910003 @default.
- W2921944502 hasConceptScore W2921944502C71924100 @default.
- W2921944502 hasIssue "5" @default.
- W2921944502 hasLocation W29219445021 @default.
- W2921944502 hasLocation W29219445022 @default.
- W2921944502 hasOpenAccess W2921944502 @default.
- W2921944502 hasPrimaryLocation W29219445021 @default.
- W2921944502 hasRelatedWork W1987215768 @default.
- W2921944502 hasRelatedWork W1995188757 @default.
- W2921944502 hasRelatedWork W2057721052 @default.
- W2921944502 hasRelatedWork W2314711404 @default.
- W2921944502 hasRelatedWork W2321500876 @default.
- W2921944502 hasRelatedWork W2423950151 @default.
- W2921944502 hasRelatedWork W2763646354 @default.
- W2921944502 hasRelatedWork W3018830891 @default.
- W2921944502 hasRelatedWork W4229900919 @default.
- W2921944502 hasRelatedWork W4283155491 @default.
- W2921944502 hasVolume "29" @default.
- W2921944502 isParatext "false" @default.
- W2921944502 isRetracted "false" @default.
- W2921944502 magId "2921944502" @default.
- W2921944502 workType "article" @default.